Search results for "Dry eye"
showing 10 items of 75 documents
Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral su…
2013
Carmen Galbis-Estrada,1,* Maria D Pinazo-Durán,1,* Jorge Cantú-Dibildox,2 Carla Marco-Ramírez,1 Manuel Díaz-Llópis,1,3 Javier Benítez-del-Castillo21Ophthalmic Research Unit Santiago Grisolia, Department of Surgery/Ophthalmology, Faculty of Medicine, University of Valencia, Valencia, Spain; 2Department of Ophthalmology, Hospital of Jerez, Jerez de la Frontera, Cádiz, Spain; 3University and Polytechnic Hospital La Fe, Valencia, Spain*These authors contributed equally to this workBackground: Glaucoma and dry eye disorders (DEDs) are frequent comorbidities. The antioxidant and anti-inflammatory properties of essential …
Proinflammatory Cytokine Profiling of Tears from Dry Eye Patients by Means of Antibody Microarrays
2011
In the pathogenesis of keratoconjunctivitis sicca, immune processes are thought to play an important role. However, the exact details of the pathomechanisms are still unknown. In this study, the expression patterns of proinflammatory cytokines in the tears of patients with different subtypes of dry eye were analyzed.One hundred forty-three subjects subdivided into healthy controls (CTRL, n = 38), patients with aqueous-deficient dry eye (DRYaq, n = 35), patients with changes of the lipid layer (DRYlip, n = 36), and patients with a combination of both (DRYaplip, n = 34) were examined. Expression patterns of proteins (e.g., IL-1β, IL-6, ITNF-α, and IFN-γ) were examined using an advanced antibo…
Tears as a source of biomarkers for ocular and systemic diseases
2013
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers which are correlated with a certain disease. Tear proteins have been investigated extensively in the past and distinct relations between the levels of certain tear proteins to different disorders have been demonstrated. In this review we attempt to summarize proteomic technologies for biomarker identification in tears and some disease related biomarkers in tear fluids that were discovered through different proteomic techniques in different conditions like dry eye, Sjogren's syndrome, contact lens wearers, glaucoma, diabetic retinopathy or cancer. Proteomic analysis of tear fluid has proven to be a pr…
An Emerging Method to Assess Tear Film Spread and Dynamics as Possible Tear Film Homeostasis Markers
2021
This study aims to assess the performance of an analysis method to measure in vivo the movement speed of tear film particles post-blink as a measure of tear film spreading. Ocular surface parameter...
Presbyopia and the aging eye: Existing refractive approaches and their potential impact on dry eye signs and symptoms.
2020
Every part of the human body is subject to aging, including the eye. Increased prevalence of dry eye disease with age is widely acknowledged: aging threatens ocular surface homeostasis, altering the normal functioning of the lacrimal functional unit and potentially leading to signs and symptoms of dry eye. Parallelly, two additional degenerative processes take place within the crystalline lens, leading to presbyopia and cataractogenesis. With continuously increasing life expectancies both conditions are expected to impact society further. Correction strategies for presbyopia and cataracts either directly or indirectly challenge ocular surface additionally. On one hand, contact lens presbyop…
Dažādu metožu salīdzinājums sausās acs ārstēšanā
2021
Darbs ir uzrakstīts angļu valodā uz 41 lappusēm. Tajā ir 20 attēli, 10 tabulas un 45 atsauces. Abstrakts Pētījumā tika salīdzinātas trīs dažādas Sausās Acs Sindroma (SAS) ārstēšanas metodes. Pētījuma mērķis bija atrast visefektīvāko metodi vieglas, vidēji smagas un smagas pakāpes SAS ārstēšanā. Terapija tika veikta ar trīs ārstēšanas metodēm - mākslīgajām asarām, siltajām kompresēm un Lacrystim. Pēc statistiskās analīzes tika secināts, ka Lacrystim instrumentālā metode ir visefektīvākā sausās acs sindroma ārstēšanā visās smaguma pakāpēs. Mākslīgo asaru rezultāti ir salīdzināmi ar Lacrystim rezultātiem vieglos un mērenos gadījumos. Siltās kompreses nav efektīvas, jo procedūras pacients veic …
Systemic, environmental and lifestyle risk factors for dry eye disease in a mediterranean caucasian population
2022
Abstract Objectives To assess systemic, environmental and lifestyle risk factors for dry eye disease (DED) in a Mediterranean Caucasian population. Methods A cross-sectional study was performed on 120 Caucasian participants aged between 18 and 89 years (47.0 ± 22.8 years). Medical history, information regarding environmental conditions and lifestyle, Ocular Surface Disease Index, Dry Eye Questionnaire-5, non-Invasive (Oculus Keratograph 5 M) breakup time, tear film osmolarity and ocular surface staining parameters were assessed in a single clinical session to allow DED diagnosis based on the guidelines of the Tear Film and Ocular Surface Society Dry Eye Workshop II Diagnostic Methodology Re…
A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids.
2014
Purpose We used nuclear magnetic resonance spectroscopy of hydrogen-1 nuclei (1H NMR S) to analyze the metabolic profile of reflex tears from patients with dry eye disorders. Methods We performed a prospective case-control study involving 90 participants: 55 patients diagnosed with dry eye syndrome (DESG) and 35 healthy subjects (control group, CG). From the DESG, two subgroups were formed: mild DES (n=22) and moderate DES (n=33). Participants were prescribed an oral nutraceutic supplementation containing antioxidants and essential polyunsaturated fatty acids to be taken as three capsules per day for 3 months. Reflex tears (20–30 µl) were collected from the tear meniscus of both eyes of eac…
Evaluation of the MGDRx eyebag treatment in young and older subjects with dry eye symptoms
2021
Summary Objectives This study aims to evaluate the relationship between application of the MGDRx thermal eyebag and dry eye signs and symptoms in young and older subjects and to compare the results between the two groups. Methods Thirty young, healthily volunteers between 18 and 31 years of age (23.95 ± 3.94 years) and thirty older subjects between 61 and 90 years of age (77.97 ± 8.11 years) participated in this study. Ocular surface parameters were assessed using the Oculus Keratograph 5 M, following the guidelines of the Tear Film and Ocular Surface Dry Eye Workshop II Diagnostic Methodology report. Only subjects with a positive score on at least one questionnaire and an initial Non-Invas…
Digital Device Usage Time and Ocular Symptoms during COVID-19 Pandemic
2021
Bakalaura darbs ir uzrakstīts angļu valodā uz 25 lappusēm. Tas satur 10 attēlus, 6 tabulas un 22 atsauces uz literatūras avotiem. Šī pētījuma galvenais mērķis bija novērtēt kā digitālo ierīču lietošanas izmaiņas ikdienā pirms Covid-19 pandēmijas un pandēmijas laikā Itālijā ietekmē acu nogurumu. Digitālo ierīču ietekme uz acīm tika novērtēta, apkopojot pētījuma dalībnieku atbildes uz anketas jautājumiem. Digitālo ierīču izmantošana mūsdienās ir plaši izplatīta, tās ir jāizmanto, bet ievērojot nepieciešamos piesardzības pasākumus, lai neradītu traucējumus redzes un psihiskajā sistēmās.