Search results for "ECL"
showing 10 items of 1262 documents
Low-Dose Aspirin Use and Cognitive Function in Older Age: A Systematic Review and Meta-analysis
2017
Objectives:\ud \ud To investigate whether low-dose aspirin (<300 mg/d) can influence the onset of cognitive impairment or dementia in observational studies and improve cognitive test scores in randomized controlled trials (RCTs) in participants without dementia.\ud \ud Design:\ud \ud Systematic review and meta-analysis.\ud \ud Setting:\ud \ud Observational and interventional studies.\ud \ud Participants:\ud \ud Individuals with no dementia or cognitive impairment initially.\ud \ud Measurements:\ud \ud Odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for the maximum number of covariates from each study, were used to summarize data on the incidence of dementia and cognitive impa…
La “Donna di Ostuni”, a case of eclampsia 28,000 years ago?
2017
La "Donna di Ostuni", the Lady from Ostuni (fortified medieval city, on the southern Italian Adriatic coast) is the skeleton of "the human most ancient mother" ever found by paleoanthropologists, grave dated of 28,000 years BP. It concerns a 20-years-old woman buried with her baby in her womb estimated at 8 months gestation. To date, the cause of the maternal-fetal deaths is qualified of unknown origin. We propose that eclampsia may be a possible explanation for these deaths (mother and baby together). Eclampsia (convulsions), the curse of human births (non-existent in other mammals), has been described since writings has existed 5000 years ago in all civilisations. This plausible descripti…
L-citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia
2021
AbstractPreeclampsia, characterized by hypertension, proteinuria, and fetal growth restriction, is one of the leading causes of maternal and perinatal mortality. By far, there is no effective pharmacological therapy for preeclampsia. The present study was conducted to investigate the effects of L-citrulline supplementation in Dahl salt-sensitive rat, a model of superimposed preeclampsia. Parental DSSR were treated with L-citrulline (2.5 g/L in drinking water) from the day of mating to the end of lactation period. Blood pressure of the rats was monitored throughout pregnancy and markers of preeclampsia were assessed. Endothelial function of the pregnant DSSR was assessed by wire myograph. L-…
Changes in land use and physiological transitions of a Juniperus thurifera forest: from decline to recovery
2015
All Rights Reserved. Forest decline is frequently associated with infection; however, infections habitually affect trees that have been previously debilitated by environmental stress. Nevertheless, the causes and physiology of noninfectious forest decline are not well known. Some Juniperus thurifera L. forests presented severe (noninfectious) declines, with defoliations over 50%. The goal of this study was to determine the causes and characterize the physiology of this noninfectious decline, and we hypothesized that it could be related to environmental stress from increasing interspecific competition resulting from land abandonment. We randomly assigned60 trees to either a control group or …
The baculovirus display technology--an evolving instrument for molecular screening and drug delivery.
2008
High throughput screening is a core technology in drug discovery. During the past decade, several strategies have been developed to screen (poly)peptide libraries for diverse applications including disease diagnosis and profiling, imaging, as well as therapy. The recently established baculovirus display vector system (BDVS) represents a eukaryotic screening platform that combines the positive attributes of both cell and virus-based display approaches, allowing presentation of complex polypeptides on cellular and viral surfaces. Compared to microbial display systems, the BDVS has the advantage of correct protein folding and post-translational modifications similar to those in mammals, facili…
Shear-zone patterns and eclogite-facies metamorphism in the Mozambique belt of northern Malawi, east-central Africa: implications for the assembly of…
2002
Abstract We report on the first occurrence of Pan-African eclogite from the Mozambique belt of northern Malawi, east-central Africa. We describe aspects of (1) the pattern of Pan-African transcurrent and subhorizontal shear zones and how these shear zones relate to eclogite-facies metamorphism and (2) the P – T – t evolution of the eclogite. Finally, we discuss the significance of eclogite-facies metamorphism and shear-zone deformation for the assembly of Gondwana. The first major deformation event involved sinistral and dextral transcurrent and top-ESE shearing and occurred at ∼580–550 Ma. Transcurrent and top-ESE shearing resulted from ESE–WNW horizontal crustal shortening and commenced u…
Tra medioevo e prima età moderna: eclettismi nel Mediterraneo : Ecclettismo consapevole: alcuni casi di approfondimento.
2019
Coexistence and mixture phenomena of different architectural idioms in the early 1500s Sicily are not rare. The present essay evaluates two late Gothic masters, Antonio Belguardo and Girolamo Vicchiuzzo (his epigone), whose activity in Palermo and Alcamo protracts in various and "eclectic" buildings, which go beyond the first half of the XVIth century.
Oratio ad Sacrosanctum Oecumenicum Concilium Tridentinum, qua de ecclesiae auctoritate, et imitandis apostolis disseritur habita per... Gasparem A' F…
1563
Sign.: A4, B2
Obstetric and Neonatal Outcome of Pregnancies Fathered by Males on Immunosuppression After Solid Organ Transplantation
2015
Immunosuppressive drugs may influence spermatogenesis, but little is known about outcome of pregnancies fathered by transplanted males. We estimated risk of adverse outcomes in pregnancies (with data after the first trimester) fathered by males that had undergone organ transplantation and were treated with immunosuppression. A population-based study, linking data from the Norwegian transplant registry and the Medical Birth Registry of Norway during 1967-2009 was designed. All Norwegian men undergoing solid organ transplantation were included. Odds ratios for major malformations, preeclampsia, preterm delivery (<37 weeks) and small-for-gestational-age were obtained using logistic regression.…
Effects of leflunomide on immune responses and models of inflammation.
1993
Leflunomide is an antiphlogistic and immunomodulating agent that has been shown to be effective in preventing and healing autoimmune disorders and reactions leading to organ graft rejection. From our preliminary clinical data [4], we now have hopes that these effects, observed in experimental animals, can truly be transferred to humans. Although we are far from understanding the mode of action of leflunomide, we are slowly gathering some insight. A good many of the immunosuppressive effects of leflunomide can be attributed to the antagonistic effects it has on responses to many cytokines, most likely through receptor expression and signal transduction (tyrosine kinase inhibition). The inhib…