Search results for "ELS"

Two component chiral gels: a study of properties and behavior as recognition systems

Cracking the Code : The Impact of Orthographic Transparency and Morphological-Syllabic Complexity on Reading and Developmental Dyslexia

2019

On some partial data Calderón type problems with mixed boundary conditions

2021

In this article we consider the simultaneous recovery of bulk and boundary potentials in (degenerate) elliptic equations modelling (degenerate) conducting media with inaccessible boundaries. This connects local and nonlocal Calderón type problems. We prove two main results on these type of problems: On the one hand, we derive simultaneous bulk and boundary Runge approximation results. Building on these, we deduce uniqueness for localized bulk and boundary potentials. On the other hand, we construct a family of CGO solutions associated with the corresponding equations. These allow us to deduce uniqueness results for arbitrary bounded, not necessarily localized bulk and boundary potentials. T…

Variational parabolic capacity

2015

We establish a variational parabolic capacity in a context of degenerate parabolic equations of $p$-Laplace type, and show that this capacity is equivalent to the nonlinear parabolic capacity. As an application, we estimate the capacities of several explicit sets.

Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.

2005

Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …

Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation

2009

We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …

Feedback and Communication in Active Hydrogel Spheres with pH Fronts: Facile Approaches to Grow Soft Hydrogel Structures

2021

Abstract Compartmentalized reaction networks regulating signal processing, communication and pattern formation are central to living systems. Towards achieving life‐like materials, we compartmentalized urea‐urease and more complex urea‐urease/ester‐esterase pH‐feedback reaction networks into hydrogel spheres and investigate how fuel‐driven pH fronts can be sent out from these spheres and regulated by internal reaction networks. Membrane characteristics are installed by covering urease spheres with responsive hydrogel shells. We then encapsulate the two networks (urea‐urease and ester‐esterase) separately into different hydrogel spheres to devise communication, pattern formation and attracti…

PHOTOCROSSLINKING OF DEXTRAN AND POLYASPARTAMIDE DERIVATIVES: A COMBINATION SUITABLE FOR COLON- SPECIFIC DRUG DELIVERY.

2007

The aim of this study was to prepare and characterize novel hydrogels with polysaccharide–polyaminoacid structure, able to undergo an enzymatic hydrolysis in the colon and potentially useful for treating inflammatory bowel diseases (IBD). Starting materials were methacrylated dextran (DEX-MA) and methacrylated α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHM). These polymers were photocrosslinked by exposure of their aqueous solutions at 313 nm without photoinitiators. Different samples, shaped as microparticles, were obtained as a function of polymer concentration and irradiation time. FT-IR analysis confirmed the occurrence of a co-crosslinking between DEX-MA and PHM in all experimental con…

Slanginimet Hesa ja Stadi Suomi24-keskusteluissa : korpusonomastinen kurkistus

2020

Nimet Hesa ja Stadi mielletään melko latautuneiksi, ja niihin liitetään paljon mielikuvia. Monilla on myös käsitys siitä, ketkä näitä nimiä käyttävät. Mutta millaisia ovat näihin slanginimiin liittyvät keskustelut todellisuudessa? Kurkistus Suomen suosituimmalle keskustelupalstalle paljastaa, mistä puhutaan silloin, kun Helsingistä puhutaan slanginimillä. nonPeerReviewed

NMDA receptor antagonists and pain relief: A meta-analysis of experimental trials

2019

ObjectiveWe conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of NMDA receptor (NMDAR) antagonists.MethodsSix major databases were systematically searched (to March 2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis.ResultsSearches identified 70 eligible trials (n = 1,069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease in hyperalgesic area (standardized mean difference 0.54, 95% confidence interval [CI] 0.34, 0.74, p < 0.001) and a 1.2-point decr…