Search results for "ECL"
showing 10 items of 1262 documents
New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
2019
The American Society for Pharmacology and Experimental Therapeutics has revised the Instructions to Authors for Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, and Molecular Pharmacology These revisions relate to data analysis (including statistical analysis) and reporting but do not tell investigators how to design and perform their experiments. Their overall focus is on greater granularity in the description of what has been done and found. Key recommendations include the need to differentiate between preplanned, hypothesis-testing, and exploratory experiments or studies; explanations of whether key elements of study design, such as sample size and …
Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors
2009
Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…
Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
2014
Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to maximize confidence in discovering hit matter within known bioactive chemical space, while incorporation of nonoverlapping substructures could offer novel hits in screening libraries. Using principal component analysis, polar and three-dimensional substructures display a higher-than-average enrichment of bioactive compounds, indicating increasing representation of these substructures may be beneficial in fragment …
Cronaca: Eloquentiae itinera. Declamazione e cultura letteraria nella Roma di età imperiale
2017
Sintesi dei contributi presentati al convegno Eloquentiae itinera. Declamazione e cultura letteraria nella Roma di età imperiale
Il salto sillabico. Dalle ottave del Meli al cunto di Mimmo Cuticchio
2019
Nei versi vernacolari del Meli ritroviamo la combinazione sillabica che possiamo definire salto sillabico o cambio di voce, perché impone nella declamazione un mutamento del grado e del tono della voce. Il cambio di voce o salto nel Meli si forma dalla mescolanza di sillabe di differente modalità, articolazione e grado, caratterizza il suono del verso e costruisce la variante tonale; nella quale si enuclea l’interpretazione del tema; inoltre il salto viene sottolineato con decisione grazie all’accostamento dei differenti gradi dell’articolazione delle sillabe. In alcune canzuni del Meli il salto cosiddetto sillabico affiora in presenza della mescolanza delle sillabe continue con quelle occl…
'Ignosce, non possum'. Modelli declamatori e topoi tragici a confronto: padri e figli tra declamazione e tragedia
2013
This paper deals with the links between Latin declamation and tragedy through the investigation of some controversiae, focusing on the relationship father-son. The comparison between some declamatories passages (Sen. contr. 1, 4 and Calp. exc. 18) and some Senecan tragic verses (from Thyestes and Phaedra) allows to detect the proximity between the rhetoric practiced in the schools of declamation and Senecan tragic theatre.
Declamazione e travestimento nello spettacolo letterario del Rinascimento
2017
L'articolo verte sulla natura della declamazione e del travestimento nello spettacolo letterario rinascimentale
Regalismo e inmunidad eclesiástica en la España del siglo XVIII: la resistencia del clero valenciano a la imposición del estanco del tabaco
2007
The charters abolition decree of the Kingdoms of Valencia and Aragon kept the traditional regulation on the jurisdiction and ecclesiastic immunity, and this exception was ratified in the Royal Order the 7th of September in 1707. As the members of this class thought that it was implying a reinforcement of their privileges, they presented an intense resistance to the imposition of the tobacco monopoly, which the monarchy considered as a «well-known royalty» inherent in its sovereignty. Initially, the opposition was assumed by the ecclesiastic hierarchy and it generated jurisdictional conflicts so serious that Philip V proceeded to the emission of dispositions in favour of his royal prerogativ…
Introduzione
2013
Design considerations of high RAP-content asphalt produced at reduced temperatures
2018
In many countries recycling of reclaimed asphalt pavement (RAP) for road surface layers is limited to a maximum of 10–30%. This is due to technical limitation of common asphalt plant but also to specifications that are still restrictive when it comes to increasing RAP in surface courses. The mistrust in this practice is mainly related to uncertainty in performance of these mixes as well as to existing fundamental issues with the mix design, especially when production temperatures are lowered. This paper analyses some of the factors affecting the design of warm asphalt mixtures for surface course layers containing 50% RAP, and suggests a framework to justify the common assumption of full ble…