Search results for "Dynamic"

Comparison between the directly measured achilles tendon force and the tendon force calculated from the ankle joint moment during vertical jumps.

1988

Summary The purpose of this study was to compare the relationship between the achilles tendon force and the tendon force estimated from the ankle joint moment (EATF) during vertical jump. A healthy male subject performed the following jumps on the force platform: (a) maximal vertical jump from a squat position without counter-movement; (b) maximal vertical jump from an erect standing position with a preliminary counter-movement; (c) repetitive submaximal hopping on the spot with preferred frequency. The achilles tendon force was measured directly with an implanted tendon transducer in all jumping conditions. In addition the joint moment obtained from the film and ground reaction force was u…

Ritz Solution for Transient Analysis of Variable-Stiffness Shell Structures

2020

The dynamic response of thin-walled structures is driven by mass and stiffness distribution. As such, variable-stiffness (VS) composites offer opportunities to tune structural dynamic responses. To this extent, efficient analysis tools become increasingly important for structural analysis and design purposes. In this work, an efficient and versatile Ritz method for free vibrations and linear transient analysis of VS doubly curved shell structures is presented. VS shell structures are modeled as an assembly of shell-like domains. The shell kinematics is based on the first-order shear deformation theory, and no further assumption is made on the shallowness or on the thinness of the structure.…

Patient-specific computational evaluation of stiffness distribution in ascending thoracic aortic aneurysm

2021

Quantifying local aortic stiffness properties in vivo is acknowledged as essential to assess the severity of an ascending thoracic aortic aneurysm (ATAA). Recently, the LESI (local extensional stiffness identification) methodology has been established to quantify non-invasively local stiffness properties of ATAAs using electrocardiographic-gated computed tomography (ECG-gated CT) scans. The aim of the current study was to determine the most sensitive markers of local ATAA stiffness estimation with the hypothesis that direct measures of local ATAA stiffness could better detect the high-risk patients. A cohort of 30 patients (12 BAV and 18 TAV) referred for aortic size evaluation by ECG-gated…

Dynamic Functional Connectivity in the Musical Brain

2019

Musical training causes structural and functional changes in the brain due to its sensory-motor demands. This leads to differences in how musicians perceive and process music as compared to non-musicians, thereby providing insights into brain adaptations and plasticity. Correlational studies and network analysis investigations have indicated the presence of large-scale brain networks involved in the processing of music and have highlighted differences between musicians and non-musicians. However, studies on functional connectivity in the brain during music listening tasks have thus far focused solely on static network analysis. Dynamic Functional Connectivity (DFC) studies have lately been …

NEO1 and NEO-EXT studies: Long-term safety of repeat avalglucosidase alfa dosing for 4.5 years in late-onset Pompe disease patients

2019

Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat avalglucosidase alfa dosing (5, 10, or 20 mg/kg qow) for 6 months were evaluated in NEO1 (NCT01898364) in late-onset Pompe disease patients either treatment-naive (Naive) or having received alglucosidase alfa for ≥9 months (Switch). In NEO-EXT (NCT02032524), an ongoing NEO1 extension, long-term safety and pharmacokinetics of repeat avalglucosidase alfa dosing will be monitored over 6 years. Interim safety results after 4.5 years of NEO-EXT are reported here. Mean ages at NEO1 enrollment were: Naive: 44.8 (SD:20.3, range:20-78) years and Switch: 46.7 (SD:14.1, range:21-68) years. Of the 24 NEO1 parti…

Multiphoton Absorption of Myoglobin Nitric-Oxide complex: Relaxation by D-NEMD of a Stationary State

2012

ABSTRACT: The photodissociation and geminate recombination of nitric oxide in myoglobin, under continuous illumination, is modeled computationally. The relaxation of the photon energy into the protein matrix is also considered in a single simulation scheme that mimics a complete experimental setup. The dynamic approach to non-equilibrium molecular dynamics is used, starting from a steady state, to compute its relaxation to equilibrium. Simulations are conducted for the native form of sperm whale myoglobin and for two other mutants, V68W and L29F, illustrating a fair diversity of spatial and temporal geminate recombination processes. Energy flow to the heme and immediate protein environment …

Proteins in Amorphous Saccharides: Structural and Dynamical Insights on Bioprotection

2011

We report on experimental and simulative insights on saccharide-based bioprotection, obtained through the study of proteins embedded in amorphous saccharide matrices. The data presented come from a complementary set of techniques (FTIR, MD simulations and SAXS), which provides a description of the bioprotection mechanism from the atomistic to the macroscopic level. The results concur to draw a picture in which bioprotection by saccharides can be explained in terms of a tight anchorage of the protein surface to a stiff matrix, via extended hydrogen-bond networks, whose properties are defined by all its components, and are strongly dependent on the water content. In particular, they show how …

Computational Modeling of Geminate Recombination and Energy Relaxation of Nitric Oxide in Myoglobin under Constant Illumination,

2011

Réseaux de distribution de l’énergie et sobriété énergétique des territoires, les apports d’une approche thermodynamique et métabolique des systèmes …

2017

Dans le contexte de transition énergétique et de crise environnementale actuel, les intérêts des approches territoriales et systémiques de l’énergie semblent aujourd’hui admis. Cependant et malgré les nombreuses avancées dans les domaines technologiques, en matière d’urbanisme et d’aménagement ou bien encore en termes d’approches psycho-sociales et comportementales, les courbes de consommations énergétiques peinent à s’infléchir. Fort de ce constat, nous posons l’hypothèse, sur la base d’éléments théoriques empruntés à la thermodynamique et à la biologie, du rôle potentiel que pourraient jouer les réseaux de distribution énergétique, leurs caractéristiques, leur morphologie et leur dynamiqu…

Purification of Nano-Porous Silicon for Biomedical Applications

2011

Recently, various bio-medical applications of nanoporous silicon (np-Si) have been suggested. This work investigates the biocompatibility of np-Si particles taking into account hazardous residua confined in the pores after preparation. The emphasis is on the potential application of such particles as oxygen photosensitizer for photodynamic therapy of cancer, which requires both negligible toxicity of np-Si particles in darkness and a high photo-cyto-toxic effect due to generation of singlet oxygen under illumination. Considerable amounts of water soluble toxic impurities are found to be present in the nanoporous shell of micrometer-sized np-Si particles immediately after their preparation b…