Search results for "ELT"

This can be made more student-centred : Asynchronous mediation in in-service teacher professional development

2022

Vygotskian Sociocultural Theory is a powerful foundation for research into teacher professional development. However, while this research has been growing, it has largely been focused on pre-service second/foreign language. Furthermore, there is a lack of research on how the instructional process informed by the principles of Sociocultural Theory, including assessment of candidates’ mediated performance, can be orchestrated to promote teachers’ conceptual development and induce changes in their classroom practices. The present study explores how asynchronous assessment of in-service teachers’ portfolios (with the focus on lesson planning) informed by dynamic assessment framework shaped the …

A Multimedia Museum Application Based Upon a Landscape Embedded Digital 3D Model of an Ancient Settlement

2012

This paper describes the development of a digital reconstruction of the celtic hillfort “Altburg” (Germany), which was generated in the context of a museums exhibition in the Hunsruck-Museum Simmern (Germany). This model refers to the City GML standard and considers the principles of the London Charter for establishing internationally recognized principles for the use of three-dimensional visualization by researchers, educators and cultural heritage organizations.

Chemotherapy Sensitizes Colon Cancer Initiating Cells to Vγ9Vδ2 T Cell-Mediated Cytotoxicity

2013

Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops. Combinations of immune-based therapies with chemotherapy and other anti-tumor agents may be of significant clinical benefit in the treatment of colon cancer. However, cellular immune-based therapies have not been experimented yet in the population of colon CICs. Here, we demonstrate that treatment with low concentrations of commonly used chemotherapeutic agents, 5- fluorouracyl and doxorubicin, sensitize colon CICs to Vc9Vd2 T cell cytotoxicity. Vc9Vd2 T cell cytotox…

γδ T cells as a potential tool in colon cancer immunotherapy

2014

γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the…

Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes

2009

Colon cancer comprises a small population of cancer stem cells (CSC) that is responsible for tumor maintenance and resistant to cancer therapies, possibly allowing for tumor recapitulation once treatment stops. We previously demonstrated that such chemoresistance is mediated by autocrine production of IL-4 through the up-regulation of antiapoptotic proteins. Several innate and adaptive immune effector cells allow for the recognition and destruction of cancer precursors before they constitute the tumor mass. However, cellular immune-based therapies have not been experimented yet in the population of CSCs. Here, we show that the bisphosphonate zoledronate sensitizes colon CSCs to Vgamma9Vdelt…

γδ T cell-based anticancer immunotherapy: Progress and possibilities

2015

"Table 2" of "Study of ordered hadron chains with the ATLAS detector"

2017

The Delta(3h), for 3-hadron chains with mass below 0.59 GeV, as a function of $Q$, in the interval 0.02 GeV < Q < 0.36 GeV.

"Table 1" of "Measurements of the charge asymmetry in top-quark pair production in the dilepton final state at $\sqrt{s}=8$ TeV with the ATLAS detect…

2017

Unfolded distribution for the inclusive $\Delta|\eta|$ observable in the fiducial volume.

"Table 1" of "Study of ordered hadron chains with the ATLAS detector"

2017

The inclusive Delta as a function of $Q$, in the interval 0.02 GeV < Q < 2 GeV.

"Table 12" of "Constraints on jet quenching in p-Pb collisions at $\mathbf{\sqrt{s_{NN}}}$ = 5.02 TeV measured by the event-activity dependence of se…

2018

Ratio of event activity biased Delta_{recoil} distributions corresponding to recoil jets with R=0.4.