Search results for "EPOC"
showing 10 items of 62 documents
LA SFIDA DELL'EDUCATIVO NELLA SOCIETA' LIQUIDA
2014
Le società della tarda modernità sono segnate da un deficit di educazione. L'alternativa ad una società liquida non è tanto una società solida, ma una società autentica, segnata da una ricerca del senso originario dell'educare e che assume il tempo presente, anche le sue problematicità e le incertezze, come terreno propizio per una rinnovata esistenza morale.
Jutekliskās uztveres tematizācija Pētera Handkes stāstā „Senviktuāras kalna mācība”
2015
Bakalaura darbs ir veltīts tēmai „Jutekliskās uztveres tematizācija Pētera Handkes stāstā Senviktuāra kalna mācība”. Darba mērķis ir izmeklēt un aplūkot Pētera Handkes jutekliskās uztveres atspoguļojumu stāstā Senviktuāra kalna mācība. Darba uzdevums ir izpētīt rakstnieka Pētera Handkes personību un viņa slaveno tetraloģiju, it īpaši tetraloģijas otro daļu. Darbs ir sadalīts trijās nodaļās. Pirmajā nodaļā tiek apskatīts un visparēji raksturots jēdziens „mūsdienu literatūra”, kā arī tiek apskatīta tā laika politiskā un sabiedriskā situācija Vācijā un Austrijā. Papildus tiek apskatīta mūsdienu rakstnieku paaudze un Pēters Handke tiek prezentēts kā mūsdienu vācu rakstnieku paaudzes populārs pā…
Efectos de los inhibidores de PDE4 en la remodelación celular de modelos in vitro de Fibrosis Pulmonar Idiopática y Enfermedad Pulmonar Obstructiva C…
2018
La enzima PDE4 se ha visto involucrada en las enfermedades crónicas respiratorias. Además, se ha visto que otras enzimas involucradas en inflamación, como la PDE5 en FPI, o en la migración celular y resistencia a corticosteroides, como PI3Kδ en EPOC, ejercen un papel importante en la gravedad y proceso molecular de la enfermedad. Actualmente, roflumilast, un inhibidor de PDE4, ha sido aprobado para el tratamiento de pacientes con EPOC que poseen un historial de exacerbaciones aguadas. El papel de este inhibidor sobre las células involucradas en la FPI y en EPOC severa no ha sido estudiado. Recientemente, se demostrado que la combinación de inhibidores PDE4 y PDE5, disminuye el perfil fibrót…
Estimulantes y Activadores de la Guanilato Ciclasa en el Tratamiento del Asma y la Enfermedad Pulmonar Obstructiva Crónica
2022
La enzima guanilato ciclasa soluble (GCs) tras la unión del óxido nítrico (NO), cataliza la conversión del guanosín 5′-trifosfato (GTP) en guanosín 3,5-monofosfato cíclico (GMPc), un segundo mensajero que participa en diversos procesos fisiológicos entre los que se incluyen la relajación muscular, la dilatación de los bronquios y de los vasos sanguíneos, efectos en las rutas de señalización de diferenciación y proliferación celular, efectos antiinflamatorios e inhibición de la agregación de plaquetas. En las vías aéreas de los pacientes con Enfermedad Pulmonar Obstructiva Crónica (EPOC) y asma, dos enfermedades respiratorias caracterizadas por una inflamación crónica y una obstrucción de la…
LKS-92 Coordinates Transformation to ITRF2000
2014
LKS-92 is Latvian geodetic coordinate system used as an EUREF89 realization in Latvia. LKS-92 is official coordinate system for procuring of essential geospatial data. For aeronautical and other purposes ITRF2000 is used in publication of geospatial data. Research is done to obtain transformation parameters from LKS-92 realization epoch 1992.75 through LatPos to ITRF2000 epoch 2000.00. Valuation of two different coordinate adjustment strategies and accuracy of parameters is done. Results of research could be used for transformation from LKS-92 to ITRF2000 for all kind of geospatial data.
Is the Anthropocene really worthy of a formal geologic definition?
2014
Scientists are actively debating whether the Anthropocene, the geologic time span (GTS) we are now living in, should be considered a period, epoch, or age in the geologic timescale. The solution is not easy, because the beginning of this GTS is undefined and the end unknown. In fact, there is no agreement on when the Anthropocene began, the proposed dates ranging from the Second World War, when radioactive fallout branded soils and sediments all over the world, to little after the end of the last glacial period, i.e. 11.7 thousand years ago, therefore coinciding with the onset of the Holocene. We are in favour of a concurrence of the Anthropocene with the Holocene, although a major impact …
Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases.
2021
Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death.A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease. Evaluation of factors associated with survival and secondary composite end-point such as ICU admission and respiratory support, were explored.1,271 patients (22%) had a previous lung disease, mostly COPD. All-cause mortality occurred in 376 patients with lung disease (29.5%) and in 819 patients without (17.9%) (Previous lung disease is a risk factor for mortality in patients with COVID-19.…
ORIGIN: metal creation and evolution from the cosmic dawn
2012
Herder, Jan-Willem den et al.
Correction: Phylogeny of the Eurasian Wren Nannus troglodytes (Aves: Passeriformes: Troglodytidae) reveals deep and complex diversification patterns …
2020
The Mediterranean Basin represents a Global Biodiversity Hotspot where many organisms show high inter- and intraspecific differentiation. Extant phylogeographic patterns of terrestrial circum-Mediterranean faunas were mainly shaped through Pleistocene range shifts and range fragmentations due to retreat into different glacial refugia. Thus, several extant Mediterranean bird species have diversified by surviving glaciations in different hospitable refugia and subsequently expanded their distribution ranges during the Holocene. Such a scenario was also suggested for the Eurasian Wren (Nannus troglodytes) despite the lack of genetic data for most Mediterranean subspecies. Our phylogenetic mult…
Detection of a large Be circumstellar disk during X-ray quiescence of XTE J1946+274
2014
We present a multiwavelength study of the Be/X-ray binary system XTE J1946+274 with the main goal of better characterizing its behavior during X-ray quiescence. We aim to shed light on the mechanism which triggers the X-ray activity for this source. XTE J1946+274 was observed by Chandra-ACIS during quiescence in 2013 March 12. In addition, this source has been monitored from the ground-based astronomical observatories of El Teide (Tenerife, Spain), Roque de los Muchachos (La Palma, Spain) and Sierra Nevada (Granada, Spain) since 2011 September, and from the TUBITAK National Observatory (Antalya, Turkey) since 2005 April. We have performed spectral and photometric temporal analyses in order …