Search results for "ERAS"

Stereochemical features of the hydrolysis of 9,10-epoxystearic acid catalysed by plant and mammalian epoxide hydrolases

2002

cis-9,10-Epoxystearic acid was used as a tool to probe the active sites of epoxide hydrolases (EHs) of mammalian and plant origin. We have compared the stereochemical features of the hydrolysis of this substrate catalysed by soluble and membrane-bound rat liver EHs, by soluble EH (purified to apparent homogeneity) obtained from maize seedlings or celeriac roots, and by recombinant soybean EH expressed in yeast. Plant EHs were found to differ in their enantioselectivity, i.e. their ability to discriminate between the two enantiomers of 9,10-epoxystearic acid. For example, while the maize enzyme hydrated both enantiomers at the same rate, the EH from soybean exhibited very high enantioselecti…

Vidzemes guberņas pagasttiesas 19.gadsimtā: Valmieras apriņķa pagasttiesas iecirkņu piemērs

2016

Bakalaura darba nosaukums “Vidzemes guberņas pagasttiesas 19. gadsimtā: Valmieras apriņķa pagasttiesas iecirkņu piemērs”. Darbā pētītas Vidzemes guberņas latviešu daļas pagasttiesu funkcijas, pakļautība un to nozīme zemnieku tiesību aizstāvībā un tiesiskās izpratnes veidošanā. Darba gaitā tika secināts, ka 19. gs. gaitā pagasttiesas bija izgājušas zināmu attīstības procesu no sākotnējā, kad to funkcijās bija vērojama būtiska muižas ietekme, līdz laikam, kad tās kļuva par pilntiesīgu tiesu iestādi, kurā zemnieki varēja vērsties pēc tiesiskās aizsardzības. Pagasttiesas ļāva latviešu zemniekiem iegūt pieredzi saskarsmē ar tiesu un citām valsts institūcijām un, radot izpratni par pienākumiem un…

Real-life evaluation of a rapid extraction-free SARS-CoV-2 RT-PCR assay (COVID-19 PCR Fast-L) for the diagnosis of COVID-19.

2021

Repeated Testing in SARS-CoV-2 Infection

2020

Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?

2020

The authors would like to thank Agnieszka Michalczuk for providing us with her artistic vision of SARS-CoV-2.

Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care

2021

Early detection is the first step in the fight against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, an efficient, rapid, selective, specific, and inexpensive SARS-CoV-2 diagnostic method is the need of the hour. The reverse transcription-polymerase chain reaction (RT-PCR) technology is massively utilized to detect infection with SARS-CoV-2. However, scientists continue to strive to create enhanced technology while continually developing nanomaterial-enabled biosensing methods that can provide new methodologies, potentially fulfilling the present demand for rapid and early identification of coronavirus disease 2019 (COVID-19) patients. Our review presents a summar…

Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Bir…

2022

Abstract Background Body mass index (BMI) may not be an optimal predictor of frailty as its constituents, lean and fat mass, may have opposite associations with frailty. Methods A linear mixed model analysis was performed in the Helsinki Birth Cohort Study (n = 2 000) spanning from 57 to 84 years. A 39-item frailty index (FI) was calculated on three occasions over 17 years. Body composition in late midlife included BMI, percent body fat (%BF), waist-to-hip ratio (WHR), lean mass index (LMI), and fat mass index (FMI). Results Mean FI levels increased by 0.28%/year among men and by 0.34%/year among women. Among women, per each kg/m2 higher BMI and each unit higher %BF the increases in FI leve…

El delito de impago de pensiones (art. 227 cp) tras la última jurisprudencia del tribunal supremo español (ssts núms. 346/2020 de 25 de junio; 348/20…

2021

Estudio del art. 207 CP en clave jurisprudencial

Trialling the 4C framework in an Indian grade 3 mathematics classroom

2017

This thesis describes an action research carried out in a Grade 3 maths classroom in a low income, English medium school in Mumbai, India. The maths teacher in the study used the 4C model proposed by Do Coyle (2010) as a framework of Content and Language Integrated Learning (CLIL) for teaching maths in English to students whose exposure to English outside the classroom was negligible. The aim of this research was to understand from a teacher’s perspective how the 4C framework contributed to this specific context and how group-work enhanced the 4C framework. The action research was carried over a period of nearly five months in three cycles. Through the entire duration of the action research…

Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29

2002

Abstract ERp29 is a soluble protein localized in the endoplasmic reticulum (ER) of eukaryotic cells, which is conserved in all mammalian species. The N-terminal domain of ERp29 displays sequence and structural similarity to the protein disulfide isomerase despite the lack of the characteristic double cysteine motif. Although the exact function of ERp29 is not yet known, it was hypothesized that it may facilitate folding and/or export of secretory proteins in/from the ER. ERp29 is induced by ER stress, i.e. accumulation of unfolded proteins in the ER. To gain an insight into the mechanisms regulating ERp29 expression we have cloned and characterized the rat ERp29 gene and studied in details …