Search results for "EROD"

showing 10 items of 359 documents

Redox signaling in acute pancreatitis

2015

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On th…

NecrosisGSH reduced glutathioneSTAT3 signal transducer and activator of transcription 3ERK extracellular signal-regulated kinasesClinical BiochemistryCCK cholecystokininTRAFs TNF receptor associated factorsReview ArticleIκB kinasePharmacologymedicine.disease_causeBiochemistrySHP small heterodimer partnerSTIM1 stromal interaction molecule 1chemistry.chemical_compoundHATs histone acetyltransferasesMedicineASK1GCL glutamate cysteine ligaseTNF-α tumor necrosis factor alphaIKK IκB kinaseNOS nitric oxide synthaseAcute inflammationHIF hypoxia inducible factorlcsh:QH301-705.5NF-κB nuclear factor kappa BDAMPs damage-associated molecular pattern moleculeslcsh:R5-920biologyGSSG oxidized glutathioneNF-kappa BNLRs nucleotide-binding oligomerization domain (NOD) like receptorsTRADD tumor necrosis factor receptor type 1-associated DEATH domain proteinTRPC3 transient receptor potential channel 3VEGF vascular endothelial growth factorGlutathioneTNFR tumor necrosis factor receptorHMGB1 high-mobility group Box 1 proteinIP3R inositol 145-trisphosphate receptor type 3VCAM-1 Vascular Cell adhesion protein 1Acute DiseaseJNK c-Jun N-terminal kinaseAcute pancreatitisTLRs toll-like receptorsmedicine.symptomlcsh:Medicine (General)Oxidation-ReductionAP-1 activator protein-1Signal TransductionmRNA messenger ribonucleic acidHMGB1ASC apoptosis-associated speck-like protein containing a carboxy-terminal CARDRNS reactive nitrogen speciesPTPs protein tyrosine phosphatasesROS reactive oxygen speciesNADH nicotinamide adenine dinucleotidepHe extracellular pHFAEE fatty acid ethyl estersAP acute pancreatitisHumansXanthine oxidaseCBP CREB-binding proteinRyR endoplasmic reticulum membrane ryanodine receptorsMDA malondialdehydeNO nitric oxideXO xanthine oxidaseASK1 apoptosis signal-regulating kinase-1business.industryOrganic ChemistryAutophagyNADPH nicotinamide adenine dinucleotide phosphateHDACs histone deacetylasesmedicine.diseaseCARS compensatory anti-inflammatory response syndromeXDH xanthine dehydrogenaseIL interleukinIκB inhibitor of kappa BAcute pancreatitisETC Electron transport chainPancreatitisMKPs MAPK phosphatasesSAP severe acute pancreatitischemistrylcsh:Biology (General)DTT dithiothreitolOxidative stressNAC N-acetyl cysteineImmunologybiology.proteinCalciumLysosomesReactive Oxygen SpeciesbusinessMAPK mitogen-activated protein kinaseOxidative stressERCP endoscopic retrograde cholangiopancreatographyRedox Biology
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Neo-clerodane diterpenoids from Teucrium sandrasicum

1997

WOS: A1997XM24100019

Neo-Clerodane DiterpenoidsbiologyStereochemistryPlant ScienceGeneral MedicineLabiataeTeusandrins A-FHorticultureTeucrium Sandiasicumbiology.organism_classificationBiochemistryTeucriumchemistry.chemical_compoundOxetane DerivativeschemistryDiterpeneMolecular BiologyDerivative (chemistry)Phytochemistry
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Nucleus incertus—An emerging modulatory role in arousal, stress and memory

2011

A major challenge in systems neuroscience is to determine the underlying neural circuitry and associated neurotransmitters and receptors involved in psychiatric disorders, such as anxiety and depression. A focus of many of these studies has been specific brainstem nuclei that modulate levels of arousal via their ascending monoaminergic projections (e.g. the serotonergic dorsal raphe, noradrenergic locus ceruleus and cholinergic laterodorsal tegmental nucleus). After years of relative neglect, the subject of recent studies in this context has been the GABAergic nucleus incertus,1 which is located in the midline periventricular central gray in the ‘prepontine’ hindbrain, with broad projection…

