Search results for "ECL"

Extending the search for neutrino point sources with iceCube above the horizon

2009

Point source searches with the IceCube neutrino telescope have been restricted to one hemisphere, due to the exclusive selection of upward going events as a way of rejecting the atmospheric muon background. We show that the region above the horizon can be included by suppressing the background through energy-sensitive cuts. This approach improves the sensitivity above PeV energies, previously not accessible for declinations of more than a few degrees below the horizon due to the absorption of neutrinos in Earth. We present results based on data collected with 22 strings of IceCube, extending its field of view and energy reach for point source searches. No significant excess above the atmosp…

The effect of the geomagnetic field on cosmic ray energy estimates and large scale anisotropy searches on data from the Pierre Auger Observatory

2011

We present a comprehensive study of the influence of the geomagnetic field on the energy estimation of extensive air showers with a zenith angle smaller than $60^\circ$, detected at the Pierre Auger Observatory. The geomagnetic field induces an azimuthal modulation of the estimated energy of cosmic rays up to the ~2% level at large zenith angles. We present a method to account for this modulation of the reconstructed energy. We analyse the effect of the modulation on large scale anisotropy searches in the arrival direction distributions of cosmic rays. At a given energy, the geomagnetic effect is shown to induce a pseudo-dipolar pattern at the percent level in the declination distribution t…

Marquage de molécules biologiques par des complexes de radiométaux à base de polyamines macrocycliques

2012

This work conducted at the “Institut de Chimie Moléculaire de l’Université de Bourgogne” carries at first on the synthesis of bifunctional chelating agents suitable for the chelation of trivalent radiometals, including indium-111. The greater part of this work was then dedicated to the grafting of a DOTA derivative bifunctional chelating agent on different antibodies or fragments of monoclonal antibodies: trastuzumab (anti-HER2 treatment of breast cancer), cetuximab (anti EGFR, treatment of many cancers, including colorectal cancer) and abciximab (antiplatelet). Particular attention was paid to the characterization of various immunoconjugates. The critical step of this thesis consisted in t…

"Save the Night" : light footprint, urbanism and territorial governance

2010

Our society maintains a complex relation with night, space-time often outside the diurnal cadences which facilitates the reflection, the imagination, the creation, the listening and the link with the other one, while revealing the segregation, the fear, and thus the restriction. By this research, we put compared to the urban lighting – real light project carrier of a strong symbolism – the socio-cultural, ecological and sanitary costs engendered by the artificial light. The urban lighting generates a geographical interlacing of bright imprints of differentiated scales, which we approach by various modellings, without forbidding us the sensitive analysis. We clarify, at various scales, the g…

Buffon 1988

1992

“Ralph Waldo Emerson's Intellectual Declaration of Independence”

2003

Understanding Addiction Using Animal Models

2019

Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an extraordinary global economic impact. Despite decades of research, the options available to treat addiction are often ineffective because our rudimentary understanding of drug-induced pathology in brain circuits and synaptic physiology inhibits the rational design of successful therapies. This understanding will arise first from animal models of addiction where experimentation at the level of circuits and molecular biology is possible. We will review the most common preclinical models of addictive behavior and discuss the advantages and disadvantages of each. This includes non-contingent models in whi…

Investigating the Viability of Multi-Recycling of Asphalt Mixtures through a Preliminary Binder Level Characterization

2022

The incorporation of reclaimed asphalt (RA) in hot mix asphalt mixtures is widely considered a sustainable solution for road infrastructure development. Under the scope of the circular economy (CE), the multiple recycling capability of RA has to be assessed in order to ensure its performance at each recycling cycle and also its viability with different additives. The performance of asphalt mixtures with RA strongly depends on the type of rejuvenator, binder, and their degree of blending in the mix. For this reason, it is essential to know the properties of the aged binder extracted from RA to better understand its rheological properties and optimal dosage of rejuvenation to design a satisfa…

SENILE ANOREXIA IN DIFFERENT GERIATRIC SETTINGS IN ITALY

2010

Brain, cognition and physically active lifestyle in healthy ageing

2018

Normal ageing is accompanied by profound changes in brain structure and declines in the automatic processing of sensory stimuli, which in turn lead to altered cognitive performance. However, behaviour and lifestyle factors, such as physical activity, may help to maintain the brain’s structural connectivity and function, as well as cognitive functioning in old age. Study I examined the effects of age on the brain’s capability to detect changes in somatosensory stimuli by recording event-related potentials (ERPs) in response to electrical stimulation of different fingers in young and older adults. The results of Study I show that somatosensory mismatch response (sMMR) was attenuated in amplit…