Search results for "ESAL"
showing 10 items of 229 documents
Design, characterization and in vitro evaluation of 5-aminosalicylic acid loaded N-succinyl-chitosan microparticles for colon specific delivery
2011
The objective of this study was to prepare NS-chitosan microparticles for the delivery of 5-aminosalicylic acid (5-ASA) to the colon. Microparticles can spread out over a large area of colon allowing a more effective local efficacy of 5-ASA. N-Succinyl-chitosan was chosen as carrier system because of its excellent pharmaceutical properties in colon drug targeting such as poor solubility in acid environment, biocompatibility, mucoadhesive properties, and low toxicity. It was prepared by introducing succinic group into chitosan N-terminals of the glucosamine units. 5-ASA loaded NS-chitosan microparticles were prepared using spray-drying. As a control, a matrix obtained by freeze-drying techni…
La resale price maintenance nel commercio librario. Limitare la concorrenza per promuovere la cultura?
2013
Traendo spunto dalle vicende della legge n. 128/2011, che limita lo sconto massimo praticabile al pubblico sul prezzo di copertina dei libri, pprovata con largo consenso e presto abrogata nell’indifferenza generale, l’articolo propone una approfondita analisi del modello nel quale tale legge si inscrive e delle soluzioni alternative che si riscontrano nel contesto europeo. L’indagine intende, quindi, riflettere sulla fondatezza degli assunti tradizionalmente posti alla base della difesa della Rpm libraria. Taking the cue from the events of the Law n. 128/2011, limiting the discounts on books cover price, which was passed by broad consensus and soon implicitly repealed amid the general indif…
Two mesalazine regimens in the prevention of the post-operative recurrence of Crohn's disease: a pragmatic, double-blind, randomized controlled trial
2003
Summary Background : The role of mesalazine in preventing the clinical recurrence of Crohn's disease after surgery has been shown in a meta-analysis of all published studies. No clear relationship, however, has been shown between dosage and response. Aim : To evaluate whether 4.0 g/day of mesalazine may offer therapeutic advantages over 2.4 g/day in the prevention of both endoscopic and clinical post-operative recurrence of Crohn's disease. Methods : The study was a double-blind, randomized, multi-centre, prospective, controlled clinical trial. Two hundred and six patients, submitted to first or second intestinal resection for Crohn's disease limited to the terminal ileum, with or without i…
New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
2020
[EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a th…
The Economic Impact of Restricted Water Supply: a Computable General Equilibrium Analysis
2007
Water problems are typically studied at the level of the river catchment. About 70% of all water is used for agriculture, and agricultural products are traded internationally. A full understanding of water use is impossible without understanding the international market for food and related products, such as textiles. The water embedded in commodities is called virtual water. Based on a general equilibrium model, we offer a method for investigating the role of water resources and water scarcity in the context of international trade. We run five alternative scenarios, analyzing the effects of water scarcity due to reduced availability of groundwater. This can be a consequence of physical con…
Perspectives of operation of the Tajo-Segura Transfer (Spain): new rules of operation and the impulse of the desalination as replacement resource
2018
El Trasvase Tajo-Segura se ha convertido desde su inauguración en 1979 en una de las infraestructuras hidráulicas que más tensiones interterritoriales ha originado en España. A ello se une su valor estratégico para el desarrollo de las provincias del sureste peninsular, donde atiende consumos agrícolas y urbano-turísticos con grandes implicaciones sociales y económicas. El objetivo de este trabajo es analizar las causas y las consecuencias del funcionamiento del Trasvase Tajo-Segura con la reciente modificación de sus normas de explotación (límite de no trasvase cuando en los embalses de cabecera almacenen menos de 400 hm3) y el impulso de la desalinización en la cuenca receptora como susti…
Estimating willingness to pay for desalinated seawater: the case of Djerba Island, Tunisia
2017
AbstractWater scarcity can be a growth-limiting factor. Non-conventional water resources, such as desalinated water, represent an alternative means of guaranteeing access to water while reducing water stress. In this study, a contingent valuation survey carried out in Djerba Island, Tunisia, allows the joint modelling of two decisions: societal support for the construction of a desalination plant and households’ willingness to pay for desalinated water. To the best of the authors’ knowledge, no study to date has addressed this relationship. We find that although a clear majority of households are in favour of using desalinated water, far fewer are willing to pay for it. The article conclude…
Olleros, alfareros y fabricantes de loza en Ribesalbes, entre 1742 y 1817
2012
El desarrollo de la tradición alfarera en Ribesalbes, y el posterior establecimiento de las primeras fábricas de loza, a finales del siglo XVIII, viene determinado por los condicionantes naturales e históricos de la villa; así como por la influencia decisiva de la Real Manufactura del conde de Aranda, en la vecina población de L’Alcora. En este trabajo, a partir de diversas fuentes documentales primarias, entre las que cabe destacar los libros sacramentales del Archivo Parroquial de Ribesalbes, y la Contribución general de 1817, se constata la presencia de olleros en la Baronía, a principios del siglo XVIII. Se determinan también los nombres de algunos alfareros, registrados en los albores …
Mining minerals and critical raw materials from bittern: Understanding metal ions fate in saltwork ponds
2022
Seawater represents a potential resource for raw materials extraction. Although NaCl is the most representative mineral extracted other valuable compounds such as Mg, Li, Sr, Rb and B and elements at trace level (Cs, Co, In, Sc, Ga and Ge) are also contained in this “liquid mine”. Most of them are considered as Critical Raw Materials by the European Union. Solar saltworks, providing concentration factors of up-to 20 to 40, offer a perfect platform for the development of minerals and metal recovery schemes taking benefit of the concentration and purification achieved along the evaporation saltwork ponds. However, the geochemistry of these elements in this environment has not been yet thoroug…
Los mamíferos del Mioceno Inferior de la Cuenca de Ribesalbes-Alcora (Castelló, España)
2017
Objetivos El propósito principal de esta tesis es el estudio taxonómico, paleoecológico y bioestratigráfico de los mamíferos fósiles del Neógeno continental de Araia d’Alcora, en la Cuenca de Ribesalbes-Alcora (Castelló, España), a partir de la prospección de diversas secciones y del muestreo de los yacimientos de mayor interés. Los principales objetivos planteados en esta tesis han sido: • La obtención de un registro lo más completo posible de las faunas de mamíferos del área de estudio, mediante la identificación de niveles fosilíferos y la toma de muestras suficientemente grandes para obtener colecciones de fósiles representativas. • Determinación taxonómica de los grupos de mamíferos ha…