NeuronsSystems neuroscienceCognitive NeuroscienceNeuropeptideNucleus IncertusRatsMiceBehavioral NeuroscienceNeuropsychology and Physiological PsychologyLaterodorsal tegmental nucleusmedicine.anatomical_structureDorsal raphe nucleusMemorymedicineAnimalsPeriaqueductal GrayWakefulnessArousalMedial forebrain bundlePsychologyRelaxin-3Neurosciencegamma-Aminobutyric AcidNeuroscience & Biobehavioral Reviews
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Implementation of an aerodynamic lens for TRIGA-SPEC

2016

Abstract We report on the optimization of the gas-jet system employed to couple the TRIGA-SPEC experiment to the research reactor TRIGA Mainz. CdI2 aerosol particles suspended in N2 as carrier gas are used for an effective transport of fission products from neutron induced 235 U fission from the target chamber to a surface ion source. Operating conditions of the gas-jet were modified to enable the implementation of an aerodynamic lens, fitting into the limited space available in front of the ion source. The lens boosts the gas-jet efficiency by a factor of 4–10. The characterization of the gas-jet system as well as the design of the aerodynamic lens and efficiency studies are presented and …

Nuclear and High Energy PhysicsFission products010504 meteorology & atmospheric sciencesChemistrybusiness.industryFissionNuclear engineeringAerodynamics010403 inorganic & nuclear chemistry01 natural sciencesIon source0104 chemical sciencesTRIGAlaw.inventionLens (optics)OpticslawResearch reactorNeutronbusinessInstrumentation0105 earth and related environmental sciencesNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
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Alcune riflessioni sul dono di ospitalità (xenía) nella Grecia antica

2014

OmeroSettore L-ANT/02 - Storia Grecaospitalitàreciprocità M. MauDonoErodoto
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Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies

2007

Therapy-related myelodysplasia and acute myeloid leukemia (t-MDS/AML) is a malignancy occurring after exposure to chemotherapy and/or radiotherapy. Polymorphisms involved in chemotherapy/radiotherapy response genes could be related to an increased risk of developing this neoplasia. We have studied 11 polymorphisms in genes of drug detoxification pathways (NQO1, glutathione S-transferase pi) and DNA repair xeroderma pigmentosum, complementation group (3) (XPC(3), X-ray repair cross complementing protein (1)), Nijmegen breakage syndrome (1), excision repair cross-complementing rodent repair deficiency, complementation group (5) and X-ray repair cross complementing protein (3) and in the methy…

OncologyCancer Researchmedicine.medical_specialtyXeroderma pigmentosumAntineoplastic AgentsBreast NeoplasmsSingle-nucleotide polymorphismPolymorphism Single NucleotideBreast cancerRisk Factorshemic and lymphatic diseasesInternal medicinemedicineHumansMethylenetetrahydrofolate Reductase (NADPH2)Leukemiabiologybusiness.industryHaplotypeMyeloid leukemiaNeoplasms Second PrimaryHematologyMiddle Agedmedicine.diseaseHaplotypesOncologyCase-Control StudiesHematologic NeoplasmsMethylenetetrahydrofolate reductaseImmunologybiology.proteinbusinessNijmegen breakage syndromeNucleotide excision repairLeukemia
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Strong founder effects in BRCA1 mutation carrier breast cancer patients from Latvia

1999

Germ-line mutations of the BRCA1 gene account for approximately half of the cases of hereditary breast/ovarian cancers. We have screened index patients from 15 breast cancer families and 8 sporadic breast cancer patients from Latvia for mutations in all coding exons of the BRCA1 gene, using combined Heteroduplex Analysis/SSCP followed by direct sequencing of the variants. BRCA1 germ-line mutations proved to be frequent in Latvian breast cancer patients, also in moderate-risk families and sporadic patients. Out of 23 cases a total of 8 patients (35%) exhibited three different mutations (5382insC, C61G, 4153delA). Interestingly, these three recurrent mutations accounted for all mutations in o…

