Search results for "EPOR"

Señor. En Real Orden de 16. de Febrero de este año, que se me entregò el dia 28. de Março de el mismo à las 8 de la mañana, se sirviò V.M. man…

1735

Cristus i caplletra grav. a la p. 1 Sign.: A-I2, K3 Reclams

Señor. En Real Orden de 16. de Febrero de este año, que se me entregò el dia 28. de Março de el mismo à las 8 de la mañana, se sirviò V.M. mandarme s…

L'autor de la carta a Felip V és Blas Jover Alcázar, segon es despren del text a la p. 17 i el motiu: la seua deportació, atribuïda a l'enemistat del Marquès del Risco Sense port. ni colofó, com a tít. el començament del text Cristus i caplletra grav. a la p. 1 Sign.: A-I2, K3 Reclams

Señor. D. Blas Jover Alcazar, ministro criminal de Valencia ... expone las justas legales sospechas que tiene del Marquès del Risco, assi antecedente…

Cristus al f. 1 Sign.: [ ]1, A-P2, P-X2 Reclams

El deporte como medio de inserción social de los jóvenes de barrios desfavorecidos

2009

En este artículo realizamos una síntesis de la tesis doctoral �Inserción Juvenil y Actividad Física: una forma de intervención en el contexto de los barrios desfavorecidos� cuyo objetivo ha consistido en analizar el papel del deporte con colectivos socialmente desfavorecidos, en concreto con los jóvenes de barrios marginales. Con este fin hemos estructurado el texto en tres apartados: en primer lugar, presentamos los argumentos teóricos que sustentan la idea del deporte-inserción; en segundo lugar, detallamos los aspectos metodológicos que han guiado la investigación; y, por último, dedicamos un apartado al estudio de caso y las consideraciones finales.

Regulation of X Chromosome-Linked Inhibitor of Apoptosis Protein (XIAP) in Kainic Acid Induced Neuronal Cell Death in the Rat Hippocampus

2001

INTRODUCTION. Inhibitor of apoptosis protein (IAP) family consists of several antiapoptotic proteins conserved among species. The IAPs have a well-conserved motif of approximately 65 residues, called the baculovirus inhibitory repeat (BIR) (1). Baculovirus and drosophila IAPs have two, but most IAPs contain three BIR domains. Most of the IAPs also have a C-terminal RING domain which consists of conserved amino acids with zinc binding capacity. XIAP is one of the five known human IAPs and it binds directly and inhibits the activity of caspases (2). The BIR2 domain in XIAP is sufficient to mediate this inhibition (3). However little is known about the presence and function of XIAP in the nerv…

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

2018

The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the inducti…

Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma

2020

Metastasis to the oral cavity are rare, representing only 1% of all oral malignancies, and originate from various sites such as the breast, prostate, lung and kidney. Clinically, they can simulate reactive and inflammatory lesions common in the oral cavity, and the clinical and microscopic diagnosis of these metastasis is a challenge. In this article, we report two new cases of esophageal and lung metastasis to oral tissues, highlighting their clinical characteristics and the process of diagnostic elucidation. We emphasize the importance for clinicians to consider the possibility of metastatic lesions in the oral cavity in patients previously diagnosed with malignant lesions in distant tiss…

Effects of whole-body vibration exercise on muscular strength and power, functional mobility and self-reported knee function in middle-aged and older…

2013

Abstract Background Whole-body vibration training using vertical-vibration machines is called “acceleration training” (AT). The purpose of this study was to elucidate the effect of AT on lower-limb muscular strength and power, functional mobility and self-reported knee function in middle-aged and older Japanese women with knee pain. Methods Thirty-eight middle-aged and older Japanese women (aged 50–73 years) with knee pain were divided into two groups: (1) the AT group (n = 29) engaged in AT three times per week for eight weeks, and (2) the control group (C group, n = 9). The AT program consisted of flexibility training, strength training of mainly the quadriceps and surrounding muscles and…

On the use of information systems research methods in data mining

2006

Information systems are powerful instruments for organizational problem solving through formal information processing (Lyytinen, 1987). Data mining (DM) and knowledge discovery are intelligent tools that help to accumulate and process data and make use of it (Fayyad, 1996). Data mining bridges many technical areas, including databases, statistics, machine learning, and human-computer interaction. The set of data mining processes used to extract and verify patterns in data is the core of the knowledge discovery process. Numerous data mining techniques have recently been developed to extract knowledge from large databases. The area of data mining is historically more related to AI (Artificial…

The Common Good Balance Sheet, an Adequate Tool to Capture Non-Financials?

2019

In relation to organizational performance measurement, there is a growing concern about the creation of value for people, society and the environment. The traditional corporate reporting does not adequately satisfy the information needs of stakeholders for assessing an organization&rsquo