Search results for "EROI"
showing 10 items of 1497 documents
Small molecule modulators of amine oxidation, nuclear receptor signaling and glucuronidation : 3-phenylcoumarin as a scaffold of interest
2018
The costs of the drug development process are moderated as computer-aided drug design methods are able to expedite the steps required for lead identification. In fact, computational tools are nowadays virtually indispensable from target identification and validation to preclinical tests due to exponential growth of available information regarding both potential targets and small molecules. One such small molecule with growing number of variations is coumarin. Coumarin scaffold and its various derivatives continue to interest researchers for their vast application potential. Since naturally occurring coumarins are known for example for their antioxidant and anti-inflammatory properties, thos…
Acute responses of comprehensive gonadosteroids and corticosteroids to resistance exercise before and after 10 weeks of supervised strength training
2020
Resistance training is a potent stimulus for muscle growth and steroid hormones are known to play a role in this adaptation. However, very little is known about the acute exercise‐induced gonadosteroid and corticosteroid hormone responses, including key smaller‐concentration intermediate hormones. The present study determined the acute responses of these steroid hormone families using quantitative UHPLC mass spectrometry (MS) following resistance exercise in strength‐trained men. Venous and fingertip blood was drawn pre‐, mid‐, 5 min post‐ and 15 min post‐resistance exercise, both before and after 10 weeks of supervised resistance training. The experimental resistance exercise sessions cons…
Adverse reactions to the injection of face and neck aesthetic filling materials: a systematic review
2022
Adverse reactions, caused during the inflammation and healing process, or even later, can be induced by the injection of dermal filler and can present a variety of clinical and histological characteristics. In this study we aimed to review the adverse reactions associated with the injection of aesthetic filling materials in the face and neck. The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Studies published that mentioned adverse reactions in patients with aesthetic filling materials in the face or neck were included. Risk of bias was assessed using the Joanna Briggs Institute appraisal tool. After a 2-step selection pro…
Ancora sulle stele e le edicole dipinte di Lilibeo: immagini, formule, funzioni
2020
Il contributo esamina le stele e i naiskoi funerari dipinti di Lilibeo (Sicilia), recentemente incrementati da due nuove acquisizioni. Sono presi in considerazione i (pochi) dati contestuali, oltre a tipologia, iconografia e formule epigrafiche, allo scopo di mettere in luce specificità, funzioni e messaggi di tali manufatti. Alcuni elementi “trasversali” di carattere antiquario e stilistico, oltre ai dati epigrafici, attestano una sostanziale contemporaneità delle stele più semplici con singolo personaggio stante, con melograno in mano, e dei più elaborati naiskoi con “Totenmahlmotiv”, nella tarda età repubblicana. Le chiare differenze di morfologia, iconografia, formule epigrafiche e luog…
Kolmiulotteisen maaston generointi peleissä
2015
Monet tietokonepelit toteuttavat kolmiulotteisen maaston käyttäen korkeuskarttoja. Korkeuskartan luominen käsin on kuitenkin työlästä. Pelinkehityksen helpottamiseksi korkeuskarttoja voidaan generoida osittain tai täysin proseduraalisesti. Tässä tutkielmassa käsitellään erilaisia korkeuskartan generointimenetelmiä. Tutkielmassa kuvaillaan myös erilaisia eroosio-algoritmeja, joilla generoiduista maastoista saadaan realistisempia. Lopuksi pohditaan, kuinka esitettyjä menetelmiä voidaan hyödyntää peleissä. Many computer games implement three-dimensional terrain using heightmaps, but creating a heightmap by hand is tedious. To make game development easier heightmaps can be generated partially o…
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.
2011
http://www.sciencedirect.com/; International audience; Free cholesterol is the predominant form of cholesterol in the neural retina. The vertebrate neural retina exhibits its own capacity to synthesize cholesterol and meets its demand also by taking it from the circulation. Defects in cholesterol synthesis and trafficking in the neural retina has detrimental consequences on its structure and function, highlighting the crucial importance of maintaining cholesterol homeostasis in the retina. Our purpose was to give a review on the functioning of the retina, the role of cholesterol and cholesterol metabolism therein, with special emphasis on cholesterol-24S-hydroxylase (CYP46A1). Similar to th…
Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on topical therapy in ulcerative colitis
2020
Although most patients with ulcerative colitis should be given topical treatment, different studies have shown that they are underused in clinical practice. The purpose of this article is to answer 10 specific questions about which drugs are available for topical use in the treatment of ulcerative colitis, and their characteristics in terms of formulation, dosage, presentation, application and proximal distribution of rectal-administered drugs. The efficacy of available topical drugs and the benefits of combining different formulations and routes of administration, and their usefulness during disease remission are evaluated. Finally, a series of recommendations addressed to patients are giv…
Esteroide anabolizanteak. Goi mailako kirol alorretik gimnasioetara
2013
El presente estudio pretende caracterizar sociológicamente el consumidor recreativo de esteroides anabolizantes en tierras valencianas. La investigación se desarrolla así a partir de la aplicación de una metodología explícitamente cualitativa y la puesta en práctica de la técnica de la entrevista semiestructurada. El perfil sociológico del consumidor recreativo de esteroides anabolizantes se caracteriza por un bajo nivel de estudios, cierta inestabilidad laboral vinculada a menudo con el mundo del ocio nocturno y de la seguridad tanto privada como pública, problemas familiares, gusto por las discotecas y la playa, y frecuentes rupturas en sus relaciones de pareja, entre otros aspectos. Se c…
El terrorisme suïcida: una hipòtesi evolucionista sobre el suïcidi
2012
Un intent d'abordar la problemàtica terrorista suïcidi com a pas previ per a una explicació més comprensiva del suïcidi, des d'un punt de vista evolucionista, amb la intenció d'incorporar les conseqüències antropològiques pertinents de manera que es puga reformular tot el procés d'hominització i humanització, congruentment amb les dades estadístiques, científiques i fenomenològiques. An essay on suicide terrorism previous toward a more comprehensive explanation of suicide, from an evolutionary point of view, with the aim of taking into account the anthropological consequences for the human development, all including the statistics and scientifics issues and philosophycal as well.
Drogas y salud familiar
2000
Las familias son el grupo social sobre quien recaen más directamente las consecuencias negativas de las adicciones de sus miembros. Estas consecuencias no sólo abarcan as¬pectos económicos y sociales, sino que se extienden a los ámbitos de la salud psíquica y física de cada uno de los miembros no drogadictos.En nuestro trabajo, hemos pretendido describir las variaciones en conductas, senti¬mientos, sensaciones, imaginaciones, cogniciones, relaciones interpersonales y salud (si¬guiendo el modelo BASIC.ID de A.A. Lazarus) que han experimentado los padres y madres de heroinómanos a partir del conocimiento de la adicción de sus hijos. Hemos pasado una entrevista semiestructurada, elaborada por …