Search results for "EVAS"
showing 10 items of 482 documents
Hydrochemical mercury distribution and air-sea exchange over the submarine hydrothermal vents off-shore Panarea Island (Aeolian arc, Tyrrhenian Sea)
2017
Abstract There is a growing concern about the mercury (Hg) vented from submarine hydrothermal fluids to the marine surrounding and exchange of dissolved gaseous mercury (DGM) between the sea surface and the atmosphere. A geochemical survey of thermal waters collected from submarine vents at Panarea Island (Aeolian Islands, southern Italy) was carried out in 2015 (15–17th June and 17–18th November), in order to investigate the concentration of Hg species in hydrothermal fluids and the vertical distribution in the overlying water column close to the submarine exhalative area. Specific sampling methods were employed by Scuba divers at five submarine vents located along the main regional tecton…
Cuevas rituales ibéricas en el territorio de Kelin (ss. V-III a.C.).
2018
La Meseta de Requena-Utiel, en el interior de la provincia de Valencia, constituyó en época ibérica el territorio de la ciudad de Kelin. Entre otros aspectos, dicho territorio destacó por presentar una elevada concentración de cuevas con materiales ibéricos, de las cuales claramente cinco son resultado de prácticas rituales en su interior. Estas cuevas rituales fueron espacios estrechamente ligados al proceso de territorialización acaecido en la zona entre los siglos V y III a.C. En el presente artículo planteamos una revisión de sus características, ajuares y cronologías, integrándolas en todo momento en el paisaje y entorno inmediato. The Requena-Utiel plateau, in the interior of the Prov…
Arqueoentomología y arqueobotánica de los espacios de almacenamiento a largo plazo: el granero de Risco Pintado, Temisas (Gran Canaria)
2019
This contribution aims at understanding the storage techniques used in the past by means of studying the entomological and plant remains present in the pre-hispanic granary of Risco Pintado, dated between the IX and XV centuries cal AD.This type of granary groups together a large number of silos excavated in the volcanic tuff, situated on steep escarpments, difficult to access and easy to defend.The exceptional environmental conditions of these infrastructures have allowed the desiccated remains of the stored plant products and the pests associated with such storage to be preserved within the silos.The domestic species documented include cereals (barley and wheat), legumes (broad beans and …
Líquenes y hongos liquenícolas de la Serranía de Ronda (Málaga-Cádiz), sur de España
2017
As a result of a field trip organised by the Spanish Lichen Society in Serranía de Ronda, south Spain, a catalogue of 360 taxa is presented (336 lichens, 24 lichenicolous fungi). The list includes three new records for the Iberian Peninsula: Arthonia paretinaria, Micarea myriocarpa and Niesslia keissleri, 51new ones for the Autonomous Andalusian Community, and three and 81 new ones for the province of Cádiz and of Málaga, respectively. After these results, the total updated number of the province of Málaga rises to 556 lichens and lichenicolous fungi. The best represented lichen genus is Cladonia (18) with the most species, unlike Lecanora (15), Pertusaria (12), Physconia (12) and Collema (…
The thermal structure, subglacial topography and surface structures of the NE outlet of Eyjabakkajökull, east Iceland
2020
Abstract This study presents the detailed surveys of the NE outlet of Eyjabakkajokull glacier, East Iceland, from the combination of low-frequency ground penetrating radar (GPR), unmanned aerial vehicle (UAV) and GNSS measurements. Data analyses reveal the complex subglacial topography with a prominent, up to 45-m-deep longitudinal trough in the central part of the outlet that serves as the main trunk for the fast ice flow during the glacier surges. During the last decade (2010–2018), the studied part of the glacier has thinned by 4.37 m/yr on average and the ice margin has retreated ~750 m. We detect a boundary between scatter-free zone and zone of intense scattering near the ice margin an…
Using the r package spatstat to assess inhibitory effects of microregional hypoxia on the infiltration of cancers of the head and neck region by cyto…
2021
Simple Summary Progress in the field of in situ proteomics allows for the simultaneous detection of multiple biomarkers within one cancer tissue specimen. As a result, biological hypotheses previously only assessable ex vivo can now be studied in human cancer tissue. However, methods for objective analysis have so far been lacking behind. In this study, we established a free, objective, and entirely open-source-based method for the analysis of multiplexed immunofluorescence specimens. This will gain further importance with the availability of more advanced multiplexing methods in the future. Abstract (1) Background: The immune system has physiological antitumor activity, which is partially …
The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment
2021
Simple Summary Immunotherapy improved the therapeutic landscape for patients with advanced cancer diseases. However, many patients do not benefit from immunotherapy. The bidirectional crosstalk between myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) contributes to immune evasion, limiting the success of immunotherapy by checkpoint inhibitors. This review aims to outline the current knowledge of the role and the immunosuppressive properties of MDSC and Treg within the tumor microenvironment (TME). Furthermore, we will discuss the importance of the functional crosstalk between MDSC and Treg for immunosuppression, issuing particularly the role of cell adhesion molecules. …
Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins.
2017
Among nucleic acid–based delivery platforms, self-amplifying RNA (saRNA) vectors are of increasing interest for applications such as transient expression of recombinant proteins and vaccination. saRNA is safe and, due to its capability to amplify intracellularly, high protein levels can be produced from even minute amounts of transfected templates. However, it is an obstacle to full exploitation of this platform that saRNA induces a strong innate host immune response. In transfected cells, pattern recognition receptors sense double-stranded RNA intermediates and via activation of protein kinase R (PKR) and interferon signaling initiate host defense measures including a translational shutdow…
Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the “Test o…
2018
Human Cytomegalovirus (hCMV), which is the prototype member of the β-subfamily of the herpesvirus family, is a pathogen of high clinical relevance in recipients of hematopoietic cell transplantation (HCT). hCMV causes multiple-organ disease and interstitial pneumonia in particular upon infection during the immunocompromised period before hematopoietic reconstitution restores antiviral immunity. Clinical investigation of pathomechanisms and of strategies for an immune intervention aimed at restoring antiviral immunity earlier than by hematopoietic reconstitution are limited in patients to observational studies mainly because of ethical issues including the imperative medical indication …
Antibody trapping: A novel mechanism of parasite immune evasion by the trematode Echinostoma caproni
2017
Background Helminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in global health and the socioeconomic growth of developing countries. In this context, the study of helminth biology, with emphasis on host-parasite interactions, appears as a promising approach for developing new tools to prevent and control these infections. Methods/Principal findings The role that antibody responses have on helminth infections is still not well understood. To go in depth into this issue, work on the intestinal helminth Echinostoma caproni (Trematoda: Echinostomatidae) has been undertaken. Adult parasites were recovered from infected mice and cultured in vi…