Search results for "E7"
showing 10 items of 152 documents
Stage boundaries, global stratigraphy, and the time scale: towards a simplification
2004
International audience; This paper examines four facets of stratigraphic terminology and usage considered faulty and proposes corrective measures. The four perfectible areas are: (1) The system of dual nomenclature requiring discrete terminologies for the superpositional and temporal aspects of rock units. (2) The premise that a GSSP establishes the base of a stage as being coincident with the top of the preceding stage rather than simply defining it as the boundary between stages. (3) The rejection of supplementary (auxiliary) sections that would broaden the knowledge of a GSSP and enlarge the area in which it is easily usable. (4) The current dual system of nomenclature for Precambrian an…
Problems in the identity of "Crioceras" barremense Kilian, 1895 (Ancyloceratida, Late Barremian), and their proposed resolution
2010
17 pages; The study of "Crioceras" barremense KILIAN was undertaken as a part of the revision of the Hemihoplitidae. This species was considered "classic" and has been used as the index of an Upper Barremian subzone; this usage raises a number of problems. The type specimen from Tyrol was a fragment described and illustrated by UHLIG as Crioceras sp. ind. aff. roemeri. This specimen could not be retrieved, and a topotype could not be collected. Our study revealed that there is both a biostratigraphic hiatus and important differences between conceptions of this species: (1) that ascribed UHLIG's type specimen (Upper Barremian, Tyrol), (2) KILIAN's concept of the specimen he found and named "…
Pseudoshasticrioceras bersaci nov. sp. (Ammonoidea, Gassendiceratinae), and new ammonite biohorizon for the Upper Barremian of southeastern France
2009
International audience; Research in the Feraudianus Subzone of the Sartousiana Zone of the Barremian stage led to the discovery of a new species of Pseudoshasticrioceras: P. bersaci nov. sp. Its study provides evidence concerning the developments of the latest Gassendiceratinae BERT et alii, 2006, and the relationship between the genus Pseudoshasticrioceras DELANOY, 1998, and Gassendiceras BERT et alii, 2006. In particular, this new species is derived from Pseudoshasticrioceras magnini (DELANOY, 1992) by a minor revision in the processes of ontogenesis (retardation of ornamentation - neoteny). However, the evolution towards Pseudoshasticrioceras autrani DELANOY, 1998, implies a "failure" in…
Seismites resulting from high-frequency, high-magnitude earthquakes in Latvia caused by Late Glacial glacio-isostatic uplift
2016
Abstract Geologically extremely rapid changes in altitude by glacial rebound of the Earth crust after retreat of the Scandinavian Ice Sheet at the end of the last Weichselian glaciation influenced the palaeogeography of northern Europe. The uplift of the Earth crust apparently was not gradual, but shock-wise, as the uplift was accompanied by frequent, high-magnitude earthquakes. This can be deduced from strongly deformed layers which are interpreted as seismites. Such seismites have been described from several countries around the Baltic Sea, including Sweden, Germany and Poland. Now similarly deformed layers that must also be interpreted as seismites, have been discovered also in Latvia, a…
Globacrochordiceras gen. nov. (Acrochordiceratidae, late Early Triassic) and its significance for stress-induced evolutionary jumps in ammonoid linea…
2013
<i>Globacrochordiceras transpacificum</i> gen. et sp. nov. is an ammonoid (Ammonoidea, Cephalopoda) with a shell characterized by plicate ribbing (rounded and undulating ribs strengthening on the venter without interruption), increasing involution through ontogeny, overhanging and deep umbilical wall, absence of tuberculation, subtriangular whorl section, globose adult shape with a closed umbilicus followed by an abrupt egressive coiling, and a subammonitic adult suture line. This new taxon occurs in Nevada (USA) and in Guangxi (South China). It has its typical occurrence within the <i>Neopopanoceras haugi</i> Zone of late Spathian age (Early Triassic). The plicate r…
