Search results for "Drive"
showing 10 items of 543 documents
Clinical utility of plasma-based digital next-generation sequencing in oncogene-driven non-small-cell lung cancer patients with tyrosine kinase inhib…
2019
[Objectives] Resistance to tyrosine-kinase inhibitors (TKIs) is a clinical challenge in patients with oncogene-driven non-small-cell lung cancers (NSCLC). We have analyzed the utility of next-generation sequencing (NGS) of cell-free circulating tumor DNA (ctDNA) to impact the clinical care of patients with TKI resistance.
On the structural connectivity of large-scale models of brain networks at cellular level
2021
AbstractThe brain’s structural connectivity plays a fundamental role in determining how neuron networks generate, process, and transfer information within and between brain regions. The underlying mechanisms are extremely difficult to study experimentally and, in many cases, large-scale model networks are of great help. However, the implementation of these models relies on experimental findings that are often sparse and limited. Their predicting power ultimately depends on how closely a model’s connectivity represents the real system. Here we argue that the data-driven probabilistic rules, widely used to build neuronal network models, may not be appropriate to represent the dynamics of the …
Standardized on-road tests assessing fitness-to-drive in people with cognitive impairments: A systematic review.
2020
Objective The on-road assessment is the gold standard because of its ecological validity. Yet existing instruments are heterogeneous and little is known about their psychometric properties. This study identified existing on-road assessment instruments and extracted data on psychometric properties and usability in clinical settings. Method A systematic review identified studies evaluating standardized on-road evaluation instruments adapted for people with cognitive impairment. Published articles were searched on PubMed, CINHAL, PsycINFO, Web of Science, and ScienceDirect. Study quality and the level of evidence were assessed using the COSMIN checklist. The collected data were synthetized usi…
An Interactive Framework for Offline Data-Driven Multiobjective Optimization
2020
We propose a framework for solving offline data-driven multiobjective optimization problems in an interactive manner. No new data becomes available when solving offline problems. We fit surrogate models to the data to enable optimization, which introduces uncertainty. The framework incorporates preference information from a decision maker in two aspects to direct the solution process. Firstly, the decision maker can guide the optimization by providing preferences for objectives. Secondly, the framework features a novel technique for the decision maker to also express preferences related to maximum acceptable uncertainty in the solutions as preferred ranges of uncertainty. In this way, the d…
Constructions of Agency in Accounts of Drunk Driving at the Outset of Semi-Mandatory Counseling
2015
Convicted drunk drivers, in accounts of their offenses, rarely display qualities of agency that would contribute to a favorable outcome in counseling. Instead, the discursive and rhetorical aim of the accounts is often to evade responsibility and ownership of the offending behavior. Such disclaim of personal agency can be achieved in various ways in the narration of drunk driving (DD) incidences. This study examined how five aspects of agentic presentation (reflexivity, historicity, intentionality, causal attribution, and relationality) were present in or missing from such accounts. It was found that a tentative model of (non)agentic display based on those five aspects could differentiate b…
Analysis of Kinematic Parameters and Driver Behavior at Turbo Roundabouts
2018
This study focuses on both vehicle kinematic parameters (speed and acceleration) and behavior parameters (critical interval and follow-up time) of drivers at turbo-roundabouts. Empirical evaluations of such parameters can be helpful in calibrating traffic microsimulation models or assigning behavior parameters to closed-form capacity models in turbo-roundabouts (gap-acceptance capacity models) and are also related to evaluation of vehicles pollutant emissions. The research was based on traffic process observed in the first turbo-roundabout implemented in the city of Maribor in Slovenia. In 2016 a great number of traffic samples were taken with high-frame-rate video recordings [>50 frames pe…
Availability, demand, perceived constraints and disuse of ADAS technologies in Spain: findings from a national study
2019
Advanced Driver Assistance Systems (ADAS), created for enhancing the driving experience and actively preventing road crashes, have been progressively incorporated in vehicle designing essentially during the last decade. However, the literature has shown how some of these assisting technologies are not used by drivers in tandem with their potential. The aims of this study were, first, to examine the availability and demand of ADAS technologies among Spanish drivers and, secondly, to explore the perceived constraints and discouraging reasons for avoiding the use of ADAS available in their vehicles. For this national cross-sectional study, data from 1,207 Spanish drivers were analyzed. The res…
Learning from learners: a non-standard direct approach to the teaching of writing skills in EFL in a university context
2016
Corpora have been used in English as a foreign language materials for decades, and native corpora have been present in the classroom by means of direct approaches such as Data-Driven Learning (Johns, T., and P. King 1991. 'Should you be Persuaded'- Two Samples of Data-Driven Learning Materials. In Classroom Concordancing,1-16. Birmingham University. English Language Research Journal 4.). However, the suitability of using learners' output in classroom tasks remains controversial. This paper describes a pilot study in the application of a non-standard direct approach where Spanish university students are invited to reflect on their production. In the experiment, carried out in several sessions…
Comparison of quantitative Holocene temperature reconstructions using multiple proxies from a northern boreal lake
2017
Four biotic proxies (plant macrofossils, pollen, chironomids and diatoms) are employed to quantitatively reconstruct variations in mean July air temperatures ( Tjul) at Lake Loitsana (northern Finland) during the Holocene. The aim is to evaluate the robustness and biases in these temperature reconstructions and to compare the timing of highest Tjul in the individual reconstructions. The reconstructed Tjul values are evaluated in relation to local-scale/site-specific processes associated with the Holocene lake development at Loitsana as these factors have been shown to significantly influence the fossil assemblages found in the Lake Loitsana sediments. While pollen-based temperatures follow…
Mucin induces CRISPR-Cas defense in an opportunistic pathogen
2022
It is unknown what circumstances promote particular bacterial defenses against bacterial viruses (phages). Almeida & Hoikkala et al. show that mucin, derived from mucus, greatly accelerates CRISPR-Cas defenses against phage in an opportunistic pathogen. Parasitism by bacteriophages has led to the evolution of a variety of defense mechanisms in their host bacteria. However, it is unclear what factors lead to specific defenses being deployed upon phage infection. To explore this question, we co-evolved the bacterial fish pathogen Flavobacterium columnare and its virulent phage V156 in presence and absence of a eukaryotic host signal (mucin) for sixteen weeks. The presence of mucin leads to a …