Search results for "EVALUATE"

showing 10 items of 24 documents

Integrazione di celle solari di terza generazione nel vetromattone per la realizzazione di pannelli traslucidi fotovoltaici. Analisi prestazione e st…

2013

L’articolo illustra i primi risultati ottenuti nell’ambito dell’analisi prestazionale del vetromattone fotovoltaico, un prodotto edilizio innovativo derivato dall’integrazione di celle fotovoltaiche di terza generazione (DSSC) nel vetromattone, ideato per la realizzazione di involucri traslucidi energeticamente effi cienti ed “attivi”, in grado di ridurre i consumi energetici degli edifi ci e di produrre, al contempo, energia verde. L’analisi è stata condotta su quattro differenti ipotesi di integrazione. Attraverso simulazioni numeriche si è effettuata una valutazione dell’energia assorbita dagli strati attivi oltre che delle prestazioni ottiche complessive del dispositivo. Lo studio anali…

In this article the fi rst results of the performance analysis of the photovoltaic glassblock are given. The photovoltaic glassblock is an innovative product which integrates third generation solar cells (DSSC) invented for the construction of translucent building envelopes energetically effi cient and “active” able to reduce the energy consumption in buildings and to produce at the same time green energy. The analysis was conducted on four different hypotheses of integration through numerical simulations in order to evaluate the energy absorption and the optical performance of the device. The software simulations represent a fi rst step for the understanding of the performance of the element and prelude to an experimental analysis session. The results of a research conducted about national and international patents publications on the DSSC technology and its applications will be illustrated too. The data collected during this research had been organized in a digital database.Settore ICAR/10 - Architettura Tecnica
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Diagnosis and therapeutic management of primary headache in an emergency setting

2013

Introduction and aim: Much headachers are under or mis-diagnoses and data regarding the proportion of patients attending an emergency department (ED) because of headache are still few. We conducted a retrospective observational study in an ED with the following aims: (a) estimate the proportion of headache attending to an ED (b) to estimate and describe the therapeutic management of primary headache and (c) to assessment the exam most frequently requested. Materials and methods: We collected data regarding patients diagnosed with headache consecutively attending the ED of the University of Palermo between September 2011 and March 2012. The study was approved by the ethics committee. Results: Between the semester evaluated 25110 subjects were admitted to ED headache suffers were equal to 1.6 %. Of these 263 (63.1 %) were woman and 154 (36.9 %). Mean age was 44.2 (DS ± 18.4) years (p = 0.068).According to ED registry headache admission was as follow assigned: 76.5 % with a diagnosis of headache 22.8 % with a secondary headache 0.7 % with Trigeminal Autonomic Cephalgias (TACs). Among those with a primary headache about 36 % of patient did not received a pharmacological treatment. Monotherapy was prescribed less frequently than combination therapy (19.1 vs 44.5 %).In monotherapy the most frequent medication were NSAIDs (28.3 %) benzodiazepines (26.7 %) and dopamine antagonists (11.7 %). Among those with a primary headache a CT scan was performed in the 124 subjects and 111 (34.8 %) had a neurologist consultation. Discussion: Our data are in line with the one previously reported in literature. The most frequently medication in the Italian ED were NSAIDs benzodiazepines dopamine antagonists and steroids. Neverless our data unlikely can be compared to other study give a snapshot. We believe that much more can be done to improve treatment of primary headache in ED.Settore MED/26 - Neurologia
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Re-treatment of Patients With Chronic Hepatitis C Who Do Not Respond to Peginterferon-[alpha]2b: A Randomized Trial

2009

BACKGROUND Many patients with chronic hepatitis C have not responded to therapy with pegylated interferon plus ribavirin. OBJECTIVE To evaluate use of peginterferon-alpha2a plus ribavirin to re-treat nonresponders to peginterferon-alpha2b plus ribavirin. DESIGN Randomized, parallel-group trial conducted between September 2003 and February 2007. Patients and researchers were not blinded to intervention assignment. Random assignment was centralized, computer-generated, and stratified by geographic region, hepatitis C virus (HCV) genotype, and histologic diagnosis. SETTING 106 international centers. PATIENTS 950 nonresponders to 12 or more weeks of therapy with peginterferon-alpha2b plus ribav…

