Search results for "EMU"

Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of r…

2015

BackgroundAcquired resistance to BRAF inhibitors (BRAFi) is a near-universal phenomenon caused by numerous genetic and non-genetic alterations. In this study, we evaluated the spectrum, onset, pattern of progression, and subsequent clinical outcomes associated with specific mechanisms of resistance.MethodsWe compiled clinical and genetic data from 100 patients with 132 tissue samples obtained at progression on BRAFi therapy from 3 large, previously published studies of BRAFi resistance. These samples were subjected to whole-exome sequencing and/or polymerase chain reaction-based genetic testing.ResultsAmong 132 samples, putative resistance mechanisms were identified in 58%, including NRAS o…

Radiotherapy with BRAF inhibitor therapy for melanoma: progress and possibilities.

2015

The introduction of small molecule BRAFV600 kinase inhibitors represents a milestone in the targeted therapy of patients with metastatic melanoma by a significant increase in therapeutic efficacy in terms of overall and progression-free survival compared with conventional chemotherapy. Beside BRAFV600 inhibitor treatment, radiotherapy is a further mainstay for the therapy of metastatic melanoma and thus a concomitant or sequential application of BRAFV600 inhibitors and radiotherapy is inevitable. Recent reports show a significant radiosensitization of the irradiated healthy tissue in patients with melanoma after the combination of radiotherapy and BRAFV600 inhibitors, evoking concern in cl…

Targeted Therapies in Melanoma

2015

The standard approach for malignant melanoma is represented by surgical excision. In most cases, distant metastases develop. Until few years ago, the main strategies to treat metastatic melanoma were chemotherapy and cytokines with subsequent low efficacy and poor tolerability profile. In the last few years, a new biological therapy has become available for metastatic melanoma. It includes targeted therapy, such as BRAF inhibitors (vemurafenib and dabrafenib) and MEK inhibitors (trametinib), and immunotherapy, such as the monoclonal antibodies anti-CTLA-4 (ipilimumab) and anti-PD-1 (nivolumab and lambrolizumab). The different mechanisms of action of these new drugs imply a variability of ou…

Quality-of-life (QoL) in COLUMBUS part 1: A phase 3 trial of encorafenib (ENCO) plus binimetinib (BINI) versus vemurafenib (VEM) or ENCO in braf-muta…

2017

Predictability of intraocular lens power calculation after small-incision lenticule extraction for myopia

2019

PURPOSE To evaluate and compare the predictability of intraocular lens (IOL) power calculation after small-incision lenticule extraction (SMILE) for myopia and myopic astigmatism. SETTING Department of Ophthalmology, Philipps University of Marburg, Marburg, Germany. DESIGN Retrospective comparative case series. METHODS Preoperative evaluation included optical biometry using IOLMaster 500 and corneal tomography using Pentacam HR. The corneal tomography measurements were repeated at 3 months postoperatively. The change of spherical equivalent due to SMILE was calculated by the manifest refraction at corneal plane (SMILE-Dif). A theoretical model, involving the virtual implantation of the same…

Correlation between optics quality of multifocal intraocular lenses and visual acuity

2009

Purpose To study the relationship between the optics quality of multifocal intraocular lenses (IOLs) and distance-corrected near, intermediate, and distance visual acuity to determine the degree to which optics quality must change to produce a significant difference in visual acuity. Setting Fundacion Oftalmologica del Mediterraneo, Valencia, Spain. Methods Monocular distance-corrected visual acuity (decimal and logMAR) was measured at 4 m, 70 cm, and 30 cm under photopic and mesopic conditions in eyes with 1 of 3 multifocal IOL models. Visual acuity versus the “average modulation” of the IOL was assessed. Results The pupil diameter and patient age were similar between the 3 IOL groups (20 …

Keho käyntiin ja musisoimaan : tutkimus kehorytmiikan ja Orff-pedagogisten lähtökohtien soveltuvuudesta peruskoulun yläluokkien musiikinopetukseen

2006

Integrating human resource management into lean production and their impact on organizational performance

2011

PurposeThe first goal of this research is to analyse the effects of lean production (LP) on the policy of human resource management (HRM). The second is to determine whether or not implementation of HRM practices associated with LP explains the differences in organizational performance between manufacturing plants.Design/methodology/approachThe paper developed a questionnaire for data collection. Findings are presented from 76 establishments (79.17 per cent of the total sample) that specialise in single‐firing ceramic tiles in Spain.FindingsCompanies that make the most of LP practices are also those that take care to train workers in using these practices as well as improving their employme…

Flexible Wage Contracts, Temporary Jobs, and Firm Performance: Evidence From Italian Firms

2013

This study focuses on the effects of decentralized wage schemes and temporary forms of employment on firm performance. The effect of monetary incentives on workers' effort and firm performance is a central topic in economics. According to the principal-agent paradigm, firms (the principal) have to link employees' remuneration schemes to any verifiable indicator of performance to avoid opportunistic behavior. The empirical evidence shows that financial incentives have the potential to exert strong effects on indicators of firm performance, such as productivity and worker absenteeism, although the degree of effectiveness of such schemes varies significantly according to the institutional/econ…

Some determinants of salesforce effectiveness

2008

PurposeThis paper aims to find out what characterises salespeople in the most effective salesforce in Spain.Design/methodology/approachAn empirical analysis has been done with 108 field sales managers from different sectors of activity to determine the conditions of the salesperson's control, professionalism and behaviour that affect his/her performance and the effectiveness of companies. A structural equations model or second generation multivariate model was used – PLS.FindingsThe results show that more effective salesforces are controlled through behaviour control systems, salespersons in this team identify with the company's strategic objectives and an important part of their remunerati…