Search results for "ERAN"

Host-Derived CD8+ Dendritic Cells Protect Against Acute Graft-versus-Host Disease after Experimental Allogeneic Bone Marrow Transplantation

2014

Graft-versus-host disease (GVHD) is a frequent life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT) and induced by donor-derived T cells that become activated by host antigen-presenting cells. To address the relevance of host dendritic cell (DC) populations in this disease, we used mouse strains deficient in CD11c(+) or CD8α(+) DC populations in a model of acute GVHD where bone marrow and T cells from BALB/c donors were transplanted into C57BL/6 hosts. Surprisingly, a strong increase in GVHD-related mortality was observed in the absence of CD11c(+) cells. Likewise, Batf3-deficient (Batf3(-/-)) mice that lack CD8α(+) DCs also displayed a strongly incr…

Absence of the lactase-persistence-associated allele in early Neolithic Europeans.

2007

Lactase persistence (LP), the dominant Mendelian trait conferring the ability to digest the milk sugar lactose in adults, has risen to high frequency in central and northern Europeans in the last 20,000 years. This trait is likely to have conferred a selective advantage in individuals who consume appreciable amounts of unfermented milk. Some have argued for the “culture-historical hypothesis,” whereby LP alleles were rare until the advent of dairying early in the Neolithic but then rose rapidly in frequency under natural selection. Others favor the “reverse cause hypothesis,” whereby dairying was adopted in populations with preadaptive high LP allele frequencies. Analysis based on the cons…

Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis.

2015

Dendritic cells (DCs) are professional antigen presenting cells that have the dual ability to stimulate immunity and maintain tolerance. However, the signalling pathways mediating tolerogenic DC function in vivo remain largely unknown. The beta-catenin pathway has been suggested to promote a regulatory DC phenotype. The aim of this study was to unravel the role of beta-catenin signalling to control DC function in the autoimmune collagen-induced arthritis model (CIA). Deletion of beta-catenin specifically in DCs was achieved by crossing conditional knockout mice with a CD11c-Cre transgenic mouse line. Bone marrow-derived DCs (BMDCs) were generated and used to study the maturation profile of …

Az ember gitárja : a mindent túlélő hangszer = The guitar of man : a musical instrument surviving everything

2010

Myopathy with hexagonally cross-linked crystalloid inclusions: delineation of a clinico-pathological entity.

2010

A novel myopathy characterized by hexagonally cross-linked tubular arrays has been reported in five patients. We studied the clinical and histopathological features of five additional unrelated patients with this myopathy. Patients experienced exercise intolerance with exercise-induced myalgia and weakness, without rhabdomyolysis. One patient additionally presented mild permanent pelvic girdle muscle weakness. Age at onset varied between 13 and 56 years. The inclusions were eosinophilic on H and E, bright red with modified Gomori’s trichrome stains, present in type 2 fibers, and revealed immunoreactivity selectively for a caveolin-3-antibody. Ultrastructurally, the inclusions showed a highl…

Erityinen ystävyys : miehen ja naisen välinen rakkaus uuden ajan alun Suomessa (n. 1650-1700)

2015

Nenoteiktības nenoturības saistība ar elektrodermālās aktivitātes rādītājiem

2019

Darba mērķis bija noskaidrot, kāda saistība pastāv starp indivīda nenoteiktības nenoturību un elektrodermālo aktivitāti1) noteiktā un nenoteiktā situācijā, 2) neitrālu un negatīvu audiālo stimulu gadījumā, 3) gaidot situācijas iznākumu un pēc tās. Pētījumā piedalījās 25 dalībnieki, ar vidējo vecumu M = 24,62, SD = 4,42 gadi. Tika demonstrēta attēlu un skaņas signālu sērija, paralēli mērot elektrodermālo aktivitāti. Tika izmantota Nenoteiktības nenoturības 12 pantu skalu un DASS-21. Nenoteiktības nenoturības 12 pantu skalas iekšējā saskaņotība bija laba, bet konverģentā validitāte bija vāja. Tika secināts, ka indivīdiem ar augstāku nenoteiktības nenoturību, bija lielāka elektrodermālā aktivi…

Latest Developments and Results of Radiation Tolerance CMOS Sensors with Small Collection Electrodes

2020

The development of radiation hard Depleted Monolithic Active Pixel Sensors (DMAPS) targets the replacement of hybrid pixel detectors to meet radiation hardness requirements of at least 1.5e16 1 MeV neq/cm2 for the HL-LHC and beyond. DMAPS were designed and tested in the TJ180 nm TowerJazz CMOS imaging technology with small electrodes pixel designs. This technology reduces costs and provides granularity of 36.4x36.4 um2 with low power operation (1 uW/pixel), low noise of ENC < 20 e-, a small collection electrode (3 um) and fast signal response within 25 ns bunch crossing. This contribution will present the latest developments after the MALTA and Mini-MALTA sensors. It will illustrate the imp…

Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease

2021

Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32)

'We have a solution': Delivering on the promise to take national responsibility for nuclear waste management

2022

We examine the realization of the umbrella promise to assume national responsibility for the final disposal of spent nuclear fuel. Three case studies are used to illustrate how Finland delivers on the promise to take care of its own nuclear waste - a promise that has greatly contributed to the legitimacy of nuclear power in Finland. The article shows how this promise is being challenged by new competitors, business visionaries, and the public. The case studies illustrate the tensions between those who made the promise and the actors who interpret and mobilize the promise for varying purposes and under changing circumstances. We investigate techno-scientific promises by looking at debates ab…