Malemedicine.medical_specialtyHepatitis C virusAlpha interferonHepacivirusInterferon alpha-2medicine.disease_causeAntiviral AgentsGastroenterologyDrug Administration SchedulePolyethylene Glycolslaw.inventionchemistry.chemical_compoundDouble-Blind MethodRandomized controlled triallawPegylated interferonInternal medicineRibavirinInternal Medicineretreatment non responder hepatitis CHumansMedicineTreatment FailureNot evaluatedbusiness.industryRibavirinInterferon-alphavirus diseasesGeneral MedicineHepatitis CHepatitis C ChronicMiddle Agedmedicine.diseaseRecombinant Proteinsdigestive system diseasesSurgerychemistryRetreatmentRNA ViralDrug Therapy CombinationFemalebusinessViral loadmedicine.drug
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Analysis of risk factors for restenosis after PTCA

1990

To identify risk factors for restenosis, we evaluated data in 473 patients with single-vessel percutaneous transluminal coronary angioplasty (PTCA) and control angiography after 6 months. Restenosis, defined as (1) loss greater than 50% of the initial gain, and (2) stenosis greater than 50% was found in 138 patients (29.2%). Univariate analysis revealed eight factors related to restenosis: (1) duration of symptoms less than 1 month (P = 0.005), (2) unstable angina (P = 0.004), (3) high-grade stenosis before PTCA (P = 0.014), (4) large residual stenosis after PTCA (P = 0.001), (5) insufficient improvement of stenosis (P = 0.042), (6) prolonged single inflation time (P = 0.017), (7) prolonged…

Malemedicine.medical_specialtyPercutaneous transluminal coronary angioplastyCoronary DiseaseCoronary AngiographyRestenosisRecurrenceRisk FactorsInternal medicinemedicineHumansAngina Unstablecardiovascular diseasesAngioplasty Balloon CoronaryAgedAnalysis of VarianceUnivariate analysismedicine.diagnostic_testbusiness.industryUnstable anginaResidual stenosisMiddle Agedmedicine.diseaseCoronary VesselsStenosisAngiographyCardiologyEvaluated dataCardiology and Cardiovascular MedicinebusinessCatheterization and Cardiovascular Diagnosis
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Nuclear Data Sheets for A=188

2018

Abstract Evaluated nuclear structure and decay data for all nuclei with mass number A=188 (Lu, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po) are presented. The experimental data are compiled and evaluated, and best values for level and gamma-ray energies, quantum numbers, lifetimes, gamma-ray intensities, and other nuclear properties are recommended. Inconsistencies and discrepancies that exist in the literature are noted. This work supersedes the earlier evaluation by Balraj Singh (2002Si10), published in Nuclear Data Sheets 95, 387 (2002). The gamma-ray transition probabilities were calculated using the ENSDF analysis program ruler ( www-nds.iaea.org/public/ensdf_pgm/ ). However, the…

Mass numberPhysicsNuclear and High Energy Physicsta114010308 nuclear & particles physicsevaluated nuclear structureNuclear structureNuclear dataExperimental dataQuantum number01 natural sciencesNuclear physics0103 physical sciences010306 general physicsNuclear Data Sheets
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Nurse-based monitoring and management of breakthrough pain in an acute pain relief and palliative care unit

2016

To assess the nurses' performance in assessing, treating, and documenting breakthrough pain (BTP) in a palliative care unit where traditionally there is continuous training.The study was performed in an acute palliative care unit. Once a week, a research nurse examined the documentation regarding all the episodes of BTP registered in a specific pain chart, designed by the institutional nurse board, as part of the routine nurse activity.The charts of 50 consecutive eligible patients (32 M/18 F), were analysed. The mean number of episodes/patient was 3.3 (SD 1.61; range 1-7). 166 episodes occurred. The main BTP pain intensity was 7.06 (SD 0.82). In 7 episodes, pain intensity was not evaluated…

Not evaluatedPalliative carebusiness.industryassessmentBreakthrough PainopioidsGeneral Medicinebreakthrough pain03 medical and health sciences0302 clinical medicinenursingNursing030220 oncology & carcinogenesisMedicine030212 general & internal medicineCancer painbusinessCancer painAcute painHospital Practice
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Disposition ofd-penicillamine, a promising drug for preventing alcohol-relapse. Influence of dose, chronic alcohol consumption and age: studies in ra…

2014

Pharmacokinetic studies concerning d-penicillamine (an acetaldehyde sequestering agent) are scarce and have not evaluated the influence of chronic ethanol consumption and age on its disposition. Since recent preclinical studies propose d-penicillamine as a promising treatment for alcohol relapse, the main aim of the present work was to evaluate the influence of these two factors on d-penicillamine disposition in order to guide future clinical studies on the anti-relapse efficacy of this drug in alcoholism. Additionally, the effect of the administered dose was also evaluated. To this end, three studies were carried out. Study 1 assessed the influence of dose on d-penicillamine disposition, w…

PharmacologyDrugNot evaluatedEthanolbusiness.industrymedia_common.quotation_subjectPenicillamineAcetaldehydePharmaceutical ScienceAlcoholGeneral MedicineDispositionPharmacologychemistry.chemical_compoundPharmacokineticschemistrymedicinePharmacology (medical)businessmedia_commonmedicine.drugBiopharmaceutics & Drug Disposition
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Compilation and Evaluation of Beta-Delayed Neutron Emission Probabilities and Half-Lives for Z > 28 Precursors

2020

Abstract We present a compilation and evaluation of experimental β-delayed neutron emission probabilities (Pn) and half-lives (T1/2) for known or potential β-delayed neutron precursors with atomic number Z > 28 (73Cu–233Fr). This article includes the recommended values of both of these quantities, together with a compilation of experimental measurements when available. Some notable cases, as well as proposed standards for β-delayed neutron measurements are also discussed. Evaluated data has also been compared to systematics using three different approaches. The literature cut-off date for this work is August 15, 2020.

PhysicsNuclear and High Energy Physics010308 nuclear & particles physicsNeutron emissionNuclear data01 natural sciencesNuclear physics0103 physical sciencesEvaluated dataNeutronBeta (velocity)Atomic number010306 general physicsDelayed neutronNuclear Data Sheets
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Are analysts doing method validation in liquid chromatography?

2014

International audience; Method validation is being applied in the reported analytical methods for decades. Even before this protocol was defined, authors already somehow validated their methods without full awareness. They wished to assure the quality of their work. Validation is an applied approach to verify that a method is suitable and rugged enough to function as a quality control tool in different locations and times. The performance parameters and statistical protocols followed throughout a validation study vary with the source of guidelines. Before single laboratory validation, an analytical method should be fully developed and optimized. The purpose of the validation is to confirm p…

Quality ControlValidation studyDIODE-ARRAY DETECTIONMethod validationmedia_common.quotation_subjectLiquid chromatographyValidation Studies as TopicGuidelinesBiochemistryField (computer science)Analytical Chemistry[CHIM.ANAL]Chemical Sciences/Analytical chemistrySIMPLE HPLC METHODHumansQuality (business)HUMAN PLASMATANDEM MASS-SPECTROMETRYRAT PLASMAFunction (engineering)SurveyRP-LC METHODmedia_commonProtocol (science)AnalystsChromatographyPoint (typography)ChemistryData CollectionOrganic ChemistryGeneral MedicineEvaluated validation parametersMethod developmentFully developedSOLID-PHASE EXTRACTIONESI-MS/MS METHODPHARMACEUTICAL DOSAGE FORMChromatography LiquidTHIN-LAYER-CHROMATOGRAPHY
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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