Search results for "ELT"

Control of Gastric Acid Secretion in Somatostatin Receptor 2 Deficient Mice: Shift from Endocrine/Paracrine to Neurocrine Pathways

2007

The gastrin-enterochromaffin-like (ECL) cell-parietal cell axis is known to play an important role in the regulation of gastric acid secretion. Somatostatin, acting on somatostatin receptor type 2 (SSTR2), interferes with this axis by suppressing the activity of the gastrin cells, ECL cells, and parietal cells. Surprisingly, however, freely fed SSTR2 knockout mice seem to display normal circulating gastrin concentration and unchanged acid output. In the present study, we compared the control of acid secretion in these mutant mice with that in wild-type mice. In SSTR2 knockout mice, the number of gastrin cells was unchanged; whereas the numbers of somatostatin cells were reduced in the antru…

Thrombopoietin Receptor Agonists for Severe Thrombocytopenia after Allogeneic Stem Cell Transplantation: Experience of a Multicenter Study from the G…

2018

Abstract Introduction Thrombocytopenia is a common complication after allogeneic hematopoietic stem cell transplantation (allo-SCT). Underlying mechanisms are poorly known and usually multifactorial. Its treatment is not well defined, mostly based in platelet transfusion. Thus, is important to identify new strategies to manage this important post-SCT complication. Romiplostim and Eltrombopag are currently available thrombopoietin receptor agonists (TPO-RAs) that stimulate platelet production. Some studies with very small number of cases have reported their potential efficacy in the allo-SCT setting. For this reason, the aim of our study is to analyze the efficacy and safety of TPO-RAs for s…

The sleep EEG's microstructure in depression: alterations of the phase relations between EEG rhythms during REM and NREM sleep

2002

Abstract Objective : We investigated the microstructure of sleep electroencephalograms (EEGs) of 13 unmedicated depressive inpatients and 13 healthy controls matched in sex and age, hypothesizing that depressives depict an alteration of certain EEG oscillations across the night. Methods : We digitized the sleep EEGs with a sampling rate of 100Hz (bipolar derivation C z –P z , 1440 single sweeps; 2048 data points each), calculated the time course of delta (1–3.5Hz), theta (3.5–7.5Hz), alpha (7.5–15Hz), and beta (15–35Hz) activity over the night, and determined the correlation coefficients of these different EEG rhythms separately for rapid eye movement (REM) and non-rapid eye movement (NREM)…

The Orienting Response in Healthy Aging: Novelty P3 Indicates No General Decline but Reduced Efficacy for Fast Stimulation Rates

2017

Automatic orienting to unexpected changes in the environment is a pre-requisite for adaptive behavior. One prominent mechanism of automatic attentional control is the Orienting Response (OR). Despite the fundamental significance of the OR in everyday life, only little is known about how the OR is affected by healthy aging. We tested this question in two age groups (19–38 years and 55–72 years) and measured skin-conductance responses (SCRs) and event-related brain potentials (ERPs) to novels (i.e., short environmental sounds presented only once in the experiment; 10% of the trials) compared to standard sounds (600 Hz sinusoidal tones with 200 ms duration; 90% of the trials). Novel and standa…

Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effect…

2005

We have compared four human subsets of Vgamma9Vdelta2 T cells, naive (T(naive), CD45RA(+)CD27(+)), central memory (T(CM), CD45RA(-)CD27(+)), effector memory (T(EM), CD45RA(-)CD27(-)) and terminally differentiated (T(EMRA), CD45RA(+)CD27(-)), for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Cytokine responsiveness and IL-15R expression were low in T(naive) cells and progressively increased from T(CM) to T(EM) and T(EMRA) cells. In contrast, the capacity to expand in response to antigen or cytokine stimulation showed a reciprocal pattern and was associated with resistance to cell death and Bcl-2 expression. Whereas antigen-stimulated cells a…

Melt-spun conductive fibers containing functionalized CNTs

2013

Multifunctional fibers based on polyamide 6 and plasma functionalized carbon nanotubes.

2013

Melting point, molecular symmetry and aggregation of tetrachlorobenzene isomers: the role of halogen bonding

2018

Tetrachlorobenzenes represent one of the best known, but not yet fully understood, group of isomers of the structure–melting point relationship. The differences in melting temperatures of these structurally related compounds were rationalized in terms of the hierarchy and nature of formed noncovalent interactions, and the molecular aggregation that is influenced by molecular symmetry. The highest melting point is associated with the highly symmetric 1,2,4,5-tetrachlorobenzene isomer. The structures of less symmetrical 1,2,3,4-tetrachlorobenzene and 1,2,3,5-tetrachlorobenzene, determined at 270 and 90 K, show a distinct pattern of halogen bonds, characterized by the different numbers and typ…

LA PERCEZIONE DEL BARBARICUM. LIBANIO E LA REALTÀ EXTRA ANTIOCHENA

2015

This paper aims at exploring both the city of Antioch in the 4th century ad as a transit city, thus a melting-pot of cultures, and Libanius the rhetor: but they will be considered with regard to the extra- Antiochian context. Between the lines of Libanius’speeches emerges the primary function of the Empire, that is to say the defence of the polis – a perfect microcosm – against barbarian hordes, observed according to classical stereotypes. Much has already written about Libanius’ image deformation of barbaric peoples, influenced by literary tradition: nevertheless, a careful analysis of his works will show some ability to place them in the wake of Libanius’ coeval climate, especially when t…

Home and mental ill-health: twenty dimensions

2017

In the context of psychiatric rehabilitation and care, home is often associated with health. In the context of deinstitutionalization, however, home has increasingly become the primary site of psychiatric suffering. Drawing on a two-year ethnographic research project with a drama group for young adult mental healthcare service users living in supported housing facilities, this paper presents twenty dimensions of home through which mental ill-health can be approached as a bodily experienced, and discursively and medically structured form of being in the world. These dimensions are here offered as a framework for further exploration of the social, spatial, temporal, structural and embodied as…