Search results for "EPOR"
showing 10 items of 2839 documents
Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: neural expression is mediated by GATA factor bindin…
1999
The SCL gene encodes a basic helix-loop-helix transcription factor with a pivotal role in the development of endothelium and of all hematopoietic lineages. SCL is also expressed in the central nervous system, although its expression pattern has not been examined in detail and its function in neural development is unknown. In this article we present the first analysis of SCL transcriptional regulation in vivo. We have identified three spatially distinct regulatory modules, each of which was both necessary and sufficient to direct reporter gene expression in vivo to three different regions within the normal SCL expression domain, namely, developing endothelium, midbrain, and hindbrain/spinal …
Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells
2001
Enhancers located in the 3' end of the locus in part regulate immunoglobulin heavy chain (IgH) gene expression. One of these enhancers, HS 1,2, is developmentally regulated by DNA binding proteins like NF-kappaB, Pax-5 and the protein complex NF-alphaP in B lineage cells. Here we report that NF-alphaP is the ets protein PU.1. A glutathione-S-transferase (GST)-pulldown assay demonstrated that PU.1 can physically interact with NF-kappaB in solution. Experiments in COS cells showed that PU.1 and NF-kappaB (p50/c-Rel) can activate transcription of an enhancer linked reporter gene. The paired domain protein Pax-5 has previously been shown to repress enhancer-dependent transcription. Additional c…
Effect of Cry Toxins on Xylotrechus arvicola (Coleoptera: Cerambycidae) Larvae
2022
Simple Summary Xylotrechus arvicola is a destructive pest in vineyards (Vitis vinifera) in the main wine-producing areas of the Iberian Peninsula. X. arvicola larvae bore into the grapevine wood-making galleries, thus damaging the plant both directly and indirectly. The susceptibility of X. arvicola larvae to five coleopteran toxic Cry proteins was evaluated under laboratory conditions in order to deepen the knowledge of the effect of these proteins on this insect throughout its biological development. The Cry proteins tested could be applied to control X. arvicola larvae since they were able to kill them and cause serious alterations in the larvae during the remaining months of development…
Functional characterization of the enhancer blocking element of the sea urchin early histone gene cluster reveals insulator properties and three esse…
2000
Insulator elements can be functionally identified by their ability to shield promoters from regulators in a position-dependent manner or their ability to protect adjacent transgenes from position effects. We have previously reported the identification of a 265 bp sns DNA fragment at the 3' end of the sea urchin H2A early histone gene that blocked expression of a reporter gene in transgenic embryos when placed between the enhancer and the promoter. Here we show that sns interferes with enhancer-promoter interaction in a directional manner. When sns is placed between the H2A modulator and the inducible tet operator, the modulator is barred from interaction with the basal promoter. However, th…
Integrated reporting: a new approach or a change of label?
2014
The aim of this paper is to provide insights into the early stage development of integrated reporting (IR). In particular, its purpose is to investigate whether it might represent a real new mode of corporate reporting or just a way to strengthen other financial and sustainability reports. The paper argues that connectivity of information is crucial to this distinction. Based on previous studies on corporate disclosure and on new research perspectives on IR, this paper shows the preliminary findings of a content analysis of the reports of a selected sample of companies. The first results that should be further researched highlight that more efforts need to be taken to shift IR from the trad…
Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor
2020
The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the thr…
Tema 7.2. Entrenament psicològic
2019
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València Tema 7.2 de l'assignatura Entrenament de la Tècnica i la Tàctica del Grau en Ciències de l'Activitat Física i l'Esport
Family networks and refugees’ health conditions. A picture from Italian informal settlements
2021
While the relationships between social networks and health are widely acknowledged in the literature, few of these studies have covered the population of refugees living in makeshift camps. In our analysis of a nationally representative Italian survey of individuals living in informal settlements, we find that many had weak family relations: only 10 per cent had one or more family members in their settlement. The paper analyses the effects of individual social network on two measures of health, and finds that the refugees’ health conditions were associated with both their personal characteristics and the characteristics of the settlement. The results show that more than 50 per cent of these…
Costs and benefits of reporting Key Audit Matters in the audit reports
2014
International audience
Autoconcepto y deporte extraescolar en preadolescentes valencianos
2011
1.Introducción Numerosos estudios han evidenciado que la práctica deportiva además de los beneficios físicos proporciona una mejora en el desarrollo del autoconcepto tanto físico como general (Goñi, Ruiz de Azua y Rodríguez,2004 y Moreno y Cervelló, 2005) y el desarrollo de conductas más saludables (Balaguer y García-Merita, 1994; Pastor, Balaguer y García Merita, 2008; Goñi y Rodríguez, 2004, 2007; Contreras, Gil, Fernández y Pastor, 2010). Se define el autoconcepto como "una construcción cognitiva, al mismo tiempo que social, que se desarrolla a lo largo de la vida formada por el conjunto de características asumidas de manera consciente por el individuo" (Harter, 1999). El autoconcepto se…