Search results for "EKIN"
showing 10 items of 195 documents
Language complexity in on-line health information retrieval
2020
The number of people searching for on-line health information has been steadily growing over the years so it is crucial to understand their specific requirements in order to help them finding easily and quickly the specific in-formation they are looking for. Although generic search engines are typically used by health information seekers as the starting point for searching information, they have been shown to be limited and unsatisfactory because they make generic searches, often overloading the user with the provided amount of results. Moreover, they are not able to provide specific information to different types of users. At the same time, specific search engines mostly work on medical li…
ULearn: Personalized Medical Learning on the Web for Patient Empowerment
2019
Abstract. Health literacy constitutes an important step towards patient empowerment and the Web is presently the biggest repository of medical information and, thus, the biggest medical resource to be used in the learning process. However, at present web medical information is mainly accessed through generic search engines that do not take into account the user specific needs and starting knowledge and so are not able to support learning activities tailored to the specific user requirements. This work presents “ULearn” a meta engine that supports access, understanding and learning on the Web in the medical domain based on specific user requirements and knowledge levels towards what we call …
Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice
2016
Binge eating is a specific form of overeating characterized by intermittent excessive eating. In addition to altering the neurobiological reward system, several studies have highlighted that consumption of palatable food increases vulnerability to drug use. The aim of the present study was to evaluate the effects of a high-fat diet consumed in a binge pattern during adolescence on the reinforcing effects of cocaine. After 40 days of binge-eating for 2 h, three days a week (PND 29–69), the reinforcing effects of cocaine on conditioning place preference and intravenous self-administration paradigm were evaluated in adolescent male mice. Circulating leptin and ghrelin levels and the effects of…
Physical activity and environmental enrichment: Behavioural effects of exposure to different housing conditions in mice.
2020
Enriched environments and exercise provide complex environmental stimulation that can induce emotional and cognitive changes; however, few studies have evaluated the effects of these two components on other behaviours, such as novelty seeking or pain sensitivity. The aim of the present study was to investigate the influence of voluntary physical activity provided through different housing conditions on anxiety, locomotor activity, pain sensitivity, and exploration. Male mice at postnatal day (PND) 21 and were randomly assigned to one of four different conditions on PND 28: Marlau cages (MC), a standardized cage designed to provide a complex environment; physical exercise in large groups (PE…
Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death.
2017
Hepatocellular carcinoma (HCC) is a malignant primary liver cancer with poor prognosis. In the present study, we report that pekinenin E (PE), a casbane diterpenoid derived from the roots of Euphorbia pekinensis, has a strong antitumor activity against human HCC cells both in vitro and in vivo. PE suppressed the growth of human HCC cells Hep G2 and SMMC-7721. In addition, PE-mediated endoplasmic reticulum (ER) stress caused increasing expressions of C/EBP homologous protein (CHOP), leading to apoptosis in HCC cells both in vitro and in vivo. Inhibition of ER stress with CHOP small interfering RNA or 4-phenyl-butyric acid partially reversed PE-induced cell death. Furthermore, PE induced S ce…
Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
2020
Summary The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been implicated in reward seeking. However, the precise molecular and physiological basis of reward-seeking behavior remains unknown. We found that the specific deletion of metabotropic glutamate receptor 5 (mGluR5) in D1-expressing MSNs (D1miRmGluR5 mice) abolishes eCB-mediated long-term depression (LTD) and prevents the expression of drug (cocaine and ethanol), natural reward (saccharin), and brain-stimulation-seeking behavior. In vivo enhancement…
Psychological predictors of homophobic bullying among adolescents and young adults: The role of parental psychological control and sensation seeking
2021
AbstractWe aimed to investigate the relationship between homophobic bullying, parental psychological control and sensation seeking among adolescents and young adults and to examine the mediating role of sensation seeking. The participants included 394 adolescents and young adults aged 15 to 20 years attending the 3rd, 4th and 5th years of two public high schools in Italian cities. Participants completed the Homophobic Bullying Scale, the Dependency—oriented and Achievement—oriented Parental Psychological Control, and the Sensation—Seeking Scale. The results showed that parental psychological control predicted bullying toward gay and lesbian people. However, the two dimensions of sensation s…
Groupthink and Project Performance: The Influence of Personal Traits and Interpersonal Ties
2015
Contains fulltext : 166103.pdf (Publisher’s version ) (Closed access) This study explores whether the negative impact of “groupthink concurrence-seeking behavior” (GTB) on business process reengineering (BPR) projects is affected by group members personal traits and interpersonal ties within the group. To this purpose we conduct and present the results of a longitudinal controlled field experiment over 18 BPR projects lasting 3 months and involving 18 teams comprising 71 first-year MBA students. The main contribution of this study is twofold. First, we explicitly consider and measure the core construct of groupthink phenomenon: that is, GTB. Existing organizational behavior literature has, …
Evaluation der Sexual Sensation Seeking Scale: Ergebnisse einer repräsentativen deutschen Bevölkerungsumfrage
2021
ZusammenfassungBisherige Studien zu Sexual Sensation Seeking (SSS) und der Sexual Sensation Seeking Scale (SSSS) wurden überwiegend an nach dem Alter sowie dem Geschlecht selektierten Stichproben durchgeführt. In dieser Arbeit wurde die deutsche Version der SSSS anhand einer repräsentativen Umfrage an Männern und Frauen evaluiert, welche die gesamte Altersspanne der erwachsenen deutschen Bevölkerung umfasst. Die Gütekriterien und die Faktorenstruktur der deutschen Version der Sexual Sensation Seeking Scale wurden anhand einer repräsentativen Stichprobe von N=2420 Probanden (54% Frauen, 46% Männer) im Alter von 18–93 Jahren (M=50,44, SD=16,97) untersucht. Die SSSS zeigt gute Werte hinsichtli…
Psychometric properties and validation of the sexual sensation seeking scale in Spanish adolescents: Brief screening method for use in research and c…
2018
Abstract Sexual sensation seeking among adolescents has been mostly associated with unprotected sex and other risky behaviors. This paper presents the Spanish adaptation and validation of the Sexual Sensation Seeking Scale (SSSS). This cross-sectional study included 1350 adolescents (601 male and 749 female), aged between 15 and 18 years ( M = 16.1, SD = 0.97). Exploratory Factor Analysis (EFA) yielded two components: Physical Sensations Attraction (PSA), and New Experiences Seeking (NES), which together accounted for 48.98% of the total variance. That structure was later verified through Confirmatory Factor Analysis (CFA). Internal consistency was 0.82 for the total scale, and 0.76 and 0…