Growth patterns, sexual dimorphism, and maturation modeled in Pachypleurosauria from Middle Triassic of central Europe (Diapsida: Sauropterygia)
2018
Bone tissue, microanatomy, and growth are studied in humeri of the pachypleurosaurs Dactylosaurus from the early Anisian of Poland and of aff. Neusticosaurus pusillus from the Lettenkeuper (early Ladinian) of southern Germany. Histology and modeled growth curves are compared to already published data of other pachypleurosaurs. Therefore, we herein established growth curves for Anarosaurus from the middle Anisian of Winterswijk (the Netherlands) and for pachypleurosaurs from the Anisian/Ladinian of the Alpine Triassic (i.e., Neusticosaurus spp. and Serpianosaurus). Humeri of Dactylosaurus, Anarosaurus, and aff. N. pusillus, all from the Germanic Basin, usually display an inner ring of (pre-)…
Induction of dormancy in hypoxic human papillomavirus-positive cancer cells
2017
Oncogenic human papillomaviruses (HPVs) are closely linked to major human malignancies, including cervical and head and neck cancers. It is widely assumed that HPV-positive cancer cells are under selection pressure to continuously express the viral E6/E7 oncogenes, that their intracellular p53 levels are reconstituted on E6/E7 repression, and that E6/E7 inhibition phenotypically results in cellular senescence. Here we show that hypoxic conditions, as are often found in subregions of cervical and head and neck cancers, enable HPV-positive cancer cells to escape from these regulatory principles: E6/E7 is efficiently repressed, yet, p53 levels do not increase. Moreover, E6/E7 repression under …
HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory
2019
ABSTRACT HPV16 infections are associated with a variety of cancers and there is compelling evidence that the transforming activity of HPV16 critically depends on the expression of the viral oncoproteins E6 and E7. Therapeutic cancer vaccines capable of generating durable and specific immunity against these HPV16 antigens hold great promise to achieve long-term disease control. Here we show in mice that HPV16 E7 RNA-LPX, an intravenously administered cancer vaccine based on immuno-pharmacologically optimized antigen-encoding mRNA, efficiently primes and expands antigen-specific effector and memory CD8+ T cells. HPV-positive TC-1 and C3 tumors of immunized mice are heavily infiltrated with ac…
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
2016
The adhesion molecule CD99 is essential for the transendothelial migration of leukocytes. In this study, we used biochemical and cellular assays to show that CD99 undergoes ectodomain shedding by the metalloprotease meprin β and subsequent intramembrane proteolysis by γ-secretase. The cleavage site in CD99 was identified by mass spectrometry within an acidic region highly conserved through different vertebrate species. This finding fits perfectly to the unique cleavage specificity of meprin β with a strong preference for aspartate residues and suggests coevolution of protease and substrate. We hypothesized that limited CD99 cleavage by meprin β would alter cellular transendothelial migratio…
El género Hamatolenus Hupé, 1953 (Cámbrico Inferior-Medio) en Murero y áreas adyacentes de las CadenaS Ibéricas (NE de España)
2021
Hasta la fecha, se han definido tres subgeneros de Hamatolenus Hupe, 1953: H . ( Hamatolenus ) Hupe, 1953, H . ( Myopsolenus ) Hupe, 1953 y H . ( Lotzeia ) Sdzuy, 1958. En Espana se conocian solo representantes de los dos primeros con las especies H . ( Hamatolenus ) ibericus Sdzuy, 1958 y H . ( L .) lotzei Sdzuy, 1958. Se presenta aqui el primer ejemplar de Hamatolenus ( Myopsolenus ) encontrado en la Peninsula Iberica. El analisis de la distribucion estratigrafica del genero Hamatolenus muestra su potencial para la correlacion de las materiales situados entorno al limite Cambrico Inferior y Medio, para las facies siliciclasticas en el ambito perigondwanico. Ademas, desde un punto de vista…