Search results for "ERAS"
showing 10 items of 4431 documents
Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study
2021
The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines. An interesting feature of this enzyme comes from its regulation mechanism, which involves its binding to an activating dimer before it can be catalytically functional. Once the trimer is formed, the reaction mechanism proceeds through the deprotonation of the lysine followed by the methyl-transfer reaction. Here we present a detailed exploration of the activation mechanism through a QM/MM approach focusing on both steps of the reaction, aiming to provide new…
Teaching perspectives on CLIL in different educational contexts. Italy, Spain and Turkey
2020
La tesis realiza un estudio comparado internacional sobre el Aprendizaje Integrado de Contenidos y Lenguas Extranjeras (AICLE; en inglés Content and Language Integrated Learning, CLIL) basado en la impartición de diversas materias de una etapa educativa en inglés. El estudio se lleva a cabo en centros educativos de Italia, España y Turquía. El diseño de investigación utiliza un enfoque mixto cualtitativo-cualitativo, con cuestionarios y entrevistas en profundidad como herramientas de recolección de datos. Los datos de la investigación muestran la importancia de la colaboración del profesorado en cuanto a la creación de proyectos, el diseño de materiales, la planificación de las clases y la …
Komētas 67P/Churyumov-Gerasimenko zemas kohēzijas daļiņu elektrostatiskā fragmentācija
2015
Pēc desmit ceļā pavadītiem gadiem un 2.5 gadiem pavadītiem hibernācijas periodā, Eiropas kosmosa aģentūras (angļu: European Space Agency, ESA) izpētes misija Rosetta uz komētu 67P/Churyumov-Gerasimenko ir pilnā datu ieguves režīmā, ar visiem tās 22 zinātniskajiem instrumentiem darbībā, lai izprastu mūsu Saules Sistēmas pirmsākumus. Komētas fizikālais raksturojums parāda, ka tās aptuvenais vidējais blīvums ir ~470 kg/m3 ar relatīvi mīkstu dabu un porozitāti no 70% līdz 80%. Šādām īpašībām apveltītas arī komētas mazākās daļiņas – putekļu graudi, ko parāda Rosettas COSIMA un MIDAS instrumenti - tām ir zema kohēzija tās viegli sadalās. Fizikālie procesi, kas iespējams apraksta šo sadalīšanos ir…
The Philae lander mission and science overview.
2017
The Philae lander accomplished the first soft landing and the first scientific experiments of a human-made spacecraft on the surface of a comet. Planned, expected and unexpected activities and events happened during the descent, the touch-downs, the hopping across and the stay and operations on the surface. The key results were obtained during 12–14 November 2014, at 3 AU from the Sun, during the 63 h long period of the descent and of the first science sequence on the surface. Thereafter, Philae went into hibernation, waking up again in late April 2015 with subsequent communication periods with Earth (via the orbiter), too short to enable new scientific activities. The science return of the…
Sublimation of icy aggregates in the coma of comet 67P/Churyumov–Gerasimenko detected with the OSIRIS cameras on board Rosetta
2016
Beginning in 2014 March, the OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras began capturing images of the nucleus and coma (gas and dust) of comet 67P/Churyumov¿Gerasimenko using both the wide angle camera (WAC) and the narrow angle camera (NAC). The many observations taken since July of 2014 have been used to study the morphology, location, and temporal variation of the comet's dust jets. We analysed the dust monitoring observations shortly after the southern vernal equinox on 2015 May 30 and 31 with the WAC at the heliocentric distance Rh = 1.53 AU, where it is possible to observe that the jet rotates with the nucleus. We found that the decline of brightness a…
Transcriptional Response of Saccharomyces cerevisiae to Different Nitrogen Concentrations during Alcoholic Fermentation▿ †
2007
Gene expression profiles of a wine strain of Saccharomyces cerevisiae PYCC4072 were monitored during alcoholic fermentations with three different nitrogen supplies: (i) control fermentation (with enough nitrogen to complete sugar fermentation), (ii) nitrogen-limiting fermentation, and (iii) the addition of nitrogen to the nitrogen-limiting fermentation (refed fermentation). Approximately 70% of the yeast transcriptome was altered in at least one of the fermentation stages studied, revealing the continuous adjustment of yeast cells to stressful conditions. Nitrogen concentration had a decisive effect on gene expression during fermentation. The largest changes in transcription profiles were o…
Estratigrafía y petrología del subsuelo precuaternario del sector SW de la depresión de Barcelona (Cadenas Costeras Catalanas, NE de Iberia)
2008
Juan.Usera@uv.es Las numerosas obras de Ingeniería Civil que se han realizado en los últimos años en la depresión de Barcelona (ampliación del aeropuerto, ampliación del metro y AVE fundamentalmente) han permitido recabar mucha información sobre el subsuelo de esta área. En este trabajo se caracterizan las distintas unidades de subsuelo precuaternarias que aparecen en los numerosos sondeos realizados recientemente en la zona SW de la depresión de Barcelona. Se ha identificado un sustrato triásico formado por areniscas del Buntsandstein y dos unidades de edad Miocena, una basal de carácter continental y otra superior depositada en un ambiente marino. Todas estas unidades fueron fracturadas d…
El fundamento liberal del derecho a la intimidad
2021
T: The right to privacy is configured as a ?retaining wall? against State interference into the private sphere of people?s life. Throughout this work we will try to expose the philosophical-liberal foundations that have led us to what is now conceived as the ?right to privacy?.
Análisis jurisprudencial de la legitimación pasiva de las entidades financieras en las reclamaciones realizadas por consumidores derivadas de una com…
2021
Consumers, who acquired real estate through a deed of sale with a mortgage subrogation, have made numerous claims against the financial entities. They request the nullity of the clause that imposes upon them all the expenses cause by the notarial deed. Financial entities have alleged that they do not have the capacity to be sued. Courts decisions have been diverse.