Search results for "ELS"
showing 10 items of 12690 documents
Tumor targeting of baculovirus displaying a lymphatic homing peptide.
2008
Background Tumor-associated cells and vasculature express attractive molecular markers for site-specific vector targeting. To attain tumor-selective tropism, we recently developed a baculovirus vector displaying the lymphatic homing peptide LyP-1, originally identified by ex vivo/in vivo screening of phage display libraries, on the viral envelope by fusion to the transmembrane anchor of vesicular stomatitis virus G-protein. Methods In the present study, we explored the specificity and kinetics of viral binding and internalization as well as in vivo tumor homing of the LyP-1 displaying virus to elucidate the applicability of baculovirus for targeted therapies. Results We demonstrated that th…
(A,B) In vivo GCaMP6f signals recorded in layers M1, M5 and M9/10 of Mi1 (A) and Tm3 (B) neurons, before (blue, green) and after (gray, red) applicat…
2019
Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specifi…
MODELING OF VOLATILITY IN THE ROMANIAN CAPITAL MARKET
2012
This paper aims to analyze the volatility of capital market in Romania by selecting a portfolio of representative indices (BET BET_FI and RASDAQ_C). In this respect, we want to identify the most appropriate model to estimate volatility by using modern econometric tools and useful GARCH models respectively. The study results highlight that EGARCH(1,1) model has managed to eliminate all traces of statistically significant autocorrelation and ARCH effects from the residuals from daily series, giving an accurate image of the Romanian capital market volatility.
Ultraviolet imaging of volcanic plumes: A new paradigm in volcanology
2017
Ultraviolet imaging has been applied in volcanology over the last ten years or so. This provides considerably higher temporal and spatial resolution volcanic gas emission rate data than available previously, enabling the volcanology community to investigate a range of far faster plume degassing processes than achievable hitherto. To date, this has covered rapid oscillations in passive degassing through conduits and lava lakes, as well as puffing and explosions, facilitating exciting connections to be made for the first time between previously rather separate sub-disciplines of volcanology. Firstly, there has been corroboration between geophysical and degassing datasets at â1 Hz, expeditin…
Anàlisi sobre la figura/institució del Comissionat del menor: Pare d'Òrfens contemplada a la Llei 12/2008 de Protecció a la infància i l'adolescència…
2012
The concept / institution of the Commissioner for Children ' 'Pare d'Òrfens' appears for the first time in Valencia with Law 12/2008 on Protection of Children and Adolescents. The purpose of this article is to inform readers of the existence of this concept / institution, analysing the regulatory development that has taken place and comparing its performance with other similar concepts/institutions existing in other Spanish regions, in order to critically assess the work done in recent years. To close the paper, we give a number of conclusions drawn after completing the research on this concept / institution, including several general recommendations in the form of constructive criticism.
The relationships between urbanization and bird functional traits across the streetscape
2023
Publisher Copyright: © 2023 The Authors The urbanization process leads to changes in bird communities’ taxonomic and functional compositions. Highly urbanized areas generally exhibit a reduced number of bird species sharing few functional traits. However, most urban bird studies focused on vegetation patches in temperate cities. In this study, we investigate how urban environmental attributes – noise, height of buildings, and urban vegetation characteristics – modulate species occurrences and the distribution of functional traits across the streetscape of a tropical metropolis. We predicted diverse trait-environment relationships, but that highly urbanized contexts (e.g., noisy streets with…
Maggie Nelson: Sinelmiä
2019
Kirja-arvostelu teoksesta Maggie Nelson: Sinelmiä, suom. Kaijamari Sivill, S&S 2019 nonPeerReviewed
Predator response to the coloured eyespots and defensive posture of Colombian four‐eyed frogs
2023
Deimatic displays, where sudden changes in prey appearance elicit aversive predator reactions, have been suggested to occur in many taxa. These (often only putative) displays frequently involve different components that may also serve antipredator functions via other mechanisms (e.g., mimicry, warning signalling, body inflation). The Colombian four-eyed frog, Pleurodema brachyops, has been suggested to gain protection against predation through putative deimatic displays where they inflate and elevate the posterior part of their body revealing eye-like colour markings. We exposed stationary artificial frogs to wild predators to test whether the two components (eyespot/colour markings, defens…
Mīļais Misiņa kungs!
1914
Vēstulē P. Šmits stāsta par "Etnografisku rakstu krājuma" 2. daļas rakstiem, kā arī lūdz bibliofilu J. Misiņu pameklēt A. Hupeļa rakstu, atsūtīt kalendāru 1914. gadam. Tie varētu būt gan P. Strautzeļa, gan Zvārguļa vai J. Gūžas sastādītie kalendāri. Vēl lūgums pēc "Dienas Lapas" etnogrāfiskajiem pielikumiem.
The effect of aquatic exercise on symptoms, function, body composition and cartilage in knee osteoarthritis
2016
Knee osteoarthritis (OA) is the most common joint disease associated with pain and loss of functional capacity. The management of knee OA is multifaceted and covers the whole OA continuum from injury prevention to the end stage of the disease. Recently, specific focus has been on preventing the progression of cartilage degeneration and avoiding loss of function in the early phase of the disease via the provision of exercise interventions. Aquatic exercise is a popular but under-researched exercise option. Therefore, the purpose of this dissertation was to investigate the role of aquatic exercise in the management of knee OA, focusing especially the effect it evokes on both functional capaci…