Search results for "ELF"
showing 10 items of 5893 documents
Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation
2021
ABSTRACTRadial glial progenitor cells (RGCs) in the dorsal forebrain directly or indirectly produce excitatory projection neurons and macroglia of the neocortex. Recent evidence shows that the pool of RGCs is more heterogeneous than originally thought and that progenitor subpopulations can generate particular neuronal cell types. Using single cell RNA sequencing, we have studied gene expression patterns of two subtypes of RGCs that differ in their neurogenic behavior. One progenitor type rapidly produces postmitotic neurons, whereas the second progenitor remains relatively quiescence before generating neurons. We have identified candidate genes that are differentially expressed between thes…
Pumice powder as filler of self-compacting concrete
2015
Abstract An experimental study on the rheological and mechanical properties of self-compacting concrete with pumice powder used as filler additive is presented. Self-compacting concrete (SCC) shows its peculiar characteristics in the fresh state and many researches have been developed with reference to its rheological characteristics paying attention to the techniques of self-compacting properties assessment. One of the most important aspect in concrete mix-design is the type and the amount of fillers with respect to water and cement: this amount has great influence not only on self-compacting properties (fluidity, segregation, etc.), but also on the mechanical properties of the mixture. Vo…
Recent Development on Self-Cleaning Cementitious Coatings
2013
The recent improvements in nano-technologies applied to building coatings are reported, starting from the historical origins of the research on photocatalysis. The description of the main air pollutants and the chemical mechanism of photocatalysis introduce to self-cleaning surfaces and the super-hydrophilic and hydrophobic attitude. Self-cleaning cementitious surfaces, due to nano-structured photocatalysts, mainly titanium dioxide, show environmental benefit in reduction of air pollutants and many experimental evidences are reported together with several applications on building construction. International standards and main spectroscopic techniques aim to evaluate the benefit in terms of …
Sucrose self-administration and CNS activation in the rat
2011
We have previously reported that administration of insulin into the arcuate nucleus of the hypothalamus decreases motivation for sucrose, assessed by a self-administration task, in rats. Because the pattern of central nervous system (CNS) activation in association with sucrose self-administration has not been evaluated, in the present study, we measured expression of c-Fos as an index of neuronal activation. We trained rats to bar-press for sucrose, according to a fixed-ratio (FR) or progressive-ratio (PR) schedule and mapped expression of c-Fos immunoreactivity in the CNS, compared with c-Fos expression in handled controls. We observed a unique expression of c-Fos in the medial hypothalam…
Experimental Study of Central Baffle Flume
2019
In this paper, the hydraulics of a central baffle flume (CBF) were experimentally studied. Extensive experimental runs were carried out to highlight the effects of different geometrical parameters such as baffle length, contraction ratio, and the length of upstream and downstream guide walls. Two different approaches, i.e., the Π theorem of dimensional analysis coupled with the incomplete self-similarity theory and the energy balance equation, were applied to deduce the stage–discharge formula of a CBF characterized by different geometrical parameters. The stage–discharge relationship deduced by the dimensional analysis approach was more accurate than that obtained by the energy approach. F…
Retuning the Nordic Welfare Municipality: Central Regulation of Social Care under Change in Finland
2011
Purpose – The purpose of this paper is to analyse the changes that have taken place in the central regulation of social care in Finland since the 1970s. The changes in vertical central‐local relations are discussed in the context of economic and welfare state development.Design/methodology/approach – The paper is a case study, applying the concept of “the Nordic welfare municipality” to the case of Finland. With this concept, the author refers to the inherently contradictory character of the Nordic model of welfare governance: to a system that emphasises local self‐government but that, at the same time, perceives regional harmonisation as imperative.Findings – After strong central control d…
Trophic ecology of the swimming crab Polybius henslowii Leach, 1820 in Galician and Cantabrian Seas: Influences of natural variability and the Presti…
2008
9 pages, 9 figures, 2 tables.-- Printed version published Nov 15, 2008.
Effect of bioglass on growth and biomineralization of SaOS-2 cells in hydrogel after 3D cell bioprinting.
2014
We investigated the effect of bioglass (bioactive glass) on growth and mineralization of bone-related SaOS-2 cells, encapsulated into a printable and biodegradable alginate/gelatine hydrogel. The hydrogel was supplemented either with polyphosphate (polyP), administered as polyP • Ca2+-complex, or silica, or as biosilica that had been enzymatically prepared from ortho-silicate by silicatein. These hydrogels, together with SaOS-2 cells, were bioprinted to computer-designed scaffolds. The results revealed that bioglass (nano)particles, with a size of 55 nm and a molar ratio of SiO2 : CaO : P2O5 of 55 : 40 : 5, did not affect the growth of the encapsulated cells. If silica, biosilica, or polyP …
The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.
2021
Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that in the developing cerebellum Tie2 expression is not restricted to blood vessels, but it is also present in PCs. Its ligands angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are expressed in neural cells and endothelial cells (ECs), respectively. PC-specific deletion of Tie2 results in reduced dendritic arborization, which is recapitulated in neural-specific Ang1-knockout and Ang2 full-knockout mice. Mechanistically, RNA sequencing reveals that Tie…
Capitolo VIII della Carta dell’ONU e modelli di azione militare regionale
2019
This contribution deals with relations between regional organizations and the UN Security Council under Chapter VIII of the UN Charter. In this respect, the most recent trends are a shift from subsidiarity to a more equal partnership between these two subjects. The two models of action by delegation or authorization of the Security Council are in fact autonomous. This is demonstrated by the preparatory works of the UN Charter and subsequent practice. The model of authorized regional action enriches the range of instruments that the United Nations Charter provides for the maintenance of peace and collective security.