Search results for "EOS"
showing 10 items of 2714 documents
Alzheimer's disease: new diagnostic and therapeutic tools.
2008
Abstract On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lectures of M. Racchi on History and future perspectives of Alzheimer Biomarkers and of G. Scapagnini on Cellular Stress Response and Brain Ageing are summarized. Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease, which in Western society mainly accounts for clinica dementia. AD prevention is an important goal of ongoing research. Two objectives must be accomplished to make prevention feasible: i) individuals at high risk of AD need to be identified before the earliest symptoms become evident, by which time extensive neurodege…
Neural Stem Cells in the Adult Brain: From Benchside to Clinic
2012
Increasing evidence indicates that neural stem cells (NSCs) play an important role in sustaining cellular homeostasis and brain tissue restoration. The study of all mechanisms that control and modulate the function of NSC is a crucial step for the design of therapies against chronic neurodegenerative processes. In this special issue of the journal, we had the pleasure to edit the topic entitled “Neural Stem Cells in the Adult Brain: From Benchside to Clinic.” This special compilation of paper was aimed to provide a global forum for publications of original peer-reviewed manuscripts that reported original research findings in the field of adult neural stem cell, including short communication…
Coleccionismo de arte, museos y procesos de legitimación artística. Estudio de caso del Museo Lladró.
2015
El artículo estudia el caso de la creación de la colección pictórica de la empresa de producción de cerámica Lladró. Se investiga la relación que se establece entre la elección de estas obras y el período cronológico que abarcan. Explicamos la relación entre la pintura valenciana y las piezas de porcelana comercializadas por la empresa. Analizamos cómo la práctica coleccionista de la empresa responde a una estrategia de posicionamiento jerárquico de sus productos, para que sean identificados y valorados como obras de arte y no como objetos industriales, decorativos o kitsch. Todo ello facilita el análisis de las formas de funcionamiento de la cultura visual contemporánea y sus relaciones co…
Use of low dose of rFVIIa (recombinant Factor VII activated) to control late bleeding after percutaneous dilational tracheostomy
2019
Key Clinical Message In our case, the use of a low intravenous bolus dose of rFVIIa (recombinant factor VII activated; 15‐20 mcg/kg) was effective and uneventful in controlling late postprocedural PDT bleeding associated with thrombocytopenia that cannot be corrected and after all other treatments failed.
Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues
2019
Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAM…
From Overstoichiometric to Substoichiometric Enantioselective Protonation with 2-Sulfinyl Alcohols: A View in Perspective
2005
A general study of the enantioselective protonation of prochiral enolates with 2-sulfinyl alcohols is reported. The modification of reaction conditions to reduce drastically the amount of chiral proton source needed to obtain a good enantiomeric excess is reported. The effects of the different factors controlling the stereoselectivity are clearly established. Different protocols for enolate generation are compared.
Biodiversity of Antarctic echinoids: a comprehensive and interactive database
2005
Eighty-one echinoid species are present south of the Antarctic Convergence, and they represent an important component of the benthic fauna. “Antarctic echinoids” is an interactive database synthesising the results of more than 100 years of Antarctic expeditions, and comprising information about all echinoid species. It includes illustrated keys for determination of the species, and information about their morphology and ecology (text, illustrations and glossary) and their distribution (maps and histograms of bathymetrical distribution); the sources of the information (bibliography, collections and expeditions) are also provided. All these data (taxonomic, morphologic, geographic, bathymetri…
Implementation of the Comprehensive Approach. Leadership factors that influence the respect of Human Rights and Humanitarian Law
2020
The respect of Human Rights and International Humanitarian Law is linked to conflict resolution and recent experiences show that is not possible to prevent, manage or resolve a conflict only with military means, a Comprehensive Approach is essential and in this context leadership assumes a crucial role. The purpose of this study is to determine the leadership factors influencing the respect of Human Rights and International Humanitarian Law. The first research question focuses on the relevance of the Comprehensive Approach, while the remaining questions examine why it is so difficult to implement it and how its implementation could improve the respect for Human Rights and the cooperation be…