Search results for "EOs"

Fluorine-containing functionalized cyclopentene scaffolds through ring contraction and deoxofluorination of various substituted cyclohexenes

2018

The fluorination of some highly‐functionalized cyclopentene derivatives, obtained from various substituted cyclohexenes through a ring‐opening/ring‐contraction procedure, has been investigated. The transformations were found to be highly substrate dependent, and led to the formation of various functionalized alicyclic compounds or heterocycles containing allyl difluoride or vinyl fluoride moieties. peerReviewed

PROLONGED TREATMENT OF HUMAN OSTEOSARCOMA MG63 CELLS WITH 3AB INDUCES THE PRODUCTION OF TUMOR INITIATING CELLS.

2008

3AB-OS, a human osteosarcoma stem-like cell line, potential model for studying cancer

2012

In human osteosarcoma 3AB-OS cancer stem cells let-7d seems to have the dual function of oncogene/tumor-suppressor miRNA

2015

Introduction: Osteosarcoma (OS), an aggressive tumor a!ecting adolescents, shows therapy resistance and recurrence which can depend on cancer stem cells (CSCs), the source for tissue renewal and hold malignant potential; thus, OS treatment requires their eradication. Here, using 3AB-OS CSCs previously obtained from the OS-MG63 cells, we focused on the role of let-7d in managing stemness properties of 3AB-OS CSCs. Methods: 3AB-OS CSCs were stably transfected with pCDomH-plasmid, containing mir-let7-d, or empty vector as a control. Cell proliferation and viability were evaluated by EdU and Trypan blue assays, respectively. Sarcosphere and colony assays and wound healing and transwell invasion…

WIN-induced vesiculation cooperates to the inhibition of osteosarcoma cell migration

2015

Introduction. Animal cells release vesicles that mediate the secretion of a variety of factors in the surrounding environment affecting neighboring cells. There is increasing evidence that secreted vesicles play an important role as vehicle of intercellular communication in different biological systems and are able to influence both physiological and pathological processes. Recently, we have reported that the synthetic cannabinoid WIN55,512 is able to induce osteosarcoma MG63 cell death and negatively affect cell migration. Here, we study the effects of WIN on the induction of vesicle secretion and their possible role in WIN-dependent reduction of osteosarcoma cell migratory ability. Method…

Osteosarcoma en la infancia y adolescencia: factores pronósticos e identificación de nuevas dianas terapéuticas

2017

Introduction Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Current management of high-grade osteosarcoma consists of administration of neoadjuvant/adjuvant chemotherapy and complete surgical removal of all tumour sites. The most important prognostic factors for long-term survival are: disease extension (localized/metastatic), primary tumour location (extremity/axial), histologic response to first-line induction chemotherapy and surgical removal of all detectable lesions. The addition of chemotherapy to surgery in the 1970s and 80s increased substantially long-term survival of osteosarcoma patients. However, no further improvement of survival has …

Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging

2013

Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…

Subaerālās atsegšanās notikumu pazīmes un veidojumi devona slāņkopā Latvijā

2015

Promocijas darba mērķis ir identificēt subaerālās atsegšanās notikumus devona periodā Latvijas teritorijā un noskaidrot ģeoloģiskos apstākļus un procesus, kas bija raksturīgi šiem notikumiem. Detalizēti pētīti Živetas stāva Burtnieku svītas, Franas stāva Amatas svītas un Famenas stāva Šķerveļa svītas Nīkrāces ridas nogulumi. Pētījuma pamatā ir dolokrētu paveidu nodalīšana un veidošanās apstākļu interpretācija, pamatojoties uz to struktūru un tekstūru, minerālā sastāva, it īpaši māla minerālu pētījumiem, ģeoķīmisko, t. sk. O un C stabilo izotopu analīzi, kā arī pētījumiem SEM. Ir diskutēts par abiogēnu morfoloģisko pazīmju izmantošanu subaerālās atsegšanās apstākļu identifikācijā, par pētīto…

STATBOX Concept for Simulation of Urban Phenomena

2013

Abstract An urban environment is a dynamic system which is constantly changing in terms of space and time. There are two dimensions in any urban environment – the physical dimension and the functional dimension. All of the structures of an urban environment interact and people are the intermediaries in this process. The spatial structure of cities has been studied from various perspectives by architects, urban planners, environmental scientists, economists, geographers etc. Constant monitoring that is based on remote sensing, spatial statistics, simulation etc., is needed to make on going note of transformation in the various types of land use that exist, movement of people and business env…

Estudio de la suplementación de la dieta materna con cerveza sin alcohol, su efecto sobre el metabolismo oxidativo materno infantil y sobre las propi…

2015

INTRODUCCION: Tras el nacimiento, el ser humano necesita el aporte de antioxidantes que le ayuden a hacer frente al daño oxidativo. La leche humana es la fuente esencial de antioxidantes para el recién nacido pero su composición varía con el estado nutricional y la dieta maternos. Se ha observado que el contenido en antioxidantes y la capacidad antioxidante total de la leche humana, son mayores en el calostro y menores en la leche segregada por la madre en los días y meses posteriores. Es posible que esto sea el resultado del agotamiento de las reservas maternas, como consecuencia de un aumento de demanda, tras el parto y/o de una inadecuada reposición. La cerveza sin alcohol, inocua para e…