Search results for "EPO"
showing 10 items of 6062 documents
A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis
2021
Adult organisms must sense and adapt to environmental fluctuations. In high-turnover tissues such as the intestine, these adaptive responses require rapid changes in gene expression that, in turn, likely involve posttranscriptional gene control. However, intestinal-tissue-specific microRNA (miRNA)-mediated regulatory pathways remain unexplored. Here, we report the role of an intestinal-specific miRNA, miR-958, that non-cell autonomously regulates stem cell numbers during tissue homeostasis and regeneration in the Drosophila adult midgut. We identify its downstream target cabut, the Drosophila ortholog of mammalian KLF10/11 transcription factors, which mediates this miR-958 function by promo…
Boosting the methanolysis of polycarbonate by the synergy between ultrasound irradiation and task specific ionic liquids
2021
In an attempt to perform polycarbonate chemical recycling in a more sustainable way, we took into consideration the combined use of ultrasound irradiation and task specific ionic liquids. Towards this aim, the methanolysis of polycarbonate, into dimethylcarbonate and bisphenol A, was carried out in the presence of cholinium-based ionic liquids featuring anions derived from amino acids and other eco-friendly species. The target process was optimized in terms of both energy and material amounts as well as in terms of the nature of the catalysts used. The proposed protocol allowed high conversion and yields of bisphenol A to be obtained, under milder conditions compared to the ones so far repo…
Cluster Preface: Heterogeneous Catalysis
2016
International audience; Jean-Cyrille Hierso is full professor of Chemistry since 2009, heading the group of ‘Organometallic Chemistry and Catalysis’ at the Institute of Molecular Chemistry at the University of Bourgogne Franche-Comté (UBFC). He has interest in the fields of organometallic chemistry, ligand design, homo- and heterogeneous catalysis, chemical physics, and material sciences. In 2011 he was awarded the National Prize for Coordination Chemistry from the French Chemical Society (SCF), and at the end of 2012 he was elected a junior Member of the French Professors Academy ‘Institut Universitaire de France’ (IUF).Yasuhiro Uozumi is a full professor at the Institute for Molecular Sci…
Examples of xylochemistry: colorants and polymers
2017
Against the backdrop of modern sustainable chemistry and valorization of biomass for chemical raw materials, the syntheses of indigo dyes and polyamides as representatives of two classes of everyday chemical products based on xylochemicals are described. Wood-derived starting materials were transformed into functional materials using the principles of green chemistry to expand the scope of products gained from renewable resources. The indigo dyes were synthesized in a short, straightforward sequence starting from vanillin. Two polyamides, representatives of an important class of polymers, were obtained from 4-propylcyclohexanol, which is one of the longest known (and most abundant) hydrogen…
Sustainable access to biobased biphenol epoxy resins by electrochemical dehydrogenative dimerization of eugenol
2019
Limited fossil resources require innovative monomers and polymers derived from renewable feedstocks such as plant biomass. Thermosetting epoxy resins largely rely on petrochemical bisphenol-type monomers, which give high performance materials but are controversial due to their effects on human health. Herein, we present two biobased epoxy resins by direct dehydrogenative dimerization of eugenol, the main component of clove oil. Taking the Principles of Green Chemistry into account, we developed electrochemical dehydrodimerization at reticulated vitreous carbon (RVC) electrodes using methanol as environmentally benign solvent. Thus, fluorinated solvents such as 1,1,1,3,3,3-hexafluoroisopropa…
Grupos empresariales y reportes de sostenibilidad en América Latina
2018
En esta investigación abordamos los reportes de sostenibilidad de los grupos empresariales. La mayoría de los informes de sostenibilidad de las principales compañías alrededor del mundo se elaboran siguiendo las recomendaciones establecidas en el Global Reporting Initiative (GRI) (Ernst & Young, 2017; WBCSD, 2017). Por ello, partiendo de los grupos empresariales del sector real incluidos en GRI Reports List para los países que integran la Alianza del Pacífico y a su vez el Mercado Integrado Latinoamericano –MILA -, esto es Chile, Colombia, México y Perú, aportamos evidencia empírica y contextual en torno a las características y consideraciones que motivan la presentación de los reportes de …
El problema de la etnia tártara en la U.R.S.S.
1992
ESTE ES UN ESTUDIO SOBRE LOS PROBLEMAS AFRONTADOS POR LA NACION TARTARA DE LA PENINSULA DE CRIMEA DESDE SU CONQUISTA POR RUSIA EN EL SIGLO XVIII HASTA LA ACTUALIDAD, CON ESPECIAL HINCAPIE EN LAS VICISITUDES SUFRIDAS DESDE LA REVOLUCION DE OCTUBRE DE 1971 -GUERRA CIVIL, HAMBRES- Y EN LA DEPORTACION EN MASA SUFRIDA EN LOS AÑOS CUARENTA POR ORDEN DE STALIN.
Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence.
2013
8-Oxoguanine (8-oxoG) is a major product of oxidative DNA damage, which induces replication errors and interferes with transcription. By varying the position of single 8-oxoG in a functional gene and manipulating the nucleotide sequence surrounding the lesion, we found that the degree of transcriptional inhibition is independent of the distance from the transcription start or the localization within the transcribed or the non-transcribed DNA strand. However, it is strongly dependent on the sequence context and also proportional to cellular expression of 8-oxoguanine DNA glycosylase (OGG1)-demonstrating that transcriptional arrest does not take place at unrepaired 8-oxoG and proving a causal…
8-Oxoguanine DNA glycosylase (Ogg1) causes a transcriptional inactivation of damaged DNA in the absence of functional Cockayne syndrome B (Csb) prote…
2008
We have analysed the effect of oxidative guanine lesions on the expression of a transfected reporter gene in mouse embryonic fibroblasts deficient in Cockayne syndrome B protein (Csb) and/or the 8-oxoguanine DNA glycosylase (Ogg1). We used a highly sensitive flow cytometry-based approach and quantitative real-time PCR to measure the changes in gene expression caused by the presence of oxidised guanine residues generated by photosensitisation in the vector DNA. In wild-type cells, small numbers (one or three) of oxidised guanines did not affect gene expression at short times after transfections, whereas progressive reduction of the transgene expression was observed at later time points. Alth…
La Grande Guerra racconta sul giornale "L'Ora"
2020
Il saggio propone alcuni momenti ed episodi del primo anno di guerra, attraverso una piccola campionatura di articoli pubblicati sul quotidiano "L’Ora" di Palermo. riguardanti il 1915. Allo scoppio della prima guerra mondiale il quotidiano fondato da Ignazio Florio è al suo quattordicesimo anno di vita ed è sotto la direzione di Francesco Paolo Mulè. Dallo spoglio effettuato emerge che, accanto alla divulgazione dei resoconti ufficiali giunti da Roma, con il quasi quotidiano accompagnamento dei comunicati del Generale Cadorna dal fronte, vengo- no pubblicate corrispondenze di guerra mutuate dal Corriere della sera e del Mattino. Ci si sofferma in particolare su alcuni reportage di Luigi …