Search results for "ESMO"

Acceso a la innovación farmacéutica en cáncer. Análisis sistemático

2022

Los precios de los fármacos oncológicos están creciendo de manera muy pronunciada y junto a un aumento considerable de la incidencia de esta patología, hacen que sea necesario abordar el tema de la asequibilidad, equidad y calidad del cuidado de la salud en cáncer si no queremos que los diferentes sistemas nacionales de salud entren en bancarrota. Se han generado muchas iniciativas cuyo objetivo es evaluar el beneficio clínico de las intervenciones y así, se financien aquellas intervenciones que aporten un mayor valor tanto para los pacientes oncológicos como para la sociedad en general. Esta tesis realiza un análisis de las diferentes herramientas e iniciativas puestas en marcha por los si…

El último intelectual

2007

Zvaigžņotā Debess: 2007/08, Ziema

2007

Latvijas Zinātnes padome, Latvijas Universitāte

Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells

2017

Langerhans cells (LCs) are antigen-presenting cells in the epidermis whose roles in antigen-specific immune regulation remain incompletely understood. Desmoglein 3 (Dsg3) is a keratinocyte cell-cell adhesion molecule critical for epidermal integrity and an autoantigen in the autoimmune blistering disease pemphigus. Although antibody-mediated disease mechanisms in pemphigus are extensively characterized, the T cell aspect of this autoimmune disease still remains poorly understood. Herein, we utilized a mouse model of CD4+ T cell-mediated autoimmunity against Dsg3 to show that acquisition of Dsg3 and subsequent presentation to T cells by LCs depended on the C-type lectin langerin. The lack of…

Subcellular Localization of β-Catenin Is Regulated by Cell Density

2002

It is generally accepted that subcellular distribution of beta-catenin regulates its function. Membrane-bound beta-catenin mediates cell-cell adhesion, whereas elevation of the cytoplasmic and nuclear pool of the protein is associated with an oncogenic function. Although the role of beta-catenin in transformed cells is relatively well characterized, little is known about its importance in proliferation and cell-cycle control of nontransformed epithelial cells. Using different approaches we show that in human keratinocytes (HaCaT) beta-catenin is distributed throughout the cells in subconfluent, proliferating cultures. In contrast, beta-catenin is nearly exclusively located at the plasma mem…

The cell adhesion domain of type XVII collagen promotes integrin-mediated cell spreading by a novel mechanism.

2001

Type XVII collagen (BP180) is a keratinocyte transmembrane protein that exists as the full-length protein in hemidesmosomes and as a 120-kDa shed ectodomain in the extracellular matrix. The largest collagenous domain of type XVII collagen, COL15, has been described previously as a cell adhesion domain (Tasanen, K., Eble, J. A., Aumailley, M., Schumann, H., Baetge, J, Tu, H., Bruckner, P., and Bruckner-Tuderman, L. (2000) J. Biol. Chem. 275, 3093-3099). In the present work, the integrin binding of triple helical, human recombinant COL15 was tested. Solid phase binding assays using recombinant integrin alpha(1)I, alpha(2)I, and alpha(10)I domains and cell spreading assays with alpha(1)beta(1)…

Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris.

2008

We have previously demonstrated that serum of patients with pemphigus vulgaris induces reduction of desmoglein 3 (Dsg3) half-life in keratinocytes (FEBS Lett 2006: 580: 3276). This phenomenon seems to occur as a consequence of the progressive depletion of Dsg3 from desmosomes. Here we reported that reduction of full-length Dsg3 may be due to its progressive cleavage, leading to the formation of two fragmentation products with apparent molecular masses of about 60 kDa (fragment 1) and 70 kDa (fragment 2), as revealed by Western blotting. Unexpectedly, analysis of fragmentation pattern suggested cleavage to occur intracellularly. Consistently, fragment 1 was shed and localized within the cyto…

In regard to “A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle-cell neoplasms”

2018

Effective Linear Friction Welding Machine Redesign through Process Analysis

2014

Linear friction welding is a solid-state joining process developed for non-axisymmetric components in which the joining of the specimens is obtained through reciprocating motion and pressure. In the process, the friction forces work due to the high frequency oscillation and the pressure between the specimens is converted in thermal energy. In order to design an effective machine, relevant issues derive from the high frequency and the large inertial forces involved in the process. In this study, the authors describe the redesign of a preexisting prototypal machine for LFW processes. A machine redesign is needed when welding high resistant materials, i.e. steels or titanium alloys, with high …

Tumor dedifferentiation: an important step in tumor invasion.

1985

Tumor invasion in vivo was studied by light and electron microscopy as well as by immunofluorescence microscopy. Special regard was paid to the grade of tumor differentiation. Dimethylhydrazine-induced murine colonic carcinomas comprising a differentiated and an undifferentiated tumor type with low and high invasiveness respectively, were used. At the invasion front of both tumor types a striking dissociation of the organized tumor cell complexes into isolated tumor cells was found together with a loss of most of the cytological features of differentiation. It is supposed that this process mobilizes the tumor cells from the main tumor bulk enabling them to invade the host tissue by active l…