Search results for "ECK"
showing 10 items of 2091 documents
Contextuality-by-Default 2.0: Systems with Binary Random Variables
2017
The paper outlines a new development in the Contextuality-by-Default theory as applied to finite systems of binary random variables. The logic and principles of the original theory remain unchanged, but the definition of contextuality of a system of random variables is now based on multimaximal rather than maximal couplings of the variables that measure the same property in different contexts: a system is considered noncontextual if these multimaximal couplings are compatible with the distributions of the random variables sharing contexts. A multimaximal coupling is one that is a maximal coupling of any subset (equivalently, of any pair) of the random variables being coupled. Arguments are …
The effect of pre-anaesthetic assessment clinic: a systematic review of randomised and non-randomised prospective controlled studies
2021
ABSTRACTObjectivesThe aim of this systematic review was to examine the effectiveness of pre-anaesthetic assessment clinics (PACs) implemented to improve quality and patient safety in perioperative care.DesignSystematic review.Data sourcesThe electronic databases CINAHL Plus with Full Text (EBSCOhost), Medline, and Embase (OvidSP) were systematically searched from 1st April, 1996 to 4th February, 2021.Eligibility criteriaThe main inclusion criterion was that the study, using empirical quantitative methods, addressed the effectiveness of PACs.Data extraction and synthesisTitles, abstracts, and full texts were screened in duplicate by two authors. Risk of bias assessment, using the Joanna Brig…
Association of Nursing Practice Environment on reported adverse events in private management hospitals: A cross‐sectional study
2021
Aims and objectives To examine the relationships between nurses' perceptions of their practice environment, other working conditions and reported adverse events in two private management hospitals. Background Patient safety is influenced by knowledge, available resources and the context in which nursing care is provided. In this sense, it has been found that certain work environments (e.g., workload, nurse turnover level, patient-to-nurse ratio, nurse staffing, nurse manager ability) influence patient outcomes. The association between nursing practice environment and reported adverse events has not been explored in private management hospitals. Design A cross-sectional study. The STROBE was…
From Herder to Strecker: Birth and Developments of the Anthropological Notion of Culture in Germany
2023
Austrian and German anthropological traditions are considered in view of the influence they had on global anthropology. The chapter is built around the centrality of the anthropological notion of culture and cultural dynamics. The particularistic and relativist notion of culture is in fact believed to have emerged from Germany from the eighteenth century, where intellectuals have juxtaposed the term Kultur to Zivilisation. Within German anthropology, universalistic perspectives on culture have continued through the nineteenth century, as in the evolutionary approach of Gustav Klemm and Johann Jakob Bachofen. A different form of cultural universalism was introduced by Adolf Bastian with his …
Test system for trifunctional antibodies in 3D MCTS culture.
2009
The aim of the present study was to assess the feasibility of a 3D tumor cell culture model, that is, multicellular tumor spheroids (MCTSs) as an adequate model for micrometastases and therefore as a pharmacological model for efficacy testing of trifunctional therapeutic antibodies. Unlike conventional monolayer cultures, spheroids allow researchers to study parameters, such as 3D cell shape, 3D cell arrangement and microenvironment, and penetration efficiency of defense cells that may largely influence the efficacy of antibody treatment in vivo. The authors established a long-term coculture of human MCTSs with peripheral blood mononuclear cells (PBMCs) to test the anticancer effect of the …
Influence of the Pecking Motion Frequency on the Cyclic Fatigue Resistance of Endodontic Rotary Files
2019
This article belongs to the Special Issue Innovations in Endodontic Dentistry.
Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells
2015
Miltirone (1) is a diterpene quinone extracted from a well-known Chinese traditional herb (Salvia miltiorrhiza). We investigated the cytotoxic effects of miltirone toward sensitive and multidrug-resistant acute lymphoblastic leukemia cell lines. Miltirone inhibited multidrug-resistant P-glycoprotein (P-gp)-overexpressing CEM/ADR5000 cells better than drug-sensitive CCRF-CEM wild-type cells, a phenomenon termed collateral sensitivity. Flow cytometric analyses revealed that miltirone induced G2/M arrest and apoptosis. Furthermore, miltirone stimulated reactive oxygen species (ROS) generation and mitochondrial membrane potential (MMP) disruption, which in turn induced DNA damage and activation…
Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin.
2022
Background: Induced senescence could be exploited to selectively counteract the proliferation of cancer cells and target them for senolysis. We examined the cellular senescence induced by curcumin and whether it could be targeted by fisetin and quercetin, flavonoids with senolytic activity. Methods: Cell-cycle profiles, chromosome number and structure, and heterochromatin markers were evaluated via flow cytometry, metaphase spreads, and immunofluorescence, respectively. The activation of p21waf1/cip1 was assessed via RT-qPCR and immunoblotting. Senescent cells were detected via SA-β-Galactosidase staining. Results: We report that curcumin treatment specifically triggers senescence in cancer…
Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence
2020
AbstractTranscriptional regulation of DNA repair is of outmost importance for the restoration of DNA integrity upon genotoxic stress. Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch repair (MMR) genes (MSH2, MSH6, EXO1) and of RAD51, the central homologous recombination repair (HR) component, ultimately leading to downregulation of MMR and HR. B[a]P-induced gene repression is caused by abrogated E2F1 signalling. This occurs through proteasomal degradation of E2F1 in G2-arrested cells and downregulation of E2F1 mRNA expression in G1-arrested cells. Repression of E2F1-me…
The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models
2014
AbstractIn spite of the novel strategies to treat colon cancer, mortality rates associated with this disease remain consistently high. Tumour recurrence has been linked to the induction of resistance towards chemotherapy that involves cellular events that enable cancer cells to escape cell death. Treatment of colon cancer mainly implicates direct or indirect DNA-damaging agents and increased repair or tolerances towards subsequent lesions contribute to generate resistant populations. Resveratrol (RSV), a potent chemosensitising polyphenol, might share common properties with chemotherapeutic drugs through its indirect DNA-damaging effects reported in vitro. In this study, we investigated how…