Search results for "EFA"
showing 10 items of 1142 documents
Predicting Cryptocurrency Defaults
2019
We examine all available 146 Proof-of-Work based cryptocurrencies that started trading prior to the end of 2014 and track their performance until December 2018. We find that about 60% of those cryptocurrencies were eventually in default. The substantial sums of money involved mean those bankruptcies will have an enormous societal impact. Employing cryptocurrency-specific data, we estimate a model based on linear discriminant analysis to predict such defaults. Our model is capable of explaining 87% of cryptocurrency bankruptcies after only one month of trading and could serve as a screening tool for investors keen to boost overall portfolio performance and avoid investing in unreliable crypt…
La miniera dell'architettura
2010
The essay traces the main events and themes of the journal « In Architettura. Il giornale della progettazione» founded in Cefalù by Pasquale Culotta. Up until 1993, the year of publication of the last issue, the periodical represented a precious place for debate and comparison, a tool for questioning oneself on the profession of architect, on the sense of doing and teaching, as well as than an opportunity to establish contacts with distant realities, making the young Sicilian architecture an internationally known avant-garde.
On Conditions Instantiating Tip Effects of Epistemic and Evidential Meanings in Bulgarian
2012
Статья посвящена условиям, при которых происходит попеременная актуализация то эвиденциального, то эпистемического компонента в семантическом потенциале эвиденциальных показателей болгарского языка. Сосредоточиваясь на сентенциальных наречиях с инферентивными функциями, мы опираемся на следующие предпосылки: (i) для каждой единицы следует отличать её устойчивое семантическое значение от прагматического потенциала, выявлению которого способствуют (или препятствуют) те или иные коммуникативные условия; (ii) эвиденциальные и эпистемические компоненты значения довольно легко вытесняют друг друга из позиции доминанты, причём процесс подавления то одного, то другого компонента обусловлен действие…
Objetos-testigo. Fracturas y reconstrucciones del relato identitario
2020
The presentation will be divided into three movements: fractures, reconstructions and archives. Each movement will correspond to a different typology of objects: shoes, nails and beams, clothes. The aim is to show the process of defamiliarization/refamiliarization of some of the objects present in the testimonial stories of Miguel Lawner ( Return to Isla Dawson ) and Marta Dillon ( Aparecida ), as well as in a corpus of photographic images ((Javier Garcia, Lourdes Almeida, Gustavo Gutierrez) and artistic and performative works (Alfredo Lopez Casanova, Colectivo de Hijos, Elina Chauvet, Doris Salcedo). As a whole, they are objects that exhibit resistance and resilience, creations that are op…
Efavirenz: What is known about the cellular mechanisms responsible for its adverse effects
2017
The HIV infection remains an important health problem worldwide. However, due to the efficacy of combined antiretroviral therapy (cART), it has ceased to be a mortal condition, becoming a chronic disease instead. Efavirenz, the most prescribed non-nucleoside analogue reverse transcriptase inhibitor (NNRTI), has been a key component of cART since its commercialization in 1998. Though still a drug of choice in many countries, its primacy has been challenged by the arrival of newer antiretroviral agents with better toxicity profiles and treatment adherence. The major side effects related to EFV have been widely described in clinical studies, however the mechanisms that participate in their pat…
Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz
2014
Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main side effects attributed to efavirenz involve the CNS, but the underlying mechanisms are unclear. Methods. Human cell lines and rat primary cultures of neurons and astrocytes were treated with clinically relevant efavirenz concentration. Results. Efavirenz alters mitochondrial respiration, enhances reactive oxygen species generation, undermines mitochondrial membrane potential, and reduces adenosine triphosphate (ATP) levels in a concentration-dependent fashion in both neurons and glial cells. However, it activates adenosine monophospha…
Profile of stress and toxicity gene expression in human hepatic cells treated with Efavirenz
2012
Hepatic toxicity and metabolic disorders are major adverse effects elicited during the pharmacological treatment of the human immunodeficiency virus (HIV) infection. Efavirenz (EFV), the most widely used non-nucleoside reverse transcriptase inhibitor (NNRTI), has been associated with these events, with recent studies implicating it in stress responses involving mitochondrial dysfunction and oxidative stress in human hepatic cells. To expand these findings, we analyzed the influence of EFV on the expression profile of selected stress and toxicity genes in these cells. Significant up-regulation was observed with Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), which indicated m…
[Pharmacogenomics of antiretrovirals].
2008
HIV infection is a serious but treatable disease, yet current treatment is limited by development of resistance and high rates of adverse drug reactions. Antiretroviral therapy is especially suitable for pharmacogenomic investigation as both drug exposure and treatment response can be reliably measured. Increasing knowledge about genes implicated in pharmacokinetics, mode of action, efficacy, and toxicity of drugs has already provided relevant results for clinical practice, for example: The strong association of the abacavir hypersensitivity reaction with HLA-B*5701 permits testing patients for the allele, and if present avoiding the drug and therefore preventing the reaction. Persons with …
Autophagy as a rescue mechanism in efavirenz-induced mitochondrial dysfunction: a lesson from hepatic cells.
2011
Efavirenz (EFV) is the most widely used non-nucleoside reverse transcriptase inhibitor applied in highly active antiretroviral therapy (HAART), the combined pharmacological treatment of the human immunodeficiency virus infection. Its use has been associated with the development of several adverse events including hepatotoxicity. The molecular pathogenesis of this effect is poorly understood but recent reports have highlighted features of mitochondrial dysfunction in hepatic cells exposed to clinically relevant concentrations of EFV. In this study, we investigated the activation of autophagy and, in particular, mitophagy, in human hepatic cells exposed to EFV. We detected the presence of alt…
Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy
2011
Hepatotoxicity is a very common side effect associated with the pharmacological treatment of human immunodeficiency virus (HIV) infection and its pathogenesis is poorly understood. Efavirenz (EFV) is the most widely used nonnucleoside reverse transcriptase inhibitor administered for the control of HIV and some of its toxic effects in hepatic cells have been recently shown to display features of mitochondrial dysfunction. Here we studied the activation of autophagy and, in particular, mitophagy, the main mitochondrial turnover mechanism, in human hepatic cells treated with clinically relevant concentrations of this drug. EFV-treated cells had altered mitochondria, characterized by a relative…