Search results for "ERETIC"
showing 10 items of 22 documents
Prevention of endpoints in primary biliary cholangitis with ursodeoxycholic acid: quantifying the benefit
2020
Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid with an established benefit for patients suffering from primary biliary cholangitis (PBC). It was first introduced in the 60s and took until the late 90s to demonstrate a survival benefit in large meta-cohort studies.1 Since then, UDCA is the established first-line therapy according to current guidelines.2 The benefit of UDCA is multidimensional, and patients receiving UDCA experience increased transplant-free survival, a decreased risk of hepatocellular carcinoma and potentially improved quality of life.3–5 The survival benefit is predicted by a number biochemical markers that reflect cholestasis and that are accepted surrogates of the…
Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind, randomised, placebo-controlled, phase 2…
2019
Norursodeoxycholic acid is an orally administered side chain-shortened homologue of ursodeoxycholic acid that undergoes hepatic enrichment with hepatoprotective, anti-inflammatory, and antifibrotic activity. We assessed the efficacy of two doses of norursodeoxycholic acid versus placebo for the treatment of non-alcoholic fatty liver disease.We did a multicentre, double-blind, placebo-controlled, randomised, phase 2 dose-finding clinical trial in tertiary referral hospitals and medical centres in Austria (n=6) and Germany (n=23) for patients with non-alcoholic fatty liver disease with or without diabetes. Patients with a clinical diagnosis of non-alcoholic fatty liver disease and serum alani…
Pregnancy in primary sclerosing cholangitis
2011
Background There is a paucity of data on fertility or pregnancy in patients with primary sclerosing cholangitis (PSC). Objective To assess fertility in PSC by comparing the number of children in a large cohort of PSC patients to healthy controls and to investigate the outcome of pregnancy, as well as the influence of pregnancy on the disease course. Design Case series. Setting Germany. Participants 229 PSC patients and 569 healthy controls were evaluated for the number of children. 17 patients with PSC and at least one pregnancy, or who received a diagnosis of PSC within 6 months after delivery, were included in the more detailed analysis. Main outcome measures Number of children per patien…
Predictive Scores in Primary Biliary Cirrhosis
2015
GOALS The aim of this study was to assess the long-term outcome of primary biliary cirrhosis (PBC) patients and to test the clinical value of various outcome models, such as the Mayo Risk Score (MRS), in a large single-center cohort in Germany. BACKGROUND PBC is a chronic autoimmune liver disease with a female gender predominance and a peak incidence in the fifth decade of life. PBC is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts in liver histology and the presence of antimitochondrial antibodies in the serum of nearly 95% of patients. In 5% to 20% of patients an overlap syndrome with autoimmune hepatitis (AIH) is diagnosed. Ursodeoxycholic…
Combined Therapy with Azathioprine, Prednisolone, and Ursodiol in Patients with Primary Sclerosing Cholangitis: A Case Series
1999
No established medical therapy alters the progressive course of primary sclerosing cholangitis.To explore the potential usefulness of combined therapy with azathioprine, steroids and ursodeoxycholic acid (UDCA) in primary sclerosing cholangitis.Case series.University hospital in Mainz, Germany.15 patients with primary sclerosing cholangitis.Azathioprine (1 to 1.5 mg/kg of body weight per day), prednisolone (1 mg/kg per day initially, tapering to 5 to 10 mg per day) and UDCA (500 to 750 mg per day).Clinical and laboratory evaluation, liver biopsy, and endoscopic retrograde cholangiography (a30% change in stenosis was considered significant).After a median observation period of 41 months (ran…
Pitfalls to be considered on the metabolomic analysis of biological samples by HR-MAS
2014
HR-MAS (High-Resolution Magic AngleSpinning) is considered a powerfultechnique for metabolomic studies ofbiological samples that provides “intact”tissue spectra (Cheng et al., 1998; Waterset al., 2000; Sitter et al., 2002; Martinez-Bisbal et al., 2004; Payne et al., 2006;Coen et al., 2007; Bathen et al., 2010).The performance of HR-MAS, fol-lowed by quantitative histopathology hasdemonstrated that, despite some changes,HR-MAS can preserve approximately thetissue histopathologic features producingwell-resolved spectra of cellular metabo-lites (Cheng et al., 2000). Nevertheless,therearesomeaspectsarousedintheliter-ature about the possible biochemical andstructural changes that can occur durin…
AISF position paper on liver disease and pregnancy.
2016
Abstract The relationship between liver disease and pregnancy is of great clinical impact. Severe liver disease in pregnancy is rare; however, pregnancy-related liver disease is the most frequent cause of liver dysfunction during pregnancy and represents a severe threat to foetal and maternal survival. A rapid differential diagnosis between liver disease related or unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. This report summarizes the recommendation of an expert panel established by the Italian Association for the Study of the Liver (AISF) on the management of liver disease during pregnancy. The article provides an overview of liver disea…
Reply to Dr Michaudet al.
2015
There is no abstract
Control of hysteretic instability in rotating machinery by elastic suspension systems subject to dry and viscous friction
2010
Abstract Most of the undesired whirling motions of rotating machines can be efficiently reduced by supporting journal boxes elastically and controlling their movement by viscous dampers or by dry friction surfaces normal to the shaft axis, which rub against the frame. In the case of dry dampers, resonance ranges of the floating support configuration can be easily cut off by planning a motionless adhesive state of the friction surfaces. On the contrary, the dry friction contact must change automatically into sliding conditions when the fixed support resonances are to be feared. Moreover, the whirl amplitude can be restrained throughout the speed range by a proper choice of the suspension-to-…
Infilled frames: Developments in the evaluation of cyclic behaviour under lateral loads
2005
In order to consider the modified seismic response of framed structures in the presence of masonry infills, proper models have to be formulated. Because of the complexity of the problem, a careful definition of an equivalent diagonal pin-jointed strut, able to represent the horizontal force-interstorey displacement cyclic law of the actual infill, may be a solution. In this connection the present paper, continuing a previous work in which a generalised criterion for the determination of the ideal cross-section of the equivalent strut was formulated, analizes some models known in literature for the prediction of the lateral cyclic behaviour discussing their field of validity. As a support of…