Search results for "Dynamic"

Reproducibility of Skin Temperature Response after Cold Stress Test Using the Game Ready System: Preliminary Study

2021

The objective of this preliminary study was to determine the reproducibility of lower limbs skin temperature after cold stress test using the Game Ready system. Skin temperature of fourteen participants was measured before and after cold stress test using the Game Ready system and it was repeated the protocol in four times: at 9:00, at 11:00, at 19:00, and at 9:00 h of the posterior day. To assess skin temperature recovery after cold stress test, a logarithmic equation for each region was calculated, and constant (β0) and slope (β1) coefficients were obtained. Intraclass correlation coefficient (ICC), standard error (SE), and within-subject coefficient of variation (CV) were determined. No …

Identical fits of nonnegative matrix/tensor factorization may correspond to different extracted event-related potentials

2010

Nonnegative Matrix / Tensor factorization (NMF/NTF) have been used in the study of EEG, and the fit (explained variation) is often used to evaluate the performance of a nonnegative decomposition algorithm. However, this parameter only reveals the information derived from the mathematical model and just exhibits the reliability of the algorithms, and the property of EEG can not be reflected. If fits of two algorithms are identical, it is necessary to examine whether the desired components extracted by them are identical too. In order to verify this doubt, we performed NMF and NTF on the same dataset of an auditory event-related potentials (ERPs), and found that the identical fits of NMF and …

Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors

2020

[Image: see text] Breast cancer (BC) is the most diffused cancer type in women and the second leading cause of death among the female population. Effective strategies to fight estrogen responsive (ER+) BC, which represents 70% of all BC cases, rely on estrogen deprivation, via the inhibition of the aromatase enzyme, or the modulation of its cognate estrogen receptor. Current clinical therapies significantly increased patient survival time. Nevertheless, the onset of resistance in metastatic BC patients undergoing prolonged treatments is becoming a current clinical challenge, urgently demanding to devise innovative strategies. In this context, here we designed, synthesized, and performed in …

Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Ac…

2019

The most frequently diagnosed cancers in women are the estrogen receptor (ER)-positive breast cancer subtypes, which are characterized by estrogen dependency for their growth. The mainstay of clinical treatment for this tumor relies on the modulation of ER action or on the suppression of estrogen biosynthesis via the administration of Selective ERα Modulators/Down-regulators (SERMs/SERDs) or aromatase inhibitors, respectively. Nevertheless, de novo and acquired resistance to these therapies frequently occurs and represents a major clinical concern for patient survival. Recently, somatic mutations affecting the hormone-binding domain of ERα (i. e. Y537S, Y537N, D538G) have been associated w…

Dynamic 4D Blood Flow Representation in the Aorta and Analysis from Cine-MRI in Patients

2007

International audience; Abstract: Natural evolution of aortic disease is characterized by a diameter increase that can result in aortic dissection or rupture. Currently the evaluation of risk of rupture or dissection is based on the size of the aorta. However, this parameter is not always relevant and it appears necessary to define new parameters. In this perspective, 3D velocity imaging acquired with ECG gated velocity-encoded cine-MRI allows the aortic blood flow study. As the acquired images are not directly usable, the present study proposes a 4D-representation Of aortic blood flow in order to optimize the visualization of the particularities of non-laminar flow within the aorta. Image …

Role of Hemodynamic Forces in Unruptured Intracranial Aneurysms: An Overview of a Complex Scenario.

2017

Background An understanding of the natural history of unruptured intracranial aneurysms (IAs) has always played a critical role in presurgical or endovascular planning, to avoid possibly fatal events. Size, shape, morphology, and location are known risk factors for rupture of an aneurysm, but morphologic parameters alone may not be sufficient to perform proper rupture risk stratification. Methods We performed a systematic PubMed search and focused on hemodynamics forces that may influence aneurysmal initiation, growth, and rupture. Results We included 223 studies describing several hemodynamic parameters related to aneurysm natural history. In these studies, different modalities of aneurysm…

Visual tasks and stance width influence the spatial magnitude and temporal dynamics of standing body sway in 6- to 12-year old children.

2017

Dynamic tuning of the director field in liquid crystal shells using block copolymers

2020

When an orientationally ordered system, like a nematic liquid crystal (LC), is confined on a self-closing spherical shell, topological constraints arise with intriguing consequences that depend critically on how the LC is aligned in the shell. We demonstrate reversible dynamic tuning of the alignment, and thereby the topology, of nematic LC shells stabilized by the nonionic amphiphilic block copolymer Pluronic F127. Deep in the nematic phase, the director (the average molecule orientation) is tangential to the interface, but upon approaching the temperature TNI of the nematic– isotropic transition, the director realigns to normal. We link this to a delicate interplay between an interfacial …

Lung density distribution in dynamic CT correlates with oxygenation during pressure-controlled ventilation of pigs with lavage-ARDS

2000

Effect of a HIIT protocol on the lower limb muscle power, ankle dorsiflexion and dynamic balance in a sedentary type 1 diabetes mellitus population: …

2020

Background Type 1 diabetes mellitus (T1DM) is commonly associated with premature loss of muscle function, ankle dorsiflexion and dynamic balance. Those impairments, usually, lead to physical functionality deterioration. High-intensity interval training is an efficient and safety methodology since it prevents hypoglycemia and not requires much time, which are the main barriers for this population to practice exercise and increase physical conditioning. We hypothesized that a 6-week HIIT program performed on a cycle ergometer would increase lower limb muscle power, ankle dorsiflexion range of motion and dynamic balance without hypoglycemic situations. Methods A total of 19 diagnosed T1DM sub…