OncologyGeneticsmedicine.medical_specialtyMutationDirect sequencingSingle-strand conformation polymorphismBiologymedicine.diseasemedicine.disease_causeExonBreast cancerInternal medicineGeneticsmedicineGenetics (clinical)Brca1 geneFounder effectHeteroduplexHuman Mutation
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Novel P53 mutations detected by FAMA in colorectal cancers

2006

Background The aim of the study was to identify p53 gene mutations by FAMA (fluorescence-assisted mismatch analysis) in colorectal cancers. Patients and methods Analytical scanning of the p53 gene (exons 5–9) was performed in colon cancer samples from 44 consecutive patients by FAMA. FAMA is a semiautomatic scanning approach based on the chemical cleavage of the mismatch in fluorescently labeled heteroduplex DNA, obtained from the combination of a normal and a mutated allele. FAMA has already shown optimal levels of diagnostic accuracy and sensitivity in detecting gene mutations (nucleotide substitutions, insertions/deletions) both at the germline and somatic level. The peculiar feature of …

Oncologymedicine.medical_specialtyMutantDNA Mutational AnalysisMutation MissenseGene mutationmedicine.disease_causeExonInternal medicinemedicineMissense mutationHumansKey words: colon cancer p53 mutations FAMAAlleleGeneMutationbusiness.industryHematologyDNA NeoplasmExonsGenes p53Molecular biologyOncologybusinessColorectal NeoplasmsHeteroduplex
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Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study

2012

Item does not contain fulltext INTRODUCTION: A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (PSORS1C1, TNIP1 and RHOB) as novel genetic risk factors for the disease. The aim of this study was to replicate the previously mentioned findings in a large multicentre independent SSc cohort of Caucasian ancestry. METHODS: 4389 SSc patients and 7611 healthy controls from different European countries and the USA were included in the study. Six single nucleotide polymorphisms (SNP): rs342070, rs13021401 (RHOB), rs2233287, rs4958881, rs3792783 (TNIP1) and rs3130573 (PSORS1C1) were analysed. Overall significance was calculated by pooled analys…

Oncologymedicine.medical_specialtysystemic sclerosisRHOBImmunologyGenome-wide association studySingle-nucleotide polymorphismBioinformaticsPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyArticleWhite PeopleRheumatologyRisk FactorsInternal medicineRhoB GTP-Binding Proteinsystemic sclerosis; genome wide screening; genetic risk factorsmedicinegenetic risk factorsImmunology and AllergySNPHumansGenetic Predisposition to DiseaseAllelerhoB GTP-Binding ProteinRheumatology and AutoimmunityScleroderma Systemicbusiness.industryHaplotypeProteinsgenome wide screeningDNA-Binding ProteinsEuropeHaplotypesCohortEvaluation of complex medical interventions Auto-immunity transplantation and immunotherapy [NCEBP 2]businessGenome-Wide Association Study
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A multi-technique simultaneous approach for the design of a sailing yacht

2015

In this paper, most significant steps involved during the whole process of designing a sailing yacht are outlined. In particular, a novel simultaneous approach has been proposed to optimize the design process of a sailing yacht. Analytical resistance prediction models are simultaneously used with CAD systems and computational fluid dynamics tools to find, in the more effective way, the best solution for the chosen design conditions. As a general rule, in fact, once the target point has been decided, task of the designer is the definition of those systems of aerodynamic and hydrodynamic forces that are in equilibrium when the boat sails at its target. Unfortunately, a multi-purpose yacht doe…

OptimizationEngineeringProcess (engineering)020101 civil engineering02 engineering and technologyNumerical method01 natural sciencesIndustrial and Manufacturing Engineering010305 fluids & plasmas0201 civil engineeringModeling and simulationConceptual designComputational fluid dynamicIndustrial designHull0103 physical sciencesPoint (geometry)Settore ING-IND/15 - Disegno E Metodi Dell'Ingegneria Industrialebusiness.industryAerodynamicsModeling and SimulationConceptual designSailing yachtEngineering design processbusinessMarine engineering
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