Search results for "ESOL"

Bioorthogonal red and far-red fluorogenic probes for wash-free live-cell and super-resolution microscopy

2020

AbstractSmall-molecule fluorophores enable the observation of biomolecules in their native context with fluorescence microscopy. Specific labelling via bioorthogonal tetrazine chemistry confers minimal label size and rapid labelling kinetics. At the same time, fluorogenic tetrazine-dye conjugates exhibit efficient quenching of dyes prior to target binding. However, live-cell compatible long-wavelength fluorophores with strong fluorogenicity have been difficult to realize. Here, we report close proximity tetrazine-dye conjugates with minimal distance between tetrazine and fluorophore. Two synthetic routes give access to a series of cell permeable and impermeable dyes including highly fluorog…

Investigation of molecular mobility and crystalline order in polyethylene by high resolution nuclear magnetic resonance

2007

Methacrylate ester-based monolithic columns for nano-LC separation of tocopherols in vegetable oils

2010

The separation and determination of tocopherols (Ts) in vegetable oils by nano-LC chromatography with UV-vis detection using lauryl methacrylate ester-based monolithic columns has been developed. The separation of Ts was optimized in terms of mobile phase composition on the basis of the best compromise among efficiency, resolution and analysis time. Using a mobile phase composed of ACN/methanol/water, an excellent resolution between Ts was achieved within 18 min. The LODs were lower than 0.26 μg/mL, being repeatability values of retention time and peak area below 0.15 and 3.1%, respectively. The method was applied to the quantification of Ts and tocotrienols present in several vegetable oil…

Racemattrennung, Kristallstruktur und histaminartige Wirkung von 4-[1-(2-Aminoethylthio)ethyl]-5-methylimidazol

1983

Es wird die Racemattrennung von 4-[1-(2-Aminoethylthio)ethyl]-5-methylimidazol (1) mittels optisch aktiver Di-O-(p-toluoyl)weinsaure sowie die histaminartige Wirksamkeit der Enantiomeren beschrieben. Von (+)-1 · 2HCl · H2O wurde die Kristallstruktur bestimmt und bis zu einem R-Wert von 0.0483 verfeinert. Danach ist (+)-1R-konfiguriert. Von den beiden Enantiomeren besitzt nur (S)-(−)-1 H1-agonistische Aktivitat. Resolution, Crystal Structure, and Histamine-like Activity of 4-[1-(2-Aminoethylthio)ethyl]-5-methylimidazole The resolution of racemic 4-[1-(2-aminoethylthio)ethyl]-5-methylimidazole (1) using optically active Di-O-(P-toluoyl)tartaric acid as well as the histamine-like activity of t…

Polymorphism of R-Encenicline Hydrochloride: Access to the Highest Number of Structurally Characterized Polymorphs Using Desolvation of Various Solva…

2019

In a study of the solid form landscape of R-encenicline hydrochloride (Enc-HCl), it was found that this compound is dodecamorphic and presents the first published example of polymorphism with a rec...

Controlling Spin-Correlated Radical Pairs with Donor-Acceptor Dyads: A New Concept to Generate Reduced Metal Complexes for More Efficient Photocataly…

2021

Abstract One‐electron reduced metal complexes derived from photoactive ruthenium or iridium complexes are important intermediates for substrate activation steps in photoredox catalysis and for the photocatalytic generation of solar fuels. However, owing to the heavy atom effect, direct photochemical pathways to these key intermediates suffer from intrinsic efficiency problems resulting from rapid geminate recombination of radical pairs within the so‐called solvent cage. In this study, we prepared and investigated molecular dyads capable of producing reduced metal complexes via an indirect pathway relying on a sequence of energy and electron transfer processes between a Ru complex and a cova…

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

2021

Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the rol…

Multiscale variation in drought controlled historical forest fire activity in the boreal forests of eastern Fennoscandia

2017

Forest fires are a key disturbance in boreal forests, and characteristics of fire regimes are among the most important factors explaining the variation in forest structure and species composition. The occurrence of fire is connected with climate, but earlier, mostly local-scale studies in the northern European boreal forests have provided little insight into fire-climate relationship before the modern fire suppression period. Here, we compiled annually resolved fire history, temperature, and precipitation reconstructions from eastern Fennoscandia from the mid-16th century to the end of the 19th century, a period of strong human influence on fires. We used synchrony of fires over the network…

Compete and Compromise: Machiavellianism and Conflict Resolution

2014

The aim of our present study was to examine Machiavellians’ conflict management styles that have been neglected in previous research. One hundred eighty three participants completed the Thomas-Kilmann Instrument and the Mach-IV test. A positive correlation was found between the scores on the Mach scale and the scores on the Competing and Compromising subscales, while a negative correlation was found between Mach scores and Avoiding and Accommodating scores. These results coincide with findings on the Machiavellians’ assertive, opportunistic and flexible strategies. Using the adequate problem solving strategies, Machiavellians can successfully adapt to the requirements of a given situation, …

El supuesto práctico de las oposiciones del 2018 de la Comunidad Valenciana para el cuerpo de maestros/as de Educación Infantil

2018

En este documento se encuentra la resolución del supuesto práctico que se planteó en la Comunidad Valenciana durante las oposiciones del año 2018 para el cuerpo de maestros de Educación Infantil. Respondiendo al diseño de una propuesta didáctica contextualizada en los lenguajes plástico, musical y corporal. Atendiendo a la organización y espacios de la misma. Teniendo en cuenta que el centro sigue un programa de tutorización entre Educación Infantil y Primaria y una metodología basada en el Aprendizaje Basado en Proyectos. This document contains the resolution of the practical assumption that was raised in the Valencian Community during the 2018 competitive examinations for early Childhood …