Search results for "EPHX1"

showing 2 items of 2 documents

Evaluation of the EPHX1 polymorphism on serum levels of 10, 11- eposside carbamazepine

2012

EPHX1
researchProduct

Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients

2014

Antonietta Caruso, Chiara Bellia, Alessia Pivetti, Luisa Agnello, Federica Bazza, Concetta Scazzone, Giulia Bivona, Bruna Lo Sasso, Marcello CiaccioDepartment of Biopathology and Medical and Forensic Biotechnologies, University of Palermo, Palermo, ItalyBackground: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the active metabolite of CBZ) by evaluating the variation in serum CBZ 10,11-epoxide levels 4 hours after administration of the drug. Moreover, we reported the genotype frequencies of …

PharmacologyCYP3A4business.industryCarbamazepineEPHX1Pharmacologydrug metabolismGenotype frequency11-epoxidePharmacogenomics and Personalized MedicineIn vivoGenotypemedicineMolecular MedicineCBZ 10EPHX1 genebusinessActive metaboliteDrug metabolismCYP3A4*22medicine.drugOriginal ResearchPharmacogenomics and Personalized Medicine
researchProduct