Search results for "EFFICACY"

Identifying predictors of response to liraglutide in type 2 diabetes using recursive partitioning analysis

2014

Beliefs and preferences regarding biological treatments for severe asthma

2020

Background: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as throu…

Efficacy of Low-Dose Paroxetine for the Treatment of Hot Flushes in Surgical and Physiological Postmenopausal Women: Systematic Review and Meta-Analy…

2019

Background and Objectives: Hot flushes and sleep disturbances are the most common vasomotor symptoms (VMS) reported by postmenopausal women. Hormonal treatment is to date referred to as the gold standard approach but not suitable for all the patients. Alternative treatments are needed in case of a contraindication to menopausal hormone therapy (MHT), adverse side effects, and poor compliance. Paroxetine salt is the only nonhormonal medication approved by the US Food and Drug Administration for the management of VMS. Nonetheless, few trials with low consensus are available about this topic. In this review, we aimed to evaluate the efficacy of low-dose paroxetine therapy in the treatment of v…

Ten-year follow-up on efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine or one dose of monovalen…

2020

Abstract Background We assessed the 10-year efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV) or one dose of a monovalent varicella vaccine (V) in children from Czech Republic, Lithuania, Poland, Romania and Slovakia. Methods This was a phase IIIB follow-up of an observer-blind, randomized, controlled trial (NCT00226499). In phase A, healthy children aged 12–22 months from 10 European countries were randomized in a 3:3:1 ratio to receive two doses of MMRV (MMRV group), one dose of MMR followed by one dose of V (MMR + V group), or two doses of MMR (MMR; control group), 42 days apart. Vaccine efficacy (VE) against varicella (confirme…

Neue Therapieoption für akute hepatische Porphyrien

2021

Was ist neu? Therapie mit Givosiran Givosiran ist ein kleines synthetisches doppelsträngiges siRNA-Fragment mit 20 Basenpaaren Länge. Eine prospektive, randomisierte multizentrische Studie (Envision) zeigte erstmalig die klinische Wirksamkeit von monatlich subkutan applizierten synthetischen RNA-Molekülen („small interfering“ RNA, siRNA) zur Prävention von Attacken bei akuten hepatischen Porphyrien (AHP) 2. Die Koppelung von siRNA-Molekülen an N-Acetyl-Galaktosamin (GalNAc) und die hierdurch leberspezifische Aufnahme durch den Asialoglykoprotein-Rezeptor auf Hepatozyten sind ein Meilenstein in der Hepatologie. Dies führt zu einer hochselektiven Inhibition der Translation der bei AHP überexp…

Self-Efficacy, Planning, or a Combination of Both? A Longitudinal Experimental Study Comparing Effects of Three Interventions on Adolescents’ Body Fat

2016

Author(s): Luszczynska, Aleksandra; Hagger, Martin S; Banik, Anna; Horodyska, Karolina; Knoll, Nina; Scholz, Urte | Abstract: BackgroundThe superiority of an intervention combining two sets of theory-based behavior change techniques targeting planning and self-efficacy over an intervention targeting planning only or self-efficacy only has rarely been investigated.PurposeWe compared the influence of self-efficacy, planning, and self-efficacy+planning interventions with an education-based control condition on adolescents' body fat, assuming mediating effects of respective social cognitive variables and moderate-to-vigorous physical activity (MVPA). The moderating role of the built environment…

Career pursuit pathways among emerging adult men and women : Psychosocial correlates and precursors

2014

The present study examined career pursuit pathways in 100 Israeli emerging adults (54 men) who were followed from age 22 to 29. Employing a semi-structured interview at the age of 29, participants were asked about current work and educational status, work and educational goals and status changes in recent years, and to reflect on the meaning of the processes they followed. Analyses of interviews yielded four distinctive career pursuit pathways that were associated with different levels of concurrent well-being: Consistent Pursuit, Adapted Pursuit, Survivors, and Confused/Vague. Self-criticism, efficacy, and level of motivation measured seven years earlier predicted pathway affiliation at 2…

Can reading fluency and self-efficacy of reading fluency be enhanced with an intervention targeting the sources of self-efficacy?

2018

Abstract The first aim of the study was to analyze whether reading fluency and self-efficacy of reading fluency (SE-rf) are malleable for children (Grades 3–5) with deficits in fluent reading via a 12-week special education program targeting both reading fluency and the sources of SE-rf (SE-program). The second aim was to investigate whether changes in SE-rf are related to changes in reading fluency. The SE-program (n = 40) was contrasted with the SKILL-program (n = 42) providing training solely in reading fluency. The groups showed equal improvements in reading fluency. Positive change in SE-rf emerged only in the SE-group, and this change was associated with changes in fluency, but the as…

Interaction through social media: Development and validation of a social network site self-efficacy scale (SNS-SES)

2023

Today, more than ever before, awareness of our ability to interact with others through and use social network sites (SNSs) is of fundamental importance, in light of the fact that we are connected to the Web 24 h a day, 7 days a week. Studies of social media in recent decades have shown that self-efficacy is one of the key variables affecting individual online behavior. The general aim of the studies presented here was to develop and validate a new self-report scale measuring self-efficacy in SNS use (an SNS self-efficacy scale, or SNS-SES). Across two studies, a total of 1295 Italian adolescents and adults (ages 15 to 89; M = 38.21, SD = 15.6) participated. The SNS-SES consists of 24 items …

A Validation Study of Classroom Assessment Scoring System–Secondary in the Finnish School Context

2017

This study examined the reliability and validity of the Classroom Assessment Scoring System–Secondary (CLASS-S) in Finnish classrooms. Trained observers coded classroom interactions based on video recordings of 46 Grade 6 classrooms (450 cycles). Concurrent associations were investigated with respect to teacher self-ratings (e.g., efficacy beliefs and teaching-related stress). Confirmatory factor analysis showed that the hypothesized three-factor structure of the original CLASS-S (Emotional Support, Organizational Support, and Instructional Support), with some modifications, provided a better fit for the data compared with one- and two-factor structures. Structural validity was demonstrate…