Search results for "EPP"
showing 10 items of 427 documents
Spasmolytic Effects of Aphanizomenon Flos Aquae (AFA) Extract on the Human Colon Contractility.
2021
The blue-green algae Aphanizomenon flos aquae (AFA), rich in beneficial nutrients, exerts various beneficial effects, acting in different organs including the gut. Klamin® is an AFA extract particularly rich in β-PEA, a trace-amine considered a neuromodulator in the central nervous system. To date, it is not clear if β-PEA exerts a role in the enteric nervous system. The aims of the present study were to investigate the effects induced by Klamin® on the human distal colon mechanical activity, to analyze the mechanism of action, and to verify a β-PEA involvement. The organ bath technique, RT-PCR, and immunohistochemistry (IHC) were used. Klamin® reduced, in a concentration-dependent manner, …
Numerical solution of a spatio-temporal gender-structured model for hantavirus infection in rodents.
2017
In this article we describe the transmission dynamics of hantavirus in rodents using a spatio-temporal susceptible-exposed-infective-recovered (SEIR) compartmental model that distinguishes between male and female subpopulations [L.J.S. Allen, R.K. McCormack and C.B. Jonsson, Bull. Math. Biol. 68 (2006), 511--524]. Both subpopulations are assumed to differ in their movement with respect to local variations in the densities of their own and the opposite gender group. Three alternative models for the movement of the male individuals are examined. In some cases the movement is not only directed by the gradient of a density (as in the standard diffusive case), but also by a non-local convolution…
Late Aragonian mammal sites of Cuesta del Rey (Duero Basin, Burgos, Spain)
2017
[EN]: The Cuesta del Rey mammal sites located on the NE border of the Duero Basin are of great importance with regard to understand the general biostratigraphy of the basin, because Miocene mammal sites are extremely scarce in this area in comparison with the central part of the basin. The mammals identified in Cuesta del Rey-1 are: Eulipotyphla: cf. Miosorex sp.; Rodentia: Heteroxerus sp., Armantomys cf. tricristatus, Megacricetodon ibericus, Megacricetodon minor-Megacricetodon debruijni, Hispanomys sp. And Democricetodon sp. The Cuesta del Rey-1 rodent assemblage is characteristic of the end of the upper Aragonian (MN 7/8, end of the middle Miocene), equivalent to the local subzone G3 of …
The story of endurance:Biogeography and the evolutionary history of four Holarctic butterflies with different habitat requirements
2021
Aim: Biogeographical studies on the entire ranges of widely distributed species can change our perception of species’ range dynamics. We studied the effects of Pleistocene glacial cycles on current butterfly species distributions, aiming to uncover complex biogeographic patterns in the Holarctic, a region dramatically affected by Cenozoic climate change. Location: Eurasia and North America. Taxon: Boloria chariclea, Agriades optilete, Carterocephalus palaemon, Oeneis jutta. Methods: We reconstructed the biogeographic history of four butterfly species differing in habitat preferences (B. chariclea – tundra, A. optilete – bogs, C. palaemon – temperate grasslands, O. jutta – taiga), using one …
“Mariani, Angelo”
2008
Angelo Mariani fu il primo direttore d'orchestra italiano in senso moderno,ossia il primo a unire in sé le due figura di "primo violino" e "maestro concertatore". La presente voce ricostruisce la sua biografia e ripercorre gli aspetti principali della sua attività direttoriale, a cominciare dal rapporto con Giuseppe Verdi
Late Quaternary environments in the Gobi Desert of Mongolia: Vegetation, hydrological, and palaeoclimate evolution
2019
Abstract Considerable efforts have been devoted to decipher the late Quaternary moisture and thermal evolution of arid central Asia. However, disparate interpretations still exist concerning different proxies. The spatial and temporal heterogeneities have inhibited a holistic understanding of general patterns and underlying mechanisms. To address these issues, two parallel cores (ONW I, 6.00 m; ONW II, 13.35 m) were retrieved in the Gobi Desert of Mongolia from lake Orog Nuur. Multidisciplinary investigations including geomorphological mapping, radiocarbon dating, sedimentological, palynological and ostracod analyses enabled us to gain a comprehensive dataset for vegetation development and …
Cueva Antón: A multi-proxy MIS 3 to MIS 5a paleoenvironmental record for SE Iberia
2016
Overlying a palustrine deposit of unknown age (complex FP), and protected from weathering and erosion inside a large cave/rock-shelter cavity, the sedimentary fill of Cueva Antón, a Middle Paleolithic site in SE Spain, corresponds in most part (sub-complexes AS2-to-AS5) to a ca.3 m-thick Upper Pleistocene terrace of the River Mula. Coupled with the constraints derived from the deposit’s paleoclimatic proxies, OSL dating places the accumulation of this terrace in MIS 5a, and radiocarbon dates from the overlying breccia cum alluvium (sub-complex AS1) fall in the middle part of MIS 3; the intervening hiatus relates to valley incision and attendant erosion. The two intervals represented remain …
PLA-based functionally graded laminates for tunable controlled release of carvacrol obtained by combining electrospinning with solvent casting
2020
Abstract A novel approach was designed to fabricate high-added value manufacts, starting from cost-effective materials and combining well-known processing techniques. Bi- and three-layered, functionally graded laminates were achieved by direct electrospinning onto dense substrates. The architecture of each multilayer comprises a dense layer formed by solvent casting, which is constituted by polylactic acid (PLA) and carvacrol, and one or two electrospun fibrous skin layers, consisting of PLA only. Processing-structure-properties relationships of such materials were investigated. As regards mechanical behavior, the amount of fibrous PLA layers determined an increase of stiffness from 20 to 3…
Conflict resolution in the multi-stakeholder stepped spillway design under uncertainty by machine learning techniques
2021
Abstract The optimal spillway design is of great significance since these structures can reduce erosion downstream of the dams. This study proposes a risk-based optimization framework for a stepped spillway to achieve an economical design scenario with the minimum loss in hydraulic performance. Accordingly, the stepped spillway was simulated in the FLOW-3D® model, and the validated model was repeatedly performed for various geometric states. The results were used to form a Multilayer Perceptron artificial neural network (MLP-ANN) surrogate model. Then, a risk-based optimization model was formed by coupling the MLP-ANN and NSGA-II. The concept of conditional value at risk (CVaR) was utilized…
Approximation-Based Adaptive Fuzzy Tracking Control for a Class of Nonstrict-Feedback Stochastic Nonlinear Time-Delay Systems
2015
This paper focuses on the problem of approximation-based adaptive fuzzy tracking control for a class of stochastic nonlinear time-delay systems with a nonstrict-feedback structure. A variable separation approach is introduced to overcome the design difficulty from the nonstrict-feedback structure. Mamdani-type fuzzy logic systems are utilized to model the unknown nonlinear functions in the process of controller design, and an adaptive fuzzy tracking controller is systematically designed by using a backstepping technique. It is shown that the proposed controller guarantees that all signals in the closed-loop system are fourth-moment semiglobally uniformly ultimately bounded, and the tracking…