Search results for "EPA"
showing 10 items of 8995 documents
Cationic solid lipid nanoparticles complexed with genetic material for liver tumor treatment
2015
Concept Gene therapy is a growing field of medicine with great potential for the treatment of several diseases and it is based on the delivery of nucleic acids (DNA, RNA, etc.,) to specific cells. To achieve their therapeutic effects, the nucleic acids need to cross several biological barriers and be protected from the degradation by nucleases, present in biological fluids and intracellular compartments, to successfully gain access to their intracellular targets. To overcome these hurdles, it is necessary to deliver the genetic material with biocompatible carriers able to facilitate its translocation across the cell membranes and protect it from being degraded while circulating in the blood…
La viabilidad de las pensiones en una economía global en crisis
2015
La tesis pretende estudiar la situación de los sistemas de pensiones desde un punto de vista global y comparativo. Para ello hace un estudio histórico, social, económico y sobre todo jurídico de los principales países europeos y de latinoamericanos. Se analiza asimismo el papel de determinadas entidades en materia de pensiones como el FMI, el Banco Mundial o la Troika, el funcionamiento del mercado laboral en distintos países y el papel de las pensiones complementarias en sus distintos ámbitos.
Regulación de la tasa de mutación en virus de DNA
2019
Los virus de DNA son extremadamente abundantes en todos los ecosistemas pero tradicionalmente se ha pensado que su grado de diversidad genética y adaptabilidad es mucho menor que el de los virus de RNA al presentar tasas de mutación inferiores. La tasa de mutación de algunos virus de DNA puede llegar a ser mil veces superior que la de su hospedador, incluso cuando el virus utiliza la polimerasa de la célula huésped para la replicación. A pesar de ello, existe muy poca información sobre las tasas de mutación de los virus de DNA. Es muy probable que una de las razones sea que las tecnologías de secuenciación de nueva generación (NGS), en muchos casos, presentan tasas de error que son órdenes …
Developments in the biomechanics and equipment of Olympic cross-country skiers
2018
Source at: http://doi.org/10.3389/fphys.2018.00976 Here, our aim was to describe the major changes in cross-country (XC) skiing in recent decades, as well as potential future developments. XC skiing has been an Olympic event since the very first Winter Games in Chamonix, France, in 1924. Over the past decades, considerable developments in skiing techniques and improvements in equipment and track preparation have increased skiing speed. In contrast to the numerous investigations on the physiological determinants of successful performance, key biomechanical factors have been less explored. Today’s XC skier must master a wide range of speeds, terrains, and race distances and formats (e.g., dis…
Iepakojums un tā ietekme uz pircēju rīcību.
2020
Bakalaura darba mērķis ir pamatojoties uz iepakojuma ietekmes teoriju un pircēja rīcību teorijas analīzi un kvalitatīvo un kvantitatīvo metožu pētījumiem, noskaidrot produkta iepakojuma nozīmi pircēju izvēlē, atklāt nepilnības un sniegt priekšlikumus. Darbs sastāv no trim nodaļām. Pirmajā nodaļā tiek aprakstīti iepakojuma teorētiskais raksturojums - iepakojuma funkcijas, dizaina elementi un ietekmes raksturojumi. Otrā nodaļa ietver pircēju rīcības analīzi un tiek aprakstīts izvēles veikšanas modelis un faktori, kas to ietekmē. Trešajā nodaļa tiek aprakstīti anketas un fokusgrupas iegūtie rezultāti. Darbs sastāv no 69 lapas 32 attēliem, 6 tabulām, 9 pielikumiem. Rezultāti norāda kā pircēji u…
Choosing the Right Medium for Municipal eParticipation Based on Stakeholder Expectations
2012
Published version of a chapter in the book: Electronic Participation. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-33250-0_3 This paper examines the expectations and communication needs of relevant stakeholder groups for municipal eParticipation in a small Norwegian municipality. We identified relevant stakeholder groups with the municipality, and asked them about their communication preferences through a combined Delphi study and survey approach. The findings show that information about local issues, information about issues relevant for the individual stakeholder, and dialogue on business’ needs and employment are the three most important communication needs. …
Connecting others: Does a tertius iungens orientation shape the relationship between research networks and innovation?
2021
Research on social networks and innovation emphasizes that individuals spanning structural holes and crossing institutional boundaries have more opportunities for knowledge recombination and innovation involvement. However, transforming the potential knowledge and resources available through personal networks to attain innovation can be difficult for the focal individual. Using an ego-network approach, this study examines whether and to what extent an individual strategic orientation to cooperation (i.e. tertius iungens) contributes to strengthening the relation between two personal network properties (structural and institutional separation) and involvement in innovation. Our analysis is c…
Sabiedrības attieksme pret iepazīšanos internetā: “Tinder” gadījums Latvijas Universitātes studentu vidū
2021
Bakalaura darba tēma ir Sabiedrības attieksme pret iepazīšanos internetā: “Tinder” gadījums Latvijas Universitātes studentu vidū. Bakalaura darba mērķis ir noskaidrot Latvijas Universitātes studentu attieksmi pret iepazīšanos interneta platformā Tinder. Bakalaura darba teorētiskajā daļā tiek aprakstīta sociālās identitātes veidošanās internetā, iepazīšanās internetā psiholoģiskie motīvi un iepazīšanās platformu lietošanas veicinošie un kavējošie faktori. Empīriskajā pētījumā tiek kombinētas kvalitatīvās un kvantitatīvās pētniecības metodes. Lai iegūtu reprezentatīvus datus, kas sniegtu ieskatu par Latvijas Universitātes studentu iepazīšanos internetā psiholoģiskajiem motīviem, kā arī iepazī…
Methods to enhance hydrolysis during one and two-stage anaerobic digestion of energy crops and crop residues
2011
A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A.
2007
A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A. Am J Physiol Gastrointest Liver Physiol 292: G305-G314,2007; doi:10.1152/ajpgi.00100.2006.-Hepatic encephalopathy in patients with liver disease is associated with poor prognosis. This could be due to the induction by the transient episode of hepatic encephalopathy of long-lasting alterations making patients more susceptible. We show that a single transient episode of hyperammonemia induces long-lasting alterations in signal transduction. The content of the regulatory subunit of the protein kinase dependent on cAMP (PKA-RI) is increased in erythrocytes from cirrhotic patients. This increase is…