Search results for "ECL"

AB0458 A PHASE II RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PROOF OF CONCEPT STUDY OF ORAL SELETALISIB IN PATIENTS WITH PRIMARY SJÖGREN’S SYNDROM…

2019

Background: Seletalisib is a potent, selective oral inhibitor of phosphoinositide-3 kinase delta (PI3Kδ). Preclinical data have shown that the PI3Kδ pathway is upregulated within salivary glands of patients with PSS and contributes to disease pathogenesis.1 Objectives: To assess the efficacy and safety of seletalisib in patients with PSS. Methods: In this Phase II, double-blind, proof of concept study (NCT02610543), patients with PSS having an EULAR Sjogren’s Syndrome Disease Activity Index (ESSDAI) score ≥5 were randomised 1:1 to seletalisib once daily or placebo (PBO) in addition to current PSS therapy for 12 weeks. The primary endpoint was change from baseline in ESSDAI at Week 12. The s…

Stimulation of the ADRB3 Adrenergic Receptor Induces Relaxation of Human Placental Arteries: Influence of Preeclampsia1

2006

Preeclampsia, which complicates 3-8% of pregnancies, is one of the leading causes of neonatal morbidity and mortality. Its pathophysiology remains unclear. The aim of the present study was to investigate the presence and the role of beta2- and beta2-adrenergic receptors (ADRB2 and ADRB3, respectively) in human placental arteries and to assess the influence of preeclampsia on ADRB responsiveness. SR 59119A, salbutamol, and isoproterenol (ADRB3, ADRB2, and nonselective ADRB agonists, respectively) induced a concentration-dependent relaxation of placental artery rings obtained from women with uncomplicated or preeclamptic pregnancies. SR 59119A-induced relaxation was unaffected by the blockade…

Gated Housing Estates in the Arab World: Case Studies in Lebanon and Riyadh, Saudi Arabia

2002

The authors analyze the cultural, economic, and political background of new gated housing estates in the Arab world with the aid of case studies in Lebanon and Riyadh. Their question is to what extent these developments represent a reappearance of the fragmented settlement patterns in many of the old towns. On the one hand, new compounds of several villas and common facilities housing extended families in Riyadh may be interpreted as a revival of certain sociospatial settings in the old town, in which extended families often shared a common courtyard. The compounds for Western foreigners in Saudi Arabia follow the principle of spatial seclusion of social groups with different cultural and r…

Quia non ascendit suma : la riqueza del clero de la ciudad de Zaragoza durante la Baja Edad Media (1272-1456)

2021

[ES] El objetivo de este artículo es estudiar la riqueza y la desigualdad socioeconómica del clero zaragozano a través de las fuentes fiscales durante la Baja Edad Media. Mediante el análisis de los libros de décimas pontificias conservados en el Archivo de la Corona de Aragón y en el Archivo Apostólico Vaticano es posible documentar la tasa contributiva de los clérigos aragoneses, en general, y de los zaragozanos, en particular. En concreto, a través de un estudio cronológico amplio, se puede definir la estructura y la jerarquía de la Iglesia zaragozana, comprobar cómo evolucionó la riqueza de los eclesiásticos y cómo afectaron a este grupo heterogéneo las diferentes coyunturas económicas …

Development and Preliminary Validation of a Sport-Specific Self-Report Measure of Identity Foreclosure

2021

A sport-specific, self-report measure of identity foreclosure was developed through a systematic process that included item pool generation, expert review, administration of items to a development sample of intercollegiate student athletes (N = 326), item evaluation, and administration of scales to validation samples of intercollegiate student athletes (N = 322, N = 54, and N = 64, respectively). The process yielded two four-item scales reflecting commitment to the occupational identity of athlete and one 4-item scale reflecting active exploration of roles other than that of athlete that (a) are internally consistent and temporally stable, (b) demonstrate preliminary factorial and convergen…

Reclaimed asphalt binders and mortars fatigue behaviour

2017

Fatigue cracking is one of the most important failure mechanisms occurring in asphalt pavements, especially when mixtures incorporate considerable amount of rReclaimed asphalt pavement (RAP). In fact, aged binders contained in RAP generally make asphalt more brittle and specifically reduce fatigue resistance of the resulting asphalt mixtures. Binders and mortars play a key role in this phenomenon, considering fatigue cracking usually starts within these asphalt components. However, performance-related tests and specifications commonly regard binders and there are no sound methodologies allowing the use of mortars to predicting fatigue performance of asphalts containing RAP. For this reason,…

A practical approach to estimate the degree of binder activity of reclaimed asphalt materials

2019

Using Reclaimed Asphalt (RA) in new asphalt mixtures can reduce the amount of new material required thereby saving money and natural resources. In addition, asphalt mixtures with RA have shown comparable properties and performance to that generally associated with asphalt mixtures made with 100% virgin material. However, RA content in pavement surface layers is still limited due to specification and technical limitations. For higher contents, the aged RA binder must be analysed to accurately determine the requirements for virgin binders and additives while the degree of blending (DOB) between the RA binder and the virgin binder also needs to be quantified. This is not a simple process and g…

Differences in Participation and Performance Trends in Age Group Half and Full Marathoners

2014

International audience; Recent studies investigated participation and performance trends in age group half marathoners and full marathoners for a single event. The present study investigated participation and performance trends in age group athletes in all half marathons and full marathons held in a single country during a given period of time. Changes in running performance and age of 226,754 half marathoners and 86,419 full marathoners competing in Switzerland between 2000 and 2010 were analyzed using linear regression analyses. The number of half marathoners increased (P < 0.01) from 2000 to 2010 for both men (+231%) and women (+299%). In contrast, the number of male and female full mara…

Trabajadores migrantes en la logística holandesa. El papel de reclutadoras y agencias de trabajo temporal en la producción de vulnerabilidad

2021

BREVI OSSERVAZIONI SULL’ONERE DI SPECIFICA CONTESTAZIONE E IL DIVIETO DI NOVA IN APPELLO NEL RITO DEL LAVORO: LA CORRELAZIONE TRA ONERE DI CONTESTAZI…

2015

Oggetto dell'indagine è la non contestazione nel processo del lavoro e nel processo in generale, nell'ambito delle possibili difese della parte. La sentenza della Suprema Corte 28 febbraio 2014, n. 4854, che si colloca nel solco di un diffuso orientamento giurisprudenziale in materia di c.d. rito del lavoro, offre lo spunto per una riflessione di ordine generale sui limiti della specifica contestazione e delle conseguenze della sua omissione, nel generale sistema di preclusioni del processo civile. Essa offre, inoltre, l’occasione per una ricollocazione in chiave sistematica della non contestazione nell’ambito delle c.d. eccezioni, e nella sistematica del diritto processuale.