Search results for "ECL"
showing 10 items of 1262 documents
Association between osteocalcin and cognitive performance in healthy older adults.
2016
INTRODUCTION: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.METHODS: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor …
Metformin Use and Cognitive Function in Older Adults With Type 2 Diabetes Following a Mediterranean Diet Intervention
2021
Background and Purpose: Both adherence to the Mediterranean diet (MedDiet) and the use of metformin could benefit the cognitive performance of individuals with type 2 diabetes, but evidence is still controversial. We examined the association between metformin use and cognition in older adults with type 2 diabetes following a MedDiet intervention. Methods: Prospective cohort study framed in the PREDIMED-Plus-Cognition sub-study. The PREDIMED-Plus clinical trial aims to compare the cardiovascular effect of two MedDiet interventions, with and without energy restriction, in individuals with overweight/obesity and metabolic syndrome. The present sub-study included 487 cognitively normal subjects…
Concorsi pubblici e progressioni di carriera nella stagione del "grande reclutamento"
2022
il saggio affronta i principali problemi del sistema dei concorsi pubblici e della disciplina delle progressioni di carriera nel pubblico impiego privatizzato, alla luce delle innovazioni contenute nel d.l. 80/2021 e nella della sottoscrizione del nuovo CCNL per il comparto Funzioni Centrali.
Limits on point-like sources of ultra-high-energy neutrinos with the Pierre Auger Observatory
2019
With the Surface Detector array (SD) of the Pierre Auger Observatory we can detect neutrinos with energy between 1017 eV and 1020 eV from point-like sources across the sky, from close to the Southern Celestial Pole up to 60 in declination, with peak sensitivities at declinations around ∼-53 and ∼+55, and an unmatched sensitivity for arrival directions in the Northern hemisphere. A search has been performed for highly-inclined air showers induced by neutrinos of all flavours with no candidate events found in data taken between 1 Jan 2004 and 31 Aug 2018. Upper limits on the neutrino flux from point-like steady sources have been derived as a function of source declination. An unrivaled sensit…
Profili di costituzionalità del reclamo e della mediazione tributaria
2012
Il lavoro tratta dei profili di costituzionalità degli istituti della mediazione tributaria e del reclamo, di recente introduzione. Vengono, in particolare, esaminate le problematiche relative all'“assenza” nel procedimento di un soggetto terzo “imparziale”, della giurisdizione condizionata, del regime delle spese, della tutela cautelare, della indisponibilità della pretesa fiscale.
Factores de riesgo en el reflotamiento de pequeñas empresas
2021
Las Pymes, pequeñas y medianas empresas, constituyen una pieza importante del entramado empresarial europeo, originan la mayor parte del PIB y son responsables de crear la mayoría de puestos de trabajo. Sin embargo, son un tipo de empresas especialmente frágiles cuando sufren un declive. Por este motivo, el diagnóstico temprano y la implementación de las medidas adecuadas son clave para devolverle a la Pyme la salud empresarial de la que antes gozaba. Dada la situación débil de las Pymes y las dificultades que atraviesan cuando se enfrentan a un reflote empresarial, esta tesis doctoral tiene como objetivo identificar los factores de riesgo en el reflotamiento o turnaround de este tipo de em…
Modelos in vitro personalizados basados en células pluripotentes para el estudio de la toxicidad hepática inducida por fármacos de carácter idiosincr…
2023
El daño hepático inducido por fármacos (DILI) es una reacción adversa a medicamentos y otros xenobióticos que representa una de las causas más relevantes de fallo hepático agudo y es uno de los principales motivos de retirada de fármacos en las fases de desarrollo y farmacovigilancia. El DILI es un proceso patológico multifactorial que no se puede recapitular en los modelos in vitro actuales. Además, el DILI idiosincrático (iDILI), que es aquel que aparece en un reducido número de pacientes susceptibles, es difícil de diagnosticar y predecir en los modelos propuestos hasta el momento. Por esta razón, se han propuesto nuevos modelos capaces de reproducir las características específicas de pa…
La dynastie Beurdeley (1818-1895) : entre boutique et atelier. Une histoire du commerce des curiosités et de la création d’objets d’art au XIXe siècle
2019
The Beurdeley dynasty was established in Paris from 1818 to 1895. They were active in the trade of "curiosities" (as antiques were then described) but they also founded a workshop for the manufacture of furniture and gilt bronzes. The study of their business reveals the increasing value devoted to curiosities, the consumption and the circulation of works of art, both antique and modern, the trade and the workshop practices throughout the nineteenth century. The dual activity of dealer and manufacturer is significant and exposes the correlations between the commerce, the development of the taste for old objects following the intense circulation of merchandises triggered by the Revolution, an…
Jaunas dabas takas izveide Veclaicenē
2016
Autore sava diplomdarba izstrādei ir izvēlējusies tēmu par jaunas dabas takas izveidi Veclaicenes novadā, kuras maršruts aptvertu divu valstu teritoriju- Latvijas un Igaunijas, un šī dabas taka būtu saistoša abu valstu iedzīvotājiem. Darba mērķis ir apkopot un izanalizēt pieejamo informāciju par šādas dabas takas izveidi, kā arī, izstrādāt ieteikumus šādas takas izveidei un piemērotas vietas izvēle, balstoties uz apkopotajiem datiem. Darba gaitā autore ar aptaujas anketas palīdzību, centās uzzināt arī iedzīvotāju intereses brīvā laika pavadīšanu un attieksmi pret dabas takām, kā arī ieinteresētību doties uz Veclaiceni šādas dabas takas apmeklēšanai. Dipolmdarba izstrādes gaitā, autore ir no…
A propósito de la localización de una pintura sobre tabla de ?La Virgen de la Leche?, del siglo XIV, atribuida a Bernabé de Módena, que perteneció al…
2020
The castle's Hermitage of Yecla (Region of Murcia) constituted during the 13th to 16th centuries the first parish of the population, hosting a triptych-shaped altarpiece presided over by a tempera painting on wood of Our Lady of Humility or "Virgo Lactans", dated around 1370 and attributed to the painter Barnaba da Modena, which was the titular image of the mentioned temple under the title of Our Lady of the Incarnation, until at the end of the 18th century it changed ownership for the Conception of Our Lady. The table at averages of the eight hundred was placed in an a loft, appropriating it at the beginning of the 20th century by the retired military Pascual Spuche y Lacy, who sold it aro…