Search results for "EDC"
showing 4 items of 134 documents
Latest Developments and Results of Radiation Tolerance CMOS Sensors with Small Collection Electrodes
2020
The development of radiation hard Depleted Monolithic Active Pixel Sensors (DMAPS) targets the replacement of hybrid pixel detectors to meet radiation hardness requirements of at least 1.5e16 1 MeV neq/cm2 for the HL-LHC and beyond. DMAPS were designed and tested in the TJ180 nm TowerJazz CMOS imaging technology with small electrodes pixel designs. This technology reduces costs and provides granularity of 36.4x36.4 um2 with low power operation (1 uW/pixel), low noise of ENC < 20 e-, a small collection electrode (3 um) and fast signal response within 25 ns bunch crossing. This contribution will present the latest developments after the MALTA and Mini-MALTA sensors. It will illustrate the imp…
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining
2012
Purpose: The aim of this study was to demonstrate that modern data mining tools can be used as one step in reducing the labor necessary to produce and maintain systematic reviews. Methods: We used four continuously updated, manually curated resources that summarize MEDLINE-indexed articles in entire fields using systematic review methods (PDGene, AlzGene, and SzGene for genetic determinants of Parkinson disease, Alzheimer disease, and schizophrenia, respectively; and the Tufts Cost-Effectiveness Analysis (CEA) Registry for cost-effectiveness analyses). In each data set, we trained a classification model on citations screened up until 2009. We then evaluated the ability of the model to class…
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…
Assessment of environmental pollution caused by EDCs from everyday objects
2016
Związki modulujące pracę hormonów estrogenowych są grupą związków chemicznych, które przez ostatnich kilka dekad zwróciły uwagę zarówno społeczeństwa, jak i naukowców. Dowiedziono, że substancje te ingerują w prawidłową pracę układu hormonalnego i zaburzają rozwój, reprodukcję, homeostazę i metabolizm żywych organizmów. Zagrażają nie tylko ludziom, ale także wszystkim żywym organizmom. Są obecne w: plastikach, między innymi plastikowych opakowaniach na żywność, detergentach, pestycydach, tworzywach ognioodpornych, metalach ciężkich, a także farmaceutykach i produktach codziennej higieny, takich jak kosmetyki - kremy czy mydła, filtry UV, doustne środki antykoncepcyjne i przeciwbólowe, a tak…