Search results for "ENDOMETRIO"
showing 10 items of 150 documents
A Critical Perspective on the Supplementation of Akkermansia muciniphila: Benefits and Harms
2023
Akkermansia muciniphila is a mucin-degrading bacterium of the intestinal niche, exerting beneficial effects on the host metabolic profile. Accumulating evidence indicated Akkermansia as a promising therapeutic probiotic against metabolic disorders such as obesity, type 2 diabetes and cardiovascular diseases. However, in specific intestinal microenvironments, its excessive enrichment may be not beneficial. Conditions like inflammatory bowel disease (IBD), Salmonella typhimurium infection or post-antibiotic reconstitution may not benefit from Akkermansia supplementation. Furthermore, using Akkermansia in patients with endocrine and gynecological disorders—such as polycystic ovary syndrome (PC…
Trattato di chirurgia ostetrica e ginecologica
2019
L’endometriosi è una malattia benigna e cronica caratterizzata dalla presenza di tessuto endometriale funzionale (ghiandole endometriali e stroma) al di fuori dell’utero (1). La presenza di malattia endometriosica è un problema sociale significativo, in quanto causa nelle donne affette deficit di fertilità, dolore pelvico cronico, dispareunia, disuria e dischezia (2). Con il termine neuropelveologia si intende quel complesso di pratiche mediche che si occupano delle patologie che interessano l’innervazione pelvica nel suo complesso. La disciplina, nata da un’intuizione di Possover all’inizio degli anni 2000, ha preso prepotentemente piede negli ultimi anni come sub-specialità trasversale ai…
Evaluation of Peri-Operative Management in Women with Deep Endometriosis Who are Candidates for Bowel Surgery: A Survey from the Italian Society of G…
2023
Study objective: There is great consensus that the implementation of ERAS approach is beneficial for surgical patients, but there is paucity of data concerning its application in women with deep endometriosis (DE) who are candidates for bowel surgery. The present survey was aimed at gathering detailed information on perioperative management of DE patients undergoing sigmoid/rectal (discoid or segmental) resection within SEGI group. Design: Baseline survey. Setting: National survey conducted within the main Italian cooperative group in minimally invasive gynecologic surgery (SEGI). Patients: The study did not involve patients. Interventions: A 63-item questionnaire, covering ERAS items for g…
Endometrial carcinoma with tibial bone metastasis: a case report and literature review.
2018
Endometrial cancer is the most common female genital malignancy and the seventh most common cause of death from cancer in women in Western countries. The median age of occurrence is 63 years, while...
What is the prognostic importance of lymphovascular space invasion in the absence of lymph node metastasis for early-stage endometrial cancer?
2021
Objective: The aim of this study is to analyze the prognostic role of lymph-vascular space invasion (LVSI), evaluated in a semi-quantitative fashion on prognosis of early stage, low risk endometrial cancer (EC). Methods: We enrolled patients who underwent surgery for endometrial cancer between 2003 and 2018 in two referral cancer center. All patients had endometrioid EC, G1–G2, with myometrial invasion <50%, and no lymph-node involvement. LVSI was analyzed in a semi-quantitative way, according to a 3-tiered scoring system in absent, focal and substantial. Results: Among 524 patients, any positive LVSI was found in 57 patients (10.9%) with focal LVSI (n=35, 6.7%) and substantial LVSI (n=2…
CTLA4-Linked Autoimmunity in the Pathogenesis of Endometriosis and Related Infertility: A Systematic Review
2022
Several studies, although with conflicting results, have sought to determine the concentration of soluble CTLA4 antigens in peripheral blood plasma and peritoneal fluid in patients with endometriosis-related infertility. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) through a search of the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library, Health Technology Assessment Database and Web of Science, and Clinical Trials research register. We included observational or prospective human and animal studies with any features related to endometriosis and/or infertility studies involving CTLA4-rel…
Exploring the feasibility of anti-PD-1/PD-L1 immunotherapy in endometriosis-associated ovarian cancer
2021
La proteina PCNA nel carcinoma dell'endometrio.
2002
Expresión, localización y estudio funcional de PGRMC1 en el endometrio humano a lo largo del ciclo menstrual
2018
Las acciones de la progesterona (P4), en el sistema reproductivo femenino, están principalmente mediadas por los receptores clásicos de la progesterona (PR), que actúan como factores de transcripción. Sin embargo, no todas las acciones fisiológicas de la progesterona pueden explicarse por la activación de dichos receptores. De hecho, se conoce que la progesterona actúa también a través de vías de señalización no clásica más rápidas, mediadas por la activación de receptores de la membrana celular. Entre los receptores no clásicos de la progesterona encontramos PGRMC1 (Progesterone receptor membrane component 1), cuyo mecanismo de acción queda por ser definido. La interacción P4-PGRMC1 media …
Ultramicro-trauma in the endometrial-myometrial junctional zone and pale cell migration in adenomyosis
2015
Objective To determine if ultrastructural tissue trauma occurs in the junctional zone in uteri in adenomyosis. Design A case-control experimental study. Setting Endometriosis research center. Patient(s) Twelve uteri with adenomyosis, and 9 uteri without adenomyosis, were gained during laparoscopy-assisted vaginal hysterectomy. Intervention(s) Transmission electron microscopic study of the junctional zone, as well as immunohistochemical staining for epithelial cadherin, and van Gieson staining and immunofluorescence for CD45 and CD68. Main Outcome Measure(s) Analysis of the electron microscopy photos and the immunoreactive scores of the staining. Result(s) The inner myometrial muscle fibers …