Search results for "ECL"

Presenilin is the molecular target of acidic γ-secretase modulators in living cells.

2012

The intramembrane-cleaving protease γ-secretase catalyzes the last step in the generation of toxic amyloid-β (Aβ) peptides and is a principal therapeutic target in Alzheimer's disease. Both preclinical and clinical studies have demonstrated that inhibition of γ-secretase is associated with prohibitive side effects due to suppression of Notch processing and signaling. Potentially safer are γ-secretase modulators (GSMs), which are small molecules that selectively lower generation of the highly amyloidogenic Aβ42 peptides but spare Notch processing. GSMs with nanomolar potency and favorable pharmacological properties have been described, but the molecular mechanism of GSMs remains uncertain an…

Experimental Investigation on Water Loss and Stiffness of CBTM Using Different RA Sources

2021

Cold recycling of reclaimed asphalt (RA) is a promising technique to build or to maintain roads, combining performance and environmental advantages. Although this technique has been extensively used worldwide, there is no unique and internationally-shared method to characterize cold recycled mixtures. The previous work of the RILEM TC 237-SIB TG6 successfully attempted to characterize different RA sources with both traditional parameters (gradation, bitumen content and geometrical properties) and non-conventional properties (fragmentation and strength testing). The current RILEM TC 264-RAP TG1 mainly focuses on the influence of different RA sources on physical and mechanical characteristics…

Ampliacion theologica de el parecer; y censurar que dieron los RR. PP. maestros de Predicadores sobre la incursion en las censuras de el derecho por …

1656

Copia digital : Diputación Provincial de Zaragoza. Servicio de Archivos y Bibliotecas, 2010 Datos de tít. tomados de p.1 Al final del texto aparece : "Convento de Predicadores" Sign.: A-F\p2\s Precede al texto en p.1 cruz de Malta

USING ROTATING SPRINKLER GUNS IN CENTRE‐PIVOT IRRIGATION SYSTEMS †

2019

The use of centre-pivot irrigation systems has significantly increased in the last few decades, since they are easier and less time-consuming to manage compared to other irrigation systems. Standard high-pressure impact sprinklers, low-pressure spray sprinklers or LEPA (Low Energy Precision Application) systems are usually combined with a centre-pivot irrigation system (CP-SYS). However, when applying waste water or with reclaimed effluents that are extremely dirty, small nozzle sizes that require CP-SYS could get plugged. As an alternative to common centre-pivot irrigation systems, this paper analyses the ‘geometry’ of areas irrigated by rotating sprinkler guns in a centre-pivot irrigation…

The isolated perfused rat brain as a model for studying drugs acting on the CNS

1974

An isolated perfused brain preparation is regarded as offering some important advantages over intact animals or tissue slices for studying drug effects on the CNS. The rat is by far the most suitable laboratory animal for this technique because of low cost, ease of preparation and extensive literature available for comparative purposes. In this paper various preparation techniques and perfusion systems for an isolated rat brain are reported. Investigations are presented proving the viability of the isolated perfused rat brain for more than seven hours and its suitability for studies on cerebral metabolism. Until now this preparation has been successfully used for pharmacological investigati…

In vivo Imaging of Fully Active Brain Tissue in Awake Zebrafish Larvae and Juveniles by Skull and Skin Removal.

2021

Understanding the ephemeral changes that occur during brain development and maturation requires detailed high-resolution imaging in space and time at cellular and subcellular resolution. Advances in molecular and imaging technologies have allowed us to gain numerous detailed insights into cellular and molecular mechanisms of brain development in the transparent zebrafish embryo. Recently, processes of refinement of neuronal connectivity that occur at later larval stages several weeks after fertilization, which are for example control of social behavior, decision making or motivation-driven behavior, have moved into focus of research. At these stages, pigmentation of the zebrafish skin inter…

Synthesis and inhibitory activity of dimethylamino-chalcone derivatives on the induction of nitric oxide synthase.

2002

A series of nine dimethylamino-chalcone derivatives (1,3-diaryl-propenones) was synthesized and screened as potential inhibitors of NO and PGE(2) production in the RAW 264.7 macrophage cell line. 4-Dimethylamino-2',5'-dimethoxychalcone (6) was found to be the most potent and dual inhibitor (IC(50s) in the submicromolar range) of NO and PGE(2) production. 2',6'-Dimethoxylation appeared to be an effective requirement for selective and potent inhibition of nitric oxide synthase induction as it was confirmed by Western blot analysis. Chalcone (6) at 25 mg kg(-1) by oral route, inhibited significantly the formation of oedema in the carrageenan-induced model of inflammation in mice.

Multifunctional nanocarriers for biomedical applications

2013

Polymeric vesicles (Pluronic ® L-121) loaded with magnetic nanoparticles (MNP) and an anti-cancer drug (camptothecin) were prepared continuously in a micro mixing device. Characterization by TEM confirmed the successful incorporation of the MNP and DLS measurements showed a relatively narrow size distribution of the hybrid polymersomes. A very high drug loading of camptothecin (100 μg/ml in the polymersome formulation) was reached and a drug release study of loaded magnetic polymersomes has shown a sustained camptothecin release over several days. Carboxylation of Pluronic ® L-121 was performed and enabled a further surface functionalization with bombesin, a 14 amino acid peptide, which bin…

Type B Aortic Dissection Diagnosed by Left-Sided Transthoracic Ultrasonography in a Woman With Preeclampsia

2017

AISF position paper on liver disease and pregnancy.

2016

Abstract The relationship between liver disease and pregnancy is of great clinical impact. Severe liver disease in pregnancy is rare; however, pregnancy-related liver disease is the most frequent cause of liver dysfunction during pregnancy and represents a severe threat to foetal and maternal survival. A rapid differential diagnosis between liver disease related or unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. This report summarizes the recommendation of an expert panel established by the Italian Association for the Study of the Liver (AISF) on the management of liver disease during pregnancy. The article provides an overview of liver disea…