Search results for "ELS"

Nais- ja miesurheilijan representointi Helsingin Sanomissa vuoden 2004 Ateenan olympialaisten kontekstissa

2006

Revisiting the “The Breakfast Club”: Testing Different Theoretical Models of Belongingness and Acceptance (and Social Self-Representation)

2021

The current work tests different theoretical models of belongingness and acceptance as fundamental needs for human motivation. In the current study, 372 participants were presented with 52 different items measuring five different theoretical models of belongingness (with a total of 32 items) and three different theoretical models of acceptance (with a total of 20 items). In a first step, Confirmatory Factor Analysis (CFA) failed to provide support for these eight theoretical models. In a second step, we therefore applied Exploratory Factor Analysis yielding three factors, which we interpreted as communicating: (1) Belongingness, (2) Emotion-Acceptance, and (3) Social Self-Representation. In…

A methodology for the control of the residual lifetimes of carbon fibre reinforced composite pressure vessels

2005

International audience; Pressure vessels must be periodically proof tested. Traditional techniques for metal vessels are inapplicable for composite vessels as the latter do not break by crack propagation so that the reasoning behind the traditional testing procedures is not appropriate. Damage accumulation leading to the degradation of a composite vessel is by fibre failure. Fibres show a wide distribution in strengths and loading a composite inevitably breaks some. The method which has been developed is supported by an analysis of delayed fibre failure due to the relaxation of the resin around fibre breaks. This provokes overloading of intact fibres neighbouring breaks. The time until a cr…

ESTIMATION OF ATTRIBUTE IMPORTANCE BY CHOICE TIME IN A RANKING TASK

2010

The evaluation of the quality of products and services as a function of their attributes has been broadly implemented in marketing research. The current methods for identifying important attributes and prioritize them suffer from theoretical and practical limitations. The former are related to the choice of the most appropriate model for the specific experimental context, the latter are due to the large amount of variables (cognitive, context and survey variables) affecting the chosen model. This work aims at presenting a new method for capturing consumer attribute preferences and estimating the relative importance weights by using the choice time in a ranking task. All is made through an e…

Talentutvikling i fotball : kan et opplevd motivasjonsklima predikere behovstilfredsstillelse og selvregulert læring hos unge talentfulle fotballspil…

2016

Masteroppgave i idrettsvitenskap - Universitetet i Agder 2016 Studies that have looked at the relationship between training and performance have sown that athletes must practice at lot in order to reach a high level (Côté et al., 2007; Ericsson et al., 1993; Simon & Chase, 1973), and motivation is viewed as an important factor in order to implement the required training. Through satisfaction of the basic needs of autonomy, competence and relatedness, athletes will feel self-determination and intrinsic motivation (Deci & Ryan, 1985). Furthermore, football players who spend more time promoting their own learning is often preferred over players taking less responsibility (Toering et al., 2012)…

Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-α blockers: The GI…

2007

OBJECTIVE: To assess the prevalence of good clinical response and remission in rheumatoid arthritis (RA) patients with longstanding disease treated with anti-tumor necrosis factor-alpha (TNF-alpha) drugs at outpatient clinics. METHODS: Retrospective national study of 14 academic tertiary referral rheumatology medical centers. RA patients with a Disease Activity Score (DAS28) > 3.2 were defined as having active disease and could start TNF-alpha blockers. All patients received one TNF-alpha blocker plus methotrexate (10-20 mg/wk). At the third month the patients were categorized as responders or nonresponders, based on improvement of at least 0.25 of the Health Assessment Questionnaire (HAQ).…

Targeting the mevalonate pathway for improved anticancer therapy.

2009

The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho) GTPases. These low molecular GTP-binding proteins play key roles in numerous signal transduction pathways stimulated upon activation of cell surface receptors by ligand binding. Thus, Ras/Rho proteins eventually regulate cell proliferation, tumor progression and cell death induced by anticancer therapeutics. Lipid modification of Ras/Rho pro…

A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo

2015

AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…

Korsuista kodittomuuteen. Rintamasotilaat asunnonhakijoina sodanjälkeisessä Helsingissä

2011

Helsinki ajautui vakavaan asuntokriisiin vuoden 1944 lopulla. Vähävaraiset perheelliset rintamasotilaat olivat suurin asuntoa tarvitseva ryhmä. Vaikka viranomaisten toimintavaltuuksia laajennettiin ja asuntojen käyttöä pyrittiin tehostamaan, sadat reserviläisperheet joutuivat sinnittelemään vaikeissa olosuhteissa. Avunsaannin pitkittyessä viranomaistoiminnan oikeudenmukaisuus kyseenalaistettiin. Rintamasotilaat ja heidän omaisensa kokivat julkisen vallan rikkoneen lupauksensa vastavuoroisuudesta: sotavuosina kannettu vastuu ei tuonutkaan heille vastapalvelusta, oikeutta kelvolliseen asumiseen. peerReviewed

Nitrate and nitrite in the diet: How to assess their benefit and risk for human health

2015

Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However…