Search results for "Drugs"

Virtual lock-and-key approach: The in silico revival of Fischer model by means of molecular descriptors

2010

Abstract In the last years the application of computational methodologies in the medicinal chemistry fields has found an amazing development. All the efforts were focused on the searching of new leads featuring a close affinity on a specific biological target. Thus, different molecular modeling approaches in simulation of molecular behavior for a specific biological target were employed. In spite of the increasing reliability of computational methodologies, not always the designed lead, once synthesized and screened, are suitable for the chosen biological target. To give another chance to these compounds, this work tries to resume the old concept of Fischer lock-and-key model. The same can …

High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions

2018

Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance the dissolution of poorly water-soluble drug compounds. The stabilizers exert their action through electrostatic or steric interactions, however, the molecular requirements of stabilizing agents have not been studied extensively. Here, four structurally related amphiphilic Janus-dendrimers were synthesized and screened to determine the roles of different macromolecular domains on the stabilization of drug crystals. Physical interaction and nanomilling experiments have substantiated that Janus-dendrimers with fourth gen…

Spatio‐temporal assessment of illicit drug use at large scale : evidence from 7 years of international wastewater monitoring

2019

Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population‐normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. Design Analysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to…

Expert appraisal of criteria for assessing gaming disorder: An international Delphi study

2021

Background and aims Following the recognition of ‘internet gaming disorder’ (IGD) as a condition requiring further study by the DSM‐5, ‘gaming disorder’ (GD) was officially included as a diagnostic entity by the World Health Organization (WHO) in the eleventh revision of the International Classification of Diseases (ICD‐11). However, the proposed diagnostic criteria for gaming disorder remain the subject of debate, and there has been no systematic attempt to integrate the views of different groups of experts. To achieve a more systematic agreement on this new disorder, this study employed the Delphi expert consensus method to obtain expert agreement on the diagnostic validity, clinical util…

Responsabilità per danno da farmaco tra gestione del rischio e ruolo delle informazioni

2022

Il contributo, dopo aver analizzato le conseguenze dell’inclusione della responsabilità per i danni da prodotti farmaceutici all’interno del regime della responsabilità del produttore da prodotto difettoso ovvero del paradigma di responsabilità da attività pericolose, indaga criticamente le più recenti decisioni sulla responsabilità del produttore farmaceutico, soffermandosi sulla valenza assunta dalle informazioni. In un contesto in cui le esigenze di protezione della persona richiedono un rafforzamento della tutela del consumatore, sarebbe opportuno, anche alla luce del principio di precauzione, tenere in conto il profilo della gestione del rischio e individuare nuove prospettive di tutel…

Acyclovir Delivery Matrices Based on Poly(Ethylene Glycol)/Chitosan Semi-Interpenetrating Networks

2007

Abstract Chitosan matrix systems have been studied as potential vehicles for the prolonged release of acyclovir (ACV). The influence of chitosan concentration (from 0.83% to 1.67%) on viscoelastic properties of formulations with and without glyoxal was analyzed. For chitosan‐poly(ethylene glycol) 400 formulations loss modulus ( G ″) are greater than storage modulus ( G ′). This corresponds to the characteristic behavior of nonstructured systems. When glyoxal was added to the chitosan‐poly(ethylene glycol) 400 formulations, gelled matrix was obtained (i.e., G ′ is higher than G ″), except for the lowest chitosan concentration. ACV release rates for the both types of systems, with and without…

Preparation and characterization of lipid nanoparticles as potential carriers for ester prodrugs of flurbiprofen

2011

Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids.

2020

Abstract A procedure has been developed for the determination of third-generation synthetic cannabinoids in oral fluid samples by using a semi-automated microextraction by packed sorbent (MEPS) procedure and gas chromatography–mass spectrometry (GC–MS) determination. Five synthetic cannabinoids were employed as model compounds 5F-ADB, MMB-CHMICA, THJ-2201, CUMYL-4CN-BINACA and MDMB-CHMCZCA. The most adequate operative conditions for MEPS were evaluated giving quantitative recoveries, from 89 to 124%, in synthetic and field saliva samples spiked with 125 and 250 μg/L of the studied cannabinoids, with the exception of MDMB-CHMCZCA in field saliva samples that provided slightly lower recoverie…

Determination of organic pollutants in Anguilla anguilla by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)

2021

© 2021 The Authors.

Psychosocial maladjustment in adolescence: parental socialization, self-esteem, and substance use

2018

Abstract: This study analyzes adolescents’ vulnerability based on self-esteem and substance use, with parenting style as a protective or risk factor. The sample was composed of 1445 Spanish adolescents (59.4% females), 600 early (41.5%, from 12 to 15 years old) and 845 late (58.5%, from 16 to 17 years old) adolescents. Families were classified in one of four typologies: Indulgent, authoritative, authoritarian, and neglectful. Adolescents’ adjustment was captured through self-esteem (emotional, family, and physical) and substance use (alcohol, tobacco, cannabis, and synthetic drugs). Results showed that vulnerability was greater in late adolescence than in early adolescence. An i…