Search results for "EPO"

Human, Technologies and Quality of Education: Proceedings of Scientific Papers, 2019

2019

Efectos de los inhibidores de PDE4 en la remodelación celular de modelos in vitro de Fibrosis Pulmonar Idiopática y Enfermedad Pulmonar Obstructiva C…

2018

La enzima PDE4 se ha visto involucrada en las enfermedades crónicas respiratorias. Además, se ha visto que otras enzimas involucradas en inflamación, como la PDE5 en FPI, o en la migración celular y resistencia a corticosteroides, como PI3Kδ en EPOC, ejercen un papel importante en la gravedad y proceso molecular de la enfermedad. Actualmente, roflumilast, un inhibidor de PDE4, ha sido aprobado para el tratamiento de pacientes con EPOC que poseen un historial de exacerbaciones aguadas. El papel de este inhibidor sobre las células involucradas en la FPI y en EPOC severa no ha sido estudiado. Recientemente, se demostrado que la combinación de inhibidores PDE4 y PDE5, disminuye el perfil fibrót…

Selecting the Kth nearest-neighbour for clutter removal in spatial point processes through segmented regression models

2023

We consider the problem of feature detection, in the presence of clutter in spatial point processes. A previous study addresses the issue of the selection of the best nearest neighbour for clutter removal. We outline a simple workflow to automatically estimate the number of nearest neighbours by means of segmented regression models applied to an entropy measure of cluster separation. The method is suitable for a feature with clutter as two superimposed Poisson processes on any twodimensional space, including linear networks. We present simulations to illustrate the method and an application to the problem of seismic fault detection.

Vulvar Epidermal Inclusion Cyst as a Long-term Complication of Female Genital Mutilation

2016

We present a case report of a patient with epidermal inclusion cyst as a late complication of female genital mutilation (FGM). We describe the management of the patient, and a review of the literature. We report the clinical and pathological findings in a 37-year-old female patient from Nigeria, with a clitoral mass of 1 year duration. She declared to have an FGM since she was 5 years. The lesion was excised successfully with good cosmetic results. Histological examination revealed epidermal cyst with the presence of granular layer. An epidermal inclusion cyst can develop as a long-term consequence of FGM.

An anatomical fetal brain structure and a normal variant mimicking anomalies on routine neurosonographic imaging: report of two cases

2004

We present two cases in which an anatomical structure, the calcar avis, and a normal variant, a bifid choroid plexus, mimicked abnormalities on routine prenatal ultrasound examination. To the best of our knowledge these pitfalls have only been described in neonates. A familiarity with these false images is important to avoid erroneous diagnoses.

Non-immune hydrops fetalis: Two case reports

2021

BACKGROUND Fetal hydrops is a serious condition difficult to manage, often with a poor prognosis, and it is characterized by the collection of fluid in the extravascular compartments. Before 1968, the most frequent cause was the maternal-fetal Rh incompatibility. Today, 90% of the cases are non-immune hydrops fetalis. Multiple fetal anatomic and functional disorders can cause non-immune hydrops fetalis and the pathogenesis is incompletely understood. Etiology varies from viral infections to heart disease, chromosomal abnormalities, hematological and autoimmune causes. CASE SUMMARY A 38-year-old pregnant woman has neck lymphoadenomegaly, fever, cough, tonsillar plaques at 14 wk of amenorrhea…

An analysis of interface delamination mechanisms in orthotropic and hybrid fiber-metal composite laminates

2007

Abstract The onset and propagation of interlaminar defects is one of the main damage mechanisms in composite materials. This is even more the case when considering layered materials comprising metallic laminae (typically Aluminium) and FRP laminae. Propagation of delamination mainly depends on the initial crack extension and its loading mode. This work presents some results of a combined analytical–numerical–experimental study on the onset and propagation mechanisms regarding interlaminar defects. Two cases have been analysed in particular, the first consisting of a glass-fibre reinforced epoxy resin laminate, and the second consisting of a hybrid laminate where a lamina of aluminium is lay…

Contribution to the development of 100% bio-based composites : synthesis of bio-based polyepoxides, supercritical CO2 treatment of hemp fibers and im…

2018

This thesis contributes to the development of 100% bio-based hemp/epoxy composites. Current environmental issues favor the emergence of materials derived from renewable resources such as plant fibres and a wide range of bio-based building-blocks, source of epoxy prepolymers in particular. An intensive investigation of the two constituents (hemp fibres and polyepoxidic matrix) is carried out before the composites manufacturing. Supercritical CO2 treatment is applied to hemp fibres used as reinforcement in composite materials. This treatment, not optimized, leads to better individualization as well as a decrease in the hygroscopic power of the fibres. These aspects, which are essential in ord…

Mechanical testing and numerical modelling of pull-wound carbon-epoxy spinnaker poles

2002

The paper deals with experimental testing and numerical simulation of the mechanical behaviour of multi-layer cylindrical coupons, of two different diameters, made in carbon-epoxy composite. The aim of the study is to provide a simple and effective numerical model that can be used as a design tool for structural elements having analogous geometrical and manufacturing characteristics. The numerical analysis, performed in the elastic regime with a standard finite element (FE) code, was strongly correlated with the laboratory determination of fibre-volume fractions and of some elastic parameters of the material system. Other parameters, like the shear modulus values G, were in fact appropriate…

Direct lookup and hash-based metadata placement for local file systems

2013

New challenges to file systems' metadata performance are imposed by the continuously growing number of files existing in file systems. The total amount of metadata can become too big to be cached, potentially leading to multiple storage device accesses for a single metadata lookup operation. This paper takes a look at the limitations of traditional file system designs and discusses an alternative metadata handling approach, using hash-based concepts already established for metadata and data placement in distributed storage systems. Furthermore, a POSIX compliant prototype implementation based on these concepts is introduced and benchmarked. A variety of file system metadata and data operati…