Search results for "ECM"
showing 10 items of 50 documents
The Role of Assumptions in Ohlson Model Performance: Lessons for Improving Equity-Value Modeling
2021
In this paper, we test whether the short-run econometric conditions for the basic assumptions of the Ohlson valuation model hold, and then we relate these results with the fulfillment of the short-run econometric conditions for this model to be effective. Better future modeling motivated us to analyze to what extent the assumptions involved in this seminal model are not good enough approximations to solve the firm valuation problem, causing poor model performance. The model is based on the well-known dividend discount model and the residual income valuation model, and it adds a linear information model, which is a time series model by nature. Therefore, we adopt the time series approach. In…
The use of gerunds and infinitives in perceptive constructions
2016
In this article I compare the use of gerunds with perceptive verbs in Spanish and in Gardenese, a Rhaeto-Romance variety spoken in Northern Italy: perceptive gerunds are used as secondary predicates in Spanish, but as defective TP-complements in Gardenese. Following Rizzi’s (2014) account of parametric variation, I propose that the differences are due to the interplay of three parameters: a [+progressive] feature on Gardenese perception verbs, the pure lexical status of perception verbs in Gardenese and a [+Agreement] feature on Spanish gerunds. The discussion of the parameters involved leads to more general considerations, as a new proposal for the structure of perceptive ECMs in Romance, …
A disjunctive site of Sympecma paedisca (Brau.) (Odonata: Lestidae) in Opole Silesia (south-western Poland)
2013
The occurrence of Sympecma paedisca in a small water body in the Limestone Quarry “Gorazdze” was recorded in 2010. This site is interesting because of the anthropogenic nature of ecosystem and its location 50 km west of the known range of the species.
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
Kvantitatīvā stimulēšana eirozonā
2015
Sākoties Lielajai Recesijai, vairākas attīstīto ekonomiku centrālās bankas uzsāka nestandarta monetārās politikas operācijas, tostarp kvantitatīvo stimulēšanu. Lai nepieļautu eirozonas ekonomikas iekļūšanu deflācijas spirālē un sasniegtu savu galveno mērķi – uzturēt cenu stabilitāti, arī Eiropas Centrālā banka ir uzsākusi kvantitatīvas stimulēšanas pasākumus. Maģistra darba mērķis ir, pamatojoties uz ekonometrisko modeli, novērtēt kvantitatīvas stimulēšanas programmas ietekmi uz eirozonas ekonomiku un izteikt priekšlikumus monetārās politikas pilnveidošanai. Autora izstrādātā modeļa rezultāti liecina, ka kvantitatīvai stimulēšanai eirozonā būs nozīmīga pozitīva ietekme uz reģiona izlaidi un…
Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development.
2014
Abstract In the marine environment, manganese represents a potential emerging contaminant, resulting from an increased production of manganese-containing compounds. In earlier reports we found that the exposure of Paracentrotus lividus sea urchin embryos to manganese produced phenotypes with no skeleton. In addition, manganese interfered with calcium uptake, perturbed extracellular signal-regulated kinase (ERK) signaling, affected the expression of skeletogenic genes, and caused an increase of the hsc70 and hsc60 protein levels. Here, we extended our studies focusing on the temporal activation of the p38 mitogen-activated protein kinase (p38 MAPK) and the proteolytic activity of metalloprot…
TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD
2017
Background: The expression and localization of transforming growth factor-β (TGF-β) pathway proteins in different compartments of the lower airways of patients with stable COPD is unclear. We aimed to determine TGF-β pathway protein expression in patients with stable COPD. Methods: The expression and localization of TGF-β pathway components was measured in the bronchial mucosa and peripheral lungs of patients with stable COPD (n = 44), control smokers with normal lung function (n = 24), and control nonsmoking subjects (n = 11) using immunohistochemical analysis. Results: TGF-β1, TGF-β3, and connective tissue growth factor expression were significantly decreased in the bronchiolar epithelium…
Starpdisciplinārie pētījumi medicīnas koledžās : tēžu krājums
2021
Latvijas Universitātes 79. starptautiskās zinātniskās konferences “Starpdisciplinārie pētījumi medicīnas koledžās” tēzes raksturo medicīnas koledžās veikto pētījumu daudzpusību, pētniecības kvalitāti un arī lietišķumu, kas šogad izceļas ar raksturvārdiem “drošība” un “atbildība”. Konferencē prezentēto un diskutēto jautājumu loks ievērojami pārsniedz veselības aprūpē apskatīto jautājumu loku un veicinās studentus, pētniekus un sociālos partnerus aktīvāk sadarboties ne tikai studiju kvalitātes uzlabošanā, bet arī pētniecībā.
Electrogeneration of Diiodoaurate in Dimethylsulfoxide on Gold Substrate and Localized Patterning
2016
International audience; A localized etching of gold surface by scanning electrochemical microscope technique is presented where a dimethylsulfoxide-based electrolyte charged with iodine is used. The electrogenerated triiodide ion at the platinum ultramicroelectrode tip (feedback mode) acts as an oxidant for gold surface. The effects of electrode diameter and the bias time have been investigated. The approach curve method was used to hold the electrode tip close to the gold surface. A scanning electron microscope is used to observe the etched gold surfaces where disk-shaped dots are generated. The diameter of these holes depends directly on the Pt electrode diameter and the bias time.
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity
2012
Membrane microvesicle shedding is an active process and occurs in viable cells with no signs of apoptosis or necrosis. We report here that microvesicles shed by oligodendroglioma cells contain an ‘aggrecanase’ activity, cleaving aggrecan at sites previously identified as targets for adamalysin metalloproteinases with disintegrin and thrombospondin domains (ADAMTSs). Degradation was inhibited by EDTA, the metalloproteinase inhibitor GM6001 and by tissue inhibitor of metalloproteinases (TIMP)-3, but not by TIMP-1 or TIMP-2. This inhibitor profile indicates that the shed microvesicles contain aggrecanolytic ADAMTS(s) or related TIMP-3-sensitive metalloproteinase(s). The oligodendroglioma cells…