Search results for "ECM"

showing 10 items of 50 documents

Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.

2020

Abstract Background Throughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics’ infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. Approach We conducted conduct a systematic survey of various TCM herbal pre…

PTGS2 Prostaglandin-endoperoxide synthase 2BattleAIV avian influenza virusCoV coronavirusPharmaceutical ScienceiNOS nitric oxide synthaseViral infection0302 clinical medicinePA patchouli alcoholSARS Severe Acute Respiratory SyndromeSMD Sheganmahuang decoctionDrug DiscoveryPandemicIL InterleukinMedicine Chinese TraditionalALI acute lung injuriesmedia_commonCOVID-19 coronavirus disease 2019MXSG Ma xing shi gan decoction0303 health sciencesTNF tumor necrosis factorClinical Trials as TopicCCL2 CC chemokine ligand 2FM1 FM1 coronavirusICU intensive care unitc-AMP cyclic adenosine phosphateHIV human immunodeficiency virus030220 oncology & carcinogenesisCOX-2 cyclooxygenase-2Molecular MedicineHerbal preparationsMedicinal herbsAbbreviations: ACE2 angiotensin-converting enzyme IITCM traditional Chinese medicineHSV-1 herpes simplex virus 1CASP3 caspase 3medicine.medical_specialtyChinaCoronavirus disease 2019 (COVID-19)Systematic surveymedia_common.quotation_subjectJEV Japanese encephalitis virusNF-κB nuclear factor kappa B cellsAntiviral AgentsArticleWHO World Health Organization03 medical and health sciencesIEC-6 rat intestinal epithelial cell line 6SOD superoxide dismutaseCDC Center for Disease Control and PreventionmedicineAVP arginine vasopressinPGE2 prostaglandin E2HumansIntensive care medicineLH Lianhuaqingwen capsule030304 developmental biologyPharmacologyMedicinal herbMDA malondialdehydeGCGJ Gancao ganjiang decoctionNO nitric oxidePlants Medicinalbusiness.industrySARS-CoV-2COVID-19CXCL C-X-C- motif chemokineMDCK Madin-Darby Canine Kidney cellsTLR-4 Toll-like receptor-4COVID-19 Drug TreatmentComplementary and alternative medicineViral infectionLPS lipopolysaccharidesRSV respiratory syncytial virusQFPD Qingfeipaidu decoctionbusinessLung congestionECMO extracorporeal membrane oxygenationMAPK mitogen-activated protein kinasePhytotherapyDrugs Chinese HerbalPhytomedicine : international journal of phytotherapy and phytopharmacology
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Muscle degeneration in neuramindase 1 deficient mice results from infiltration of the muscle fibers by expanded connective tissue

2010

AbstractNeuraminidase 1 (NEU1) regulates the catabolism of sialoglycoconjugates in lysosomes. Congenital NEU1 deficiency in children is the basis of sialidosis, a severe neurosomatic disorder in which patients experience a broad spectrum of clinical manifestations varying in the age of onset and severity. Osteoskeletal deformities and muscle hypotonia have been described in patients with sialidosis. Here we present the first comprehensive analysis of the skeletal muscle pathology associated with loss of Neu1 function in mice. In this animal model, skeletal muscles showed an expansion of the epimysial and perimysial spaces, associated with proliferation of fibroblast-like cells and abnormal …

Pathologymedicine.medical_specialtyMuscle HypotoniaMuscle Fibers SkeletalNeuraminidaseConnective tissueApoptosisNEU1BiologyArticleMiceNecrosisNEU1SarcolemmaCell MovementSettore BIO/10 - BiochimicamedicineAnimalsSialidosisMuscular dystrophyMyopathyMolecular BiologySialidosiMetalloproteinaseCell ProliferationMice KnockoutMuscle biopsySialidosisECMmedicine.diagnostic_testSkeletal muscleFibroblastsMuscular Dystrophy Animalmedicine.diseaseLysosomeExtracellular MatrixMuscular Atrophymedicine.anatomical_structureConnective TissueImmunologyMolecular MedicineMuscle biopsymedicine.symptom
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Acute respiratory distress syndrome in traumatic brain injury: how do we manage it?

2017

Abstract: Traumatic brain injury (TBI) is an important cause of morbidity and mortality worldwide. TBI patients frequently suffer from lung complications and acute respiratory distress syndrome (ARDS), which is associated with poor clinical outcomes. Moreover, the association between TBI and ARDS in trauma patients is well recognized. Mechanical ventilation of patients with a concomitance of acute brain injury and lung injury can present significant challenges. Frequently, guidelines recommending management strategies for patients with traumatic brain injuries come into conflict with what is now considered best ventilator practice. In this review, we will explore the strategies of the best …

Pulmonary and Respiratory Medicinemedicine.medical_specialtyARDSTraumatic brain injurymedicine.medical_treatmentReview ArticleLung injury03 medical and health sciencesAcute respiratory distress syndrome (ARDS); Extra corporeal membrane oxygenation (ECMO); Positive end expiratory pressure (PEEP); Traumatic brain injury (TBI); Pulmonary and Respiratory Medicine0302 clinical medicineTraumatic brain injury (TBI); acute respiratory distress syndrome (ARDS); extra corporeal membrane oxygenation (ECMO); positive end expiratory pressure (PEEP)medicineExtracorporeal membrane oxygenationTraumatic brain injury (TBI)Intensive care medicinePositive end-expiratory pressureMechanical ventilationpositive end expiratory pressure (PEEP)Lungbusiness.industryextra corporeal membrane oxygenation (ECMO)acute respiratory distress syndrome (ARDS)030208 emergency & critical care medicinemedicine.diseaseProne positionmedicine.anatomical_structurebusiness030217 neurology & neurosurgeryJournal of thoracic disease
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A Hydrogel Derived From Decellularized Dermal Extracellular Matrix. Biomaterials

2012

The ECM of mammalian tissues has been used as a scaffold to facilitate the repair and reconstruction of numerous tissues. Such scaffolds are prepared in many forms including sheets, powders, and hydrogels. ECM hydrogels provide advantages such as injectability, the ability to fill an irregularly shaped space, and the inherent bioactivity of native matrix. However, material properties of ECM hydrogels and the effect of these properties upon cell behavior are neither well understood nor controlled. The objective of this study was to prepare and determine the structure, mechanics, and the cell response in vitro and in vivo of ECM hydrogels prepared from decellularized porcine dermis and urinar…

ScaffoldHydrogelCell viabilityViscoelasticityECM (extracellular matrix)Surface topography
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Preparation and characterization of a biologic scaffold from esophageal mucosa

2013

Biologic scaffolds composed of extracellular matrix (ECM) are commonly used to facilitate a constructive remodeling response in several types of tissue, including the esophagus. Surgical manipulation of the esophagus is often complicated by stricture, but preclinical and clinical studies have shown that the use of an ECM scaffold can mitigate stricture and promote a constructive outcome after resection of full circumference esophageal mucosa. Recognizing the potential benefits of ECM derived from homologous tissue (i.e., site-specific ECM), the objective of the present study was to prepare, characterize, and assess the in-vivo remodeling properties of ECM from porcine esophageal mucosa. The…

ScaffoldPathologymedicine.medical_specialtySwineBiophysicsBioengineeringArticleBiomaterialsExtracellular matrixECM (extracellular matrix) Decellularization Scaffold Immune responseEsophagusTissue engineeringMaterials TestingmedicineAnimalsEsophagusCells CulturedBasement membraneDecellularizationMucous MembraneTissue EngineeringTissue Scaffoldsbusiness.industrySoft tissueExtracellular MatrixRatsmedicine.anatomical_structureMechanics of MaterialsCeramics and CompositesMicroscopy Electron ScanningStem cellbusiness
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TGFbeta signaling: roles of Smads

2009

TGFbeta Smads COPD ECMSettore BIO/16 - Anatomia Umana
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Endoscopy at Bedside in Isolated Patients with Severe COVID-19: Our Approach during the Pandemic

2021

The COVID-19 pandemic changed the management of emergency medicine and those complications that needed interventional procedures, such as endoscopy or other radiological procedures. At the beginning of the outbreak, there were no exploitable recommendations regarding the proper policy to apply for limiting the virus spread during endoscopy. Between the first and the second wave, the approach regarding interventional procedures changed, due to higher awareness and newly defined protocols, even if different among the health centers. Patients with severe COVID-19 may develop major gastrointestinal complications or require nutritional support, so interventional procedures are required at bedsid…

TechnologyCoronavirus disease 2019 (COVID-19)QH301-705.5QC1-999gas exchangesGastrointestinal complicationsPandemicMedicineGeneral Materials ScienceinfectionsendoscopyBiology (General)QD1-999InstrumentationFluid Flow and Transfer Processeseducation in ECMOmedicine.diagnostic_testbusiness.industryECMO transportationTPhysicsProcess Chemistry and TechnologyGeneral EngineeringLimitingEngineering (General). Civil engineering (General)medicine.diseaseComputer Science ApplicationsEndoscopyChemistryRadiological weaponMedical emergencyTA1-2040businesspatient selectionApplied Sciences
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Dzemdībpalīdzība Latvijas Republikā 1920-1940: Rīgas 1.slimnīcas piemērs

2019

Rīgas 1. slimnīca bija ļoti nozīmīga ārstniecības iestāde 20. gs. sākumā Rīgā. Tieši Rīgas 1. slimnīcā izveidota pirmā dzemdību un ginekoloģijas klīnika Rīgā un dibināta pirmā Vecmāšu skola Latvijā, kas ir svarīgs aspekts veselības aprūpes sistēmas attīstībā valstī, liekot pamatus dzemdībpalīdzībai ne tikai Rīgas, bet visiem Latvijas iedzīvotājiem. Bakalaura darba mērķis ir pētīt un analizēt dzemdībpalīdzību Latvijas Republikā laika posmā no 1920. līdz 1940. gadam un raksturot to ar Rīgas 1. slimnīcas Dzemdību nodaļas piemēru. Historiogrāfijā šī tēma nav pietiekami pētīta no sociālekonomiskā skatu punkta. Darbā apskatīta demogrāfiskā situācija Latvijā 1920. 1940. gadā, pētīta dzemdībpalīdzī…

Vecmāšu skoladzemdībpalīdzībavecmātesVēstureRīgas 1. slimnīcadzemdības
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Sarkandaugavas, Jaunmīlgrāvja un Vecmīlgrāvja ģeogrāfisks apraksts

1937

Vecmīlgrāvis (Rīga Latvija)ĢeogrāfijaJaunmīlgrāvis (Rīga Latvija)Diplomdarbi:SOCIAL SCIENCES::Business and economics::Human geography economic geography [Research Subject Categories]Rīgas rajoni - ģeogrāfijaMīlgrāvis (Rīga Latvija)Ģeogrāfija ekonomiskāRiga districts - geography:NATURAL SCIENCES::Earth sciences::Exogenous earth sciences::Physical geography [Research Subject Categories]Sarkandaugava (Rīga Latvija)
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