Search results for "EXPA"
showing 10 items of 820 documents
Third virial coefficient for 4-arm and 6-arm star polymers
2008
We discuss the computation of the third virial coefficient in polymer systems, focusing on an additional contribution absent in the case of monoatomic fluids. We determine the interpenetration ratio and several quantities that involve the third virial coefficient for star polymers with 4 and 6 arms in the good-solvent regime, in the limit of a large degree of polymerization.
Changes in cell wall pectin and pectinase activity in apple and tomato fruits duringPenicillium expansum infection
2006
Cell wall pectin degradation in apple and tomato fruit during infection by Penicillium expansum was investigated. In infected apple fruit, a significant decrease in the average molecular mass was observed in pectins extracted with CDTA and also in pectins extracted with Na2CO3. In tomato fruits, depolymerisation was also observed in both pectic fractions during infection, the major change being in the pectins extracted with Na2CO3. This pectin depolymerisation associated with P. expansum infection can be attributed to the action of pectinases; in apple fruit, a significant increase in polygalacturonase and pectin methylesterase was observed in infected fruits, although in tomato fruit the o…
Aprendizaje de similitudes entre pares de objetos mediante clasificación supervisada
2017
El uso de medidas de similitud, distancias o métricas se encuentra en la base del funcionamiento de numerosas técnicas estándar de clasificación, resultando además, una tarea fundamental e importante en las áreas de estudio del Aprendizaje Automático (Machine Learning) y el Reconocimiento de Patrones (Pattern Recognition). Dado que el cálculo de la similitud entre dos objetos puede ser muy diferente en función del contexto, la construcción inteligente de estas medidas a partir de los datos disponibles, puede ayudar en la obtención de clasificadores más robustos y mejorar los resultados en la tarea específica que se propone resolver. En los últimos años, el aprendizaje de métricas (Metric Le…
Computational and theoretical studies on lattice thermal conductivity and thermal properties of silicon clathrates
2016
The lattice thermal conductivity is usually an intrinsic property in the study of thermoelectricity. In particular, relatively low lattice thermal conductivity is usually a desired feature when higher thermoelectric efficiency is pursued. The mechanisms which lower the lattice thermal conductivity are not known in sufficient detail and deeper understanding about the phenomena is needed and if such understanding is achieved it can be used to design more efficient thermoelectric materials. In this thesis, the lattice thermal conductivity and other thermal properties of several silicon clathrates, which are known to be promising candidates for the thermoelectric applications, are studied by theoreti…
Quo Vadis, Orthotrichum pulchellum? A Journey of Epiphytic Moss across the European Continent
2022
Orthotrichum pulchellum is a species of epiphytic moss in which a significant expansion from the oceanic part of Europe to the east of the continent has been observed in the recent two decades. The improvement in air quality in Central and Eastern Europe, but also climate change, probably plays a role in this. This study shows what direction of its spreading we can expect in the future. Ecological niche modeling (ENM) is a widespread method to find out species niches in environmental and geographical space, which allows us to highlight areas that have a higher probability of occurrences of the studied species, based on identifying similar environmental conditions to those already known. We …
Malignant colorectal obstruction. Palliative endoscopic treatment with self-expanding metallic stents
2005
The Authors report their experience in the palliative management of malignant colorectal obstruction. Between June 2000 and April 2003 sixteen patients (11 men and 5 women, age range 63-82) were found suffering from malignant colorectal obstruction. In these patients it was not possible to perform definitive surgical treatment because of the old age, advanced neoplastic disease and poor health condition, colostomy was the only therapeutic option. Endoscopic self-expanding stents placement was performed as a definitive palliative method to treat colorectal obstructions caused by advanced and unresectable tumours. This procedure was performed under endoscopic and fluoroscopic control and neit…
Genetic and Chemical Modifiers Of A CUG Toxicity Model in Drosophila
2007
Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced aspects of the DM1 pathology, most notably nuclear accumulation of CUG transcripts, muscle degeneration, splicing misregulation, and diminished Muscleblind function in vivo. Reduced Muscleblind activity was evident from the sensitivity of CUG-induced phenotypes to a decrease in muscleblind genetic dosage and rescue by MBNL1 expression, and furthe…
In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models
2011
6 pages, 5 figures. PMID:21730182[PubMed] PMCID: PMC3141925[Available on 2012/1/19]
Correction: Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotoni…
2018
ABSTRACT Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of MBNL sequestration in DM1 cardiac dysfunction is unclear. We overexpressed Muscleblind (Mbl), the Drosophila MBNL orthologue, in cardiomyocytes of DM1 model flies and observed a rescue of heart dysfunctions, which are characteristic of these model flies and resem…
Regional Policy Lessons from Finland
2005
The Finnish economy and society has long been dominated by primary production. Post-war economic development was rapid and welfare gaps between the much more developed economies and Finland narrowed and were even partly reversed. Rapid economic expansion together with structural change has had the effect of centralizing both economic activity and population. The trend has been towards the southern and central regions where the metropolitan area of Helsinki and most of the other larger towns and urban centres are located. Together with vigorous technological progress in agriculture and forestry the rapid urbanization and industrialization of the 1960s and 1970s the fastest in Europe altered …