Search results for "ECL"
showing 10 items of 1262 documents
Por el Cabildo de la Santa Metropolitana Iglesia de la ciudad de Valencia sobre no aver dado la possession que pedia el dotor Benito Pichòn ... de l…
1710
Caplletra ornada Text a 1 col. - Reclams Sign.: A-Q2
Por el Procurador Fiscal de su Magestad, y Mathias Navarro clerigo, con Don Marcos Antonio Barutel, canonigo y chantre de la Catedral de Huesca / [Pe…
1650
Caplletra ornada Text a 1 col. - Reclams Sign.: A-E2
Por el Cabildo de la Santa Metropolitana Iglesia de la ciudad de Valencia sobre no aver dado la possession que pedia el dotor Benito Pichòn ... de la…
Precedeix al tít.: [Creu de Malta Existeixen exemplars de la mateixa obra amb igual tít. i paginació però amb variacions en la lletra i disposició del text Caplletra ornada Text a 1 col. - Reclams Sign.: A-Q2
Alegacion juridica por el Licenciado Francisco de Castro, Presbitero, en la causa beneficial que sigue contra Mariana Inglès, y Vicente Marcilla, Cle…
A la part superior de la port.: "J. M. J." Signada al final per D. Joaquín Ortí y Figuerola Caplletra ornada al començament del text Grav. xil. enmarcat a la port. de "S. Antonio de Padua" Sign.: [A]2, B-D2 Port. orlada Text amb postil·les marginals Reclams
Addiccion al memorial que se escriviò por el rector, clero y benef.dos. de la iglesia parroquial de San Bartholomè en esta ciudad en el pleito que en…
Signat a la fi per Pasqual Yañes Caplletra ornada Text a 1 col. - Postil·les. - Reclams Sign.: A-C2
Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis
2018
Abstract: Chemotherapy is currently the only effective approach to treat all forms of leishmaniasis. However, its effectiveness is severely limited due to high toxicity, long treatment length, drug resistance, or inadequate mode of administration. As a consequence, there is a need to identify new molecular scaffolds and targets as potential therapeutics for the treatment of this disease. We report a small series of 1,2‐substituted‐1H‐benzo[d]imidazole derivatives (9ad) showing affinity in the submicromolar range (Ki = 0.150.69 μM) toward Leishmania mexicanaCPB2.8ΔCTE, one of the more promising targets for antileishmanial drug design. The compounds confirmed activity in vitro against intrace…
Evaluación del efecto rejuvenecedor de bio-materiales sobre ligantes para mezclas con alto contenido de asfalto recuperado
2017
The interest in using bio-materials in pavement engineering has grown significantly over the last decades due to environmental concerns about the use of non-recoverable natural resources. In this paper, bio-materials are used together with Reclaimed Asphalt (RA) to restore some of the properties of the aged bitumen present in mixtures with high RA content. For this purpose, two bio-materials are studied and compared to conventional and polymer modified bitumens. Blends of these materials with RA bitumen were produced and studied to simulate a 50% RA mixture. The rejuvenating effect of the two bio-materials on RA has been assessed and compared with the effect of the conventional binders. App…
Neodymium-140 DOTA-LM3: Evaluation of an In Vivo Generator for PET with a Non-Internalizing Vector
2017
140Nd (t1/2 = 3.4 days), owing to its short-lived positron emitting daughter 140Pr (t1/2 = 3.4 min), has promise as an in vivo generator for positron emission tomography (PET). However, the electron capture decay of 140Nd is chemically disruptive to macrocycle-based radiolabeling, meaning that an in vivo redistribution of the daughter 140Pr is expected before positron emission. The purpose of this study was to determine how the delayed positron from the de-labeled 140Pr affects preclinical imaging with 140Nd. To explore the effect, 140Nd was produced at CERN-ISOLDE, reacted with the somatostatin analogue, DOTA-LM3 (1,4,7,10- tetraazacyclododecane, 1,4,7- tri acetic acid, 10- acetamide N - p…
Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography.
2010
Abstract SSR149415 was the first non-peptide vasopressin-(V1b) receptor antagonist reported. It has been used to probe the role of V1b receptors in animal models of depression, aggression, and stress-anxiety, and was progressed to clinical trials for the treatment of depression. Due to the interest in V1b receptors as a therapeutic target and the growing use of SSR149415 in preclinical research, we developed a method to label SSR145419 with carbon-11 and have studied its pharmacokinetics in non-human primates using positron emission tomography.
A comparative life-cycle assessment of asphalt mixtures for railway sub-ballast containing alternative materials
2018
Abstract Bituminous sub-ballast in railway track-bed can mitigate the variation of the moisture content in the subgrade and reduce vertical stiffness variations of the track leading to a more durable infrastructure. Nevertheless, durability is only one of the aspects that affects the sustainability of an infrastructure. Other relevant aspects are related to the environmental and economic issues. This research work joins the worldwide effort towards a paradigm shift in civil engineering devoted to assess the sustainability of infrastructures at the design stage. With this in mind, in this study different alternative bituminous sub-ballast mixtures containing recycled materials, namely